Tan Li

γ-Glutamyl transpeptidase-activable nanoprobe crosses the blood-brain barrier for immuno-sonodynamic therapy of glioma

Bo Li, Gengjia Chen, Huihai Zhong, Tan Li et autres

Effective treatment against glioma remains challenging nowadays because the protective blood-brain barrier (BBB) impedes drug penetration into brain and the limited efficacy of conventional chemotherapy. While strong positively charged nanoparticles have good permeability through the BBB, they often come with the caveat …

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Plasma metabolome mediates the causal relationship between immune cells and heart failure: a two-step bidirectional Mendelian randomization study

Tan Li, Yanwei Liu, Juncong Fu, Langlang Huang et autres

Background: Prior research has established a correlation between immune cell activity and heart failure (HF), but the causal nature of this relationship remains unclear. Furthermore, the potential influence of metabolite levels on this interaction has not been comprehensively explored. To address these …

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Nanodrug modified with engineered cell membrane targets CDKs to activate aPD-L1 immunotherapy against liver metastasis of immune-desert colon cancer

Dongbing Ding, Rongpu Liang, Tan Li, Tianyun Lan et autres

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The viscoelasticity, anisotropy and location-dependence of mechanical properties of rabbit iris investigated using uniaxial tensile tests

Tan Li, Zhicheng Liu, Haixia Zhang, Lin Li

PURPOSE: Abnormal iris mechanical properties have been considered to be an important cause of pupillary-block and angle-closure glaucoma. In this research, viscoelasticity, anisotropy and location-dependence of mechanical properties of rabbit iris were investigated using uniaxial tensile test. METHODS: Iris strips were taken …

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Probiotics ameliorate IgA nephropathy by improving gut dysbiosis and blunting NLRP3 signaling

Jiaxing Tan, Lingqiu Dong, Zheng Jiang, Tan Li et autres

BACKGROUND: Recently, a few studies have indicated a relationship between the gut microbiota and IgA nephropathy (IgAN). Whether the gut microbiota participates in the pathogenesis of IgAN and whether probiotics are effective in treating IgAN are still controversial. Therefore, this study aimed …

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Nanodrug enhances post-ablation immunotherapy of hepatocellular carcinoma via promoting dendritic cell maturation and antigen presentation

Zecong Xiao, Tan Li, Xinyao Zheng, Liteng Lin et autres

Thermal ablation (TA) as an effective method treating hepatocellular carcinoma (HCC) in clinics is facing great challenges of high recurrence and metastasis. Although immune-checkpoint blockade (ICB)-based immunotherapy has shown potential to inhibit recurrence and metastasis, the combination strategy of ICB and thermal …

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CDK12/13 inhibition induces immunogenic cell death and enhances anti-PD-1 anticancer activity in breast cancer

Yi Li, Hui Zhang, Qin Li, Pingjin Zou et autres

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[Effect of serum IgA/C3 and glomerular C3 staining on clinical prognosis in patients with IgA nephropathy].

Gaiqin Pei, Aiya Qin, S Q Wang, Tan Li et autres

Serum IgA/C3 ratio and glomerular C3 staining are predictors of renal clinical prognosis in patients with IgA nephropathy.

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Association of TIMP1 Levels and Liver Disease Progression Among HIV/HCV Co-infected, HIV Mono-, HCV Mono-infected, and Healthy Groups from the MASH Cohort (FS09-07-19)

Hyojung Kim, Tan Li, Jacqueline Hernández, Colby S. Teeman et autres

Antiretroviral therapy has increased life expectancy for HIV infected patients; however, this population is developing chronic illnesses associated with aging. Liver disease is a major cause of non-AIDS mortality, characterized by progressive fibrosis. Infection with HIV and with Hepatitis C Virus (HCV) …

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