Accès ouvert
2026
article
OpenAlex
Daeeun Kim, Hannah G. Polikowsky, Heather M. Highland, Hung‐Hsin Chen et autres
BACKGROUND: While GWAS (genome-wide association studies) have identified over 1000 obesity-associated loci, their functional impact on gene expression remains unclear. Moreover, many studies have not fully captured the genetic architecture of obesity in high-risk populations or considered the complexity of adiposity beyond …
us, Afrique du Sud, tw, be
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Accès ouvert
2025
article
OpenAlex
Raymond Noordam, Wenyi Wang, Pavithra Nagarajan, Heming Wang et autres
BACKGROUND AND AIMS: Deviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels …
nl, us, gb, ee, au, fi, jp, de, no, fr, dk
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Tianzhen Liu, Qianqian Zhang, Yujie Wang, Changqing Liu et autres
Thiophenols, which are widely used in chemical and pharmaceutical industries, pose significant environmental and health hazards due to their high toxicity and volatility. Herein, we introduce CA-PhSH , a covalent-assembly fluorescent probe that leverages a Meldrum's-acid-based thiophenol-triggered nucleophilic substitution followed by rapid …
cn
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Accès ouvert
2025
article
OpenAlex
Xiayin Zhang, Shan Wang, Yan Wang, Fujun Jia et autres
Depression, which is increasingly prevalent among older adults, has traditionally been diagnosed through symptom-based questionnaires. However, emerging evidence suggests that retinal changes could serve as objective biomarkers for depression. In this study, we investigated the optic disc signature of depression by leveraging …
sg, cn, au, gb, hk
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Accès ouvert
2025
article
OpenAlex
Steven Buyske, Alyssa Scartozzi, Christopher R. Bauer, Gregorio V. Linchangco et autres
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limiting knowledge about its mechanisms and impacts. In genome-wide association study …
us
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Accès ouvert
2025
preprint
OpenAlex
Mengyu Zhang, Michael R. Brown, Amy R. Bentley, Thomas W. Winkler et autres
Abstract Cigarette smoking influences blood pressure (BP) levels. Studying and accounting for potential gene-smoking interactions can help discover novel loci and provide insights into biological pathways for smoking-associated BP regulation. We conducted a genome-wide association meta-analysis involving 1,188,241 individuals from 66 studies …
us, de, nl, kr, gb, Afrique du Sud, Gambie, Burkina Faso, es, ch, is, jp, at, fi, fr, it, sg, ca, cn, lk, au
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Accès ouvert
2025
article
OpenAlex
Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E. Justice, Geetha Chittoor et autres
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limiting knowledge about its mechanisms and impacts. In genome-wide association study …
us, nl, dk, ca, mx, no
(code pays fourni par la source)
2025
article
OpenAlex
Ningning Sun, Bi‐Yun Jia, Runyu Xu, Lifang Gao et autres
Parental birds exhibit diverse alternative reproductive strategies; however, the pathways by which these alternative strategies enhance the reproductive success of parents remain poorly understood. Here, we used generalised linear mixed models (GLMMs) and structural equation modelling (SEM) to analyse a long-term dataset …
cn, bd
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2025
conference-paper
OpenAlex
Huaizhi Qu, Yujie Wang, Ruichen Zhang, Samarjit Chakraborty et autres
Holographic displays are gaining increasing popularity, particularly as a holy grail solution to augmented and virtual reality (AR/VR) wearable displays. However, the generation of holograms is computationally intensive for AR/VR edge devices, which are expected to be compact and lightweight with low …
us
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2025
article
OpenAlex
Huihai Zhong, Manman Zheng, Yujie Wang, Guohui Nie et autres
Nanozymes are nanomaterials with enzyme-like activities and have become a research hotspot in tumor therapy due to their exceptional properties. However, biological application of nanozymes remains a methodology and safety issue. More systematic and rational design of nanozymes is needed for better …
cn
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Accès ouvert
2025
article
OpenAlex
Lu Zhang, Yujie Wang, Yuhan Ma, Guodong Zhao et autres
Background: Systemic contact dermatitis (SCD) occurs due to re-exposure to sensitizing agents via systemic routes, often triggered by drugs, metals, and food additives. Benzalkonium chloride, a cationic surfactant in different household products, can also induce allergic reactions. Case presentation: An 11-year-old girl …
cn
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2025
conference-paper
OpenAlex
Jin Li, Yujie Wang, Wenzheng Chen, Qiyu Dai et autres
3D object canonicalization is a fundamental task, essential for various downstream tasks. Existing methods rely on either cumbersome manual processes or priors learned from extensive, per- category training samples. Real- world datasets, however, often exhibit long- tail distributions, challenging existing learning- based …
cn, us
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