Chien‐Hsiu Li

c-Myc transactivates CFL1 to induce senescence-like phenotype and potentiate the bystander effects for the migration and proliferation in lung cancer cells

Yen-Ting Chou, Jyh-Der Leu, Wan-Yu Yang, Chien‐Hsiu Li et autres

Abstract Oncogene-induced senescence (OIS) is regarded a tumor suppressive mechanism in normal cells. Accumulated evidences, however, demonstrate that OIS would play a role in cancer promotion through the secretion of senescence associated secretory phenotypes (SASP). The underlying mechanisms remain to be addressed. …

tw (code pays fourni par la source)

Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis

Su-Wei Hu, Chia-Chang Wu, Shaowei Dong, Kai-Yi Tzou et autres

The inability to effectively identify the formation of advanced-stage tumors poses a challenge in precisely determining when to intervene in prostate cancer (PCa). Despite the use of PSA as a screening factor, it still falls short in significantly improving the diagnosis and …

tw (code pays fourni par la source)

The prognostic and neuroendocrine implications of SLC25A29-mediated biomass signature in prostate cancer

Chia-Chang Wu, Su-Wei Hu, Shaowei Dong, Kai-Yi Tzou et autres

tw (code pays fourni par la source)

Magnetically Guided Theranostics: Novel Nanotubular Magnetic Resonance Imaging Contrast System Using Halloysite Nanotubes Embedded with Iron–Platinum Nanoparticles for Hepatocellular Carcinoma Treatment

Ming‐Hsien Chan, Chi‐Yu Lee, Chien‐Hsiu Li, Yu‐Chan Chang et autres

Magnetically Guided Theranostics In article number 2300526, Ming-Hsien Chan and co-workers report that a novel halloysite ceramic nanotube can uniformly arrange FePt nanoparticles as nanocomposites to optimize the magnetic properties in a 3D tubular space that syndicates with chemotherapeutic drugs to achieve …

tw (code pays fourni par la source)

WNT1-inducible signaling pathway protein 1 activation through C-X-C motif chemokine ligand 5/C-X-C chemokine receptor type 2/leukemia inhibitory factor/leukemia inhibitory factor receptor signaling promotes immunosuppression and neuroendocrine differentiation in prostate cancer

Ke Hung Tsui, Chien‐Liang Liu, Hsiu-Lien Yeh, Mingkun Liu et autres

The interaction between prostate cancer (PCa) cells and prostate stromal cells fosters an immunosuppressive tumor microenvironment (TME) that promotes tumor growth and immune evasion. However, the specific signaling pathways involved remain unclear. We identified a key mechanism involving the CXCL5/CXCR2 and LIF/LIFR …

tw, lb (code pays fourni par la source)

Binding of interleukin-1 receptor antagonist to cholinergic receptor muscarinic 4 promotes immunosuppression and neuroendocrine differentiation in prostate cancer

Yen‐Nien Liu, Mingkun Liu, Yu-Ching Wen, Chien‐Hsiu Li et autres

The tumor microenvironment (TME) of prostate cancer (PCa) is characterized by high levels of immunosuppressive molecules, including cytokines and chemokines. This creates a hostile immune landscape that impedes effective immune responses. The interleukin-1 (IL-1) receptor antagonist (IL1RN), a key anti-inflammatory molecule, plays …

tw, us (code pays fourni par la source)

Magnetically Guided Theranostics: Novel Nanotubular Magnetic Resonance Imaging Contrast System Using Halloysite Nanotubes Embedded with Iron–Platinum Nanoparticles for Hepatocellular Carcinoma Treatment

Ming‐Hsien Chan, Chi‐Yu Lee, Chien‐Hsiu Li, Yu‐Chan Chang et autres

Halloysite nanotubes (HNTs) have a layered structure of clay silicate minerals and a tubular shape, which is suitable for the uniform loading of small substrates and drug molecules. The inner diameter of HNTs with an acidic solvent is selectively etched to increase …

tw (code pays fourni par la source)

PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression

Yu‐Chan Chang, Ming‐Hsien Chan, Chien‐Hsiu Li, Chi‐Long Chen et autres

Glioblastoma (GBM) is a type of brain cancer categorized as a high-grade glioma. GBM is characterized by limited treatment options, low patient survival rates, and abnormal serotonin metabolism. Previous studies have investigated the tumor suppressor function of aldolase C (ALDOC), a glycolytic …

tw (code pays fourni par la source)

RAB31 drives extracellular vesicle fusion and cancer‐associated fibroblast formation leading to oxaliplatin resistance in colorectal cancer

Yu‐Chan Chang, Yi‐Fang Yang, Chien‐Hsiu Li, Ming‐Hsien Chan et autres

Abstract Epithelial‐mesenchymal transition (EMT) is associated with tumorigenesis and drug resistance. The Rab superfamily of small G‐proteins plays a role in regulating cell cytoskeleton and vesicle transport. However, it is not yet clear how the Rab family contributes to cancer progression by …

tw (code pays fourni par la source)

Correction: CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer

Yu‐Ching Wen, Van Thi Ngoc Tram, Weihao Chen, Chien‐Hsiu Li et autres

5 Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

tw, us (code pays fourni par la source)

Comprehensive Neurotoxicity of Lead Halide Perovskite Nanocrystals in Nematode Caenorhabditis elegans

Loan Thi Ngo, Wen‐Tse Huang, Ming‐Hsien Chan, Ting‐Yi Su et autres

To date, all-inorganic lead halide perovskite quantum dots have emerged as promising materials for photonic, optoelectronic devices, and biological applications, especially in solar cells, raising numerous concerns about their biosafety. Most of the studies related to the toxicity of perovskite quantum dots …

tw (code pays fourni par la source)

CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer

Yu‐Ching Wen, Van Thi Ngoc Tram, Weihao Chen, Chien‐Hsiu Li et autres

Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling. Inhibiting effects of AR may activate neuroendocrine differentiation and lineage plasticity pathways, thereby promoting the development of neuroendocrine prostate cancer (NEPC). Understanding the regulatory mechanisms of AR has important …

tw, us (code pays fourni par la source)