Anjana Patel

Exploration of the role of SUMOylation machinery complex proteins, SENP1 and UBC9, in colorectal cancer progression

Mohammed Salih, Hussein A. S. Elrewey, Anjana Patel, Sonia G. Gaspar et autres

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A Novel Modulator of Resistance for Oxaliplatin-Based Therapy for Colorectal Cancer: The ESCRT Family Member VPS4A

Noha M. Abdelrazik, Anjana Patel, Andrew Conn, Chris W. Sutton et autres

Drug resistance is still one of the main challenges for the treatment of colorectal cancer (CRC). Whilst some resistance mechanisms are well known, from the static therapy success rate, clearly, still much is undiscovered. Intracellular transport mechanisms have attracted attention as having …

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A Novel Modulator of Resistance for Oxaliplatin-Based Therapy for Colorectal Cancer: The Escrt Family Member VPS4A

Noha M. Abdelrazik, Anjana Patel, Andrew Conn, Chris W. Sutton et autres

Drug resistance is still one of the main challenges for the treatment of colorectal cancer (CRC). Whilst some resistance mechanisms are well-known, from the static therapy success rate clearly still much is undiscovered. Intracellular transport mechanisms have come under attention as having …

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Abstract 2872: Methods of assessment of polysialyltransferase inhibitors for treatment of tumor cell dissemination

Xiaoxiao Guo, Jodie R. Malcolm, Anjana Patel, Marrwa M. Ali et autres

Abstract Polysialic acid (polySia) decorates the surface of NCAM (neuronal cell adhesion molecule) on neuroendocrine tumors, notably neuroblastoma and small cell lung cancer, and is strongly associated with poor prognosis and aggressive disease in patients in the clinic [1]. PolySia modulates tumor …

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An assay for quantitative analysis of polysialic acid expression in cancer cells

Xiaoxiao Guo, Sara M. Elkashef, Anjana Patel, Goreti Ribeiro Morais et autres

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KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

Euan S. Polson, Verena Kuchler, Christopher Abbosh, Edith Ross et autres

Pharmacological inhibition of uncontrolled cell growth with small-molecule inhibitors is a potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary brain cancer. We showed that the synthetic small-molecule KHS101 promoted tumor cell death in diverse GBM cell models, independent of …

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Characterising the surface activity of recombinant pulmonary surfactant proteins SP-B and SP-C together with synthetic analogues: Potential tear film supplements

V. F. Franklin, Aiman A. Gulamhussein, Anjana Patel, Alice J. Rothnie et autres

Progress towards recombinant synthesis of pulmonary surfactant proteins SP-B and SP-C

Anjana Patel, Roslyn M. Bill, Brian J. Tighe

Recombinant synthesis of pulmonary surfactant proteins SP-B and SP-C

Anjana Patel

SP-B and SP-C are two pulmonary surfactant proteins. They were isolated in the tear film in 2006 (Lukovic et al. 2006).The molecular mechanism governing lipid spreading in the tear film is not well understood and, along with their production in yeast (as …

The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

Euan S. Polson, Verena Kuchler, Christopher Abbosh, Edith Ross et autres

Abstract Pharmacological inhibition of uncontrolled cell growth with small molecule inhibitors is a potential strategy against glioblastoma multiforme (GBM), the most malignant primary brain cancer. Phenotypic profiling of the neurogenic small molecule KHS101 revealed the chemical induction of lethal cellular degradation in …

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RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells

Harry O. King, Tim Brend, Helen L. Payne, Alexander Wright et autres

Patients with glioblastoma die from local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought to be due to efficient DNA double-strand break (DSB) repair in stem-like cells able to survive DNA damage and repopulate the tumor. We used clinical …

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CBIO-33INVESTIGATING GLIOMA CELL PHENOTYPES WITH SMALL MOLECULES

Euan S. Polson, Verena Kuchler, Christopher Abbosh, Anjana Patel et autres

High-grade brain tumours are characterized by inter- and intratumour heterogeneity and remain incurable despite current multi-modality treatment. The cellular aggressiveness within brain tumours includes tumour cell invasion of healthy brain tissue, resistance to conventional therapy, and greatly enhanced growth potential. This has …

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