Huihai Zhong

Correction to “Surgical Tumor-Derived Photothermal Nanovaccine for Personalized Cancer Therapy and Prevention”

Tan Li, Gengji Chen, Zecong Xiao, Bo Li et autres

Photo/chemo dynamic insights into the modulation of CuSe x via Fe dopant for enhanced synergistic therapy

Yan Mo, Xi Wu, Huihai Zhong, Beiping Miao et autres

Abstract Nanodynamic therapy integrating the merits of different dynamic therapy for maximizing the reactive oxygen species (ROS) generation serves as a highly efficient anti‐tumor strategy. Gaining dynamic insights into how nanomaterials modulate the anti‐tumor performance guides the rational design of nano‐drugs. Herein, …

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Rational Design of Nanozymes for Tumor Therapy─A Perspective

Huihai Zhong, Manman Zheng, Yujie Wang, Guohui Nie et autres

Nanozymes are nanomaterials with enzyme-like activities and have become a research hotspot in tumor therapy due to their exceptional properties. However, biological application of nanozymes remains a methodology and safety issue. More systematic and rational design of nanozymes is needed for better …

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Core–Satellite Nanoassembly Overcomes Spatial Heterogeneity of Dendric Cell Distribution in Pancreatic Tumors for Effective Chemoimmunotherapy

Gengjia Chen, Bo Li, Tan Li, Minzhao Lin et autres

Pancreatic cancer therapies such as chemotherapy and immunotherapy are hindered by the dense extracellular matrix known as physical barriers, leading to heterogeneity impeding the effective penetration of chemotherapeutic agents and activation of antitumor immune responses. To address this challenge, we developed a …

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Co-delivery of TRAIL DNA and salinomycin for cancer therapy via enhanced apoptosis and cancer stemness inhibition

Huihai Zhong, Yuefei Fang, Pengfei Zhao, Aihua Wu et autres

Nanocomposites co-delivering TRAIL plasmid and salinomycin potentiate TRAIL-induced apoptosis in carcinoma through coordinated modulation of the Wnt/β-catenin, STAT3, and c-Myc signaling axes coupled with ROS upregulation.

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γ-Glutamyl transpeptidase-activable nanoprobe crosses the blood-brain barrier for immuno-sonodynamic therapy of glioma

Bo Li, Gengjia Chen, Huihai Zhong, Tan Li et autres

Effective treatment against glioma remains challenging nowadays because the protective blood-brain barrier (BBB) impedes drug penetration into brain and the limited efficacy of conventional chemotherapy. While strong positively charged nanoparticles have good permeability through the BBB, they often come with the caveat …

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Violet phosphorus quantum dots regulate exciton dissociation and radial charge flow in crystalline g-C3N4 nanorods for boosting photocatalytic H2 evolution

Xi Wu, Qiaoling Yang, Bin Zhang, Huihai Zhong et autres

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Inside Back Cover: Twins‐like nanodrugs synchronously transport in blood and coalesce inside tumors for sensitive ultrasound imaging and triggerable penetrative drug delivery

Yujun Cai, Gengjia Chen, Minzhao Lin, Bo Li et autres

A novel strategy for nanoparticle size enlargement is developed by constructing a pair of similar nanodrugs, referred to as “twins-like nanodrugs (TLNs)”. The TLNs synchronously transport in blood, coalesce inside tumor and achieve particle aggregation for ultrasound-triggerable penetrative drug delivery (e476).

Ultrasound-irradiated bindable microbomb opens the blood-brain barrier to enhance glioma therapy

Bo Li, Huihai Zhong, Huiye Wei, Gengjia Chen et autres

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Twins‐like nanodrugs synchronously transport in blood and coalesce inside tumors for sensitive ultrasound imaging and triggerable penetrative drug delivery

Yujun Cai, Gengjia Chen, Minzhao Lin, Bo Li et autres

Abstract Nanodrugs capable of aggregating in the tumor microenvironment (TME) have demonstrated great efficiency in improving the therapeutic outcome. Among various approaches, the strategy utilizing electrostatic interaction as a driving force to achieve intratumor aggregation of nanodrugs has attracted great attention. However, …

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Violet Phosphorus Quantum Dots Regulate Exciton Dissociation and Radial Charge Flow in Crystalline G-C3n4 Nanorods for Boosting Photocatalytic H2 Evolution

Xi Wu, Qiaoling Yang, Bin Zhang, Huihai Zhong et autres

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Antioxidant activities of metal single-atom nanozymes in biomedicine

Qingdong Zeng, Huihai Zhong, Jiahao Liao, Qin Huo et autres

. Furthermore, due to the similar structure of antioxidant enzymes, a metal single-atom nanozyme often has multiple antioxidant activities, and this synergistic effect can more efficiently remove ROS related to oxidative stress. The versatility of single-atom nanozymes encompasses a broad spectrum of …

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