Yen‐Nien Liu

Characterization of Diverse Functions of NRF1 Nuclear Localization Sequence

Gleb Shamrin, Gagan Kajla, Sachin Kumar, Yen‐Nien Liu et autres

Most of the transcription factors require a nuclear localization signal (NLS) to translocate to the nucleus via the nuclear import machinery. Initially, classical monopartite NLS with an arginine-lysine basic box was discovered, later less common bipartite NLS with two basic boxes separated …

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Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer

Wei-Yu Chen, Kuan‐Hua Huang, Gagan Kajla, Yu-Ching Wen et autres

Neuroendocrine prostate cancer (NEPC) is a lethal, treatment-resistant subtype that arises through lineage transdifferentiation from castration-resistant prostate cancer (CRPC) under selective pressure from androgen deprivation therapy. Although EGFR tyrosine kinase inhibitors (TKIs) represent a rational therapeutic strategy, their clinical efficacy remains limited, …

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TREND: A generalizable synthetic enhancer discovery platform for targeted immunotherapy

Yingbo Jia, Chu-Yen Chen, Bo Zhu, Zhigui Wu et autres

Synthetic enhancers with high specificity are crucial for therapeutic gene control. However, experimental screens and machine learning-guided design typically require context-specific datasets, limiting generalizability. Because transcription factor (TF) activity reflects cellular state, TF-responsive enhancer libraries offer a universal starting point. Here, we …

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A calcium-sensing MCTP1/FYN/MEF2C circuit drives therapy-induced neuroendocrine prostate cancer

Phan Vu Thuy Dung, Wei‐Yu Chen, Mingkun Liu, Shauh-Der Yeh et autres

Neuroendocrine prostate cancer (NEPC) represents a highly aggressive, treatment‑refractory phenotype that frequently emerges after androgen‑deprivation therapy (ADT). Although perturbed calcium signaling has been implicated in prostate cancer bone metastasis, the specific molecular mechanisms governing NEPC progression remain incompletely characterized. Here, we delineate …

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Repurposing piroxicam enhances the antineoplastic effects of docetaxel and enzalutamide in prostate cancer cells using 2D and 3D in vitro culture models

Amani Yehya, Fatima Ghamlouche, Sana Hachem, Zahraa Salhab et autres

Introduction: Drug repurposing is gaining consideration in cancer due to the challenges of poor outcomes and resistance associated with the current conventional modalities. Non-steroidal anti-inflammatory drugs (NSAIDs), widely used for treating inflammation, are being explored for their potential efficacy in cancer treatment, …

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Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis

Su-Wei Hu, Chia-Chang Wu, Shaowei Dong, Kai-Yi Tzou et autres

The inability to effectively identify the formation of advanced-stage tumors poses a challenge in precisely determining when to intervene in prostate cancer (PCa). Despite the use of PSA as a screening factor, it still falls short in significantly improving the diagnosis and …

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WNT1-inducible signaling pathway protein 1 activation through C-X-C motif chemokine ligand 5/C-X-C chemokine receptor type 2/leukemia inhibitory factor/leukemia inhibitory factor receptor signaling promotes immunosuppression and neuroendocrine differentiation in prostate cancer

Ke Hung Tsui, Chien‐Liang Liu, Hsiu-Lien Yeh, Mingkun Liu et autres

The interaction between prostate cancer (PCa) cells and prostate stromal cells fosters an immunosuppressive tumor microenvironment (TME) that promotes tumor growth and immune evasion. However, the specific signaling pathways involved remain unclear. We identified a key mechanism involving the CXCL5/CXCR2 and LIF/LIFR …

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Binding of interleukin-1 receptor antagonist to cholinergic receptor muscarinic 4 promotes immunosuppression and neuroendocrine differentiation in prostate cancer

Yen‐Nien Liu, Mingkun Liu, Yu-Ching Wen, Chien‐Hsiu Li et autres

The tumor microenvironment (TME) of prostate cancer (PCa) is characterized by high levels of immunosuppressive molecules, including cytokines and chemokines. This creates a hostile immune landscape that impedes effective immune responses. The interleukin-1 (IL-1) receptor antagonist (IL1RN), a key anti-inflammatory molecule, plays …

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MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT

Yen‐Nien Liu, Wei‐Yu Chen, Hsiu‐Lien Yeh, Wei-Hao Chen et autres

Neuroendocrine prostate cancer (PCa) (NEPC), an aggressive subtype that is associated with poor prognosis, may arise after androgen deprivation therapy (ADT). We investigated the molecular mechanisms by which ADT induces neuroendocrine differentiation in advanced PCa. We found that transmembrane protein 1 (MCTP1), …

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PD42-10 IMMUNOSUPPRESSIVE ROLE OF BDNF IN THERAPY-INDUCED NEUROENDOCRINE PROSTATE CANCER

Yu‐Tsan Lin, Yen‐Nien Liu, Weiyu Chen, Yu‐Ching Wen

You have accessJournal of UrologyProstate Cancer: Markers II (PD42)1 May 2024PD42-10 IMMUNOSUPPRESSIVE ROLE OF BDNF IN THERAPY-INDUCED NEUROENDOCRINE PROSTATE CANCER Yu-Tsan Lin, Yen-Nien Liu, Wei-Yu Chen, and Yu-Ching Wen Yu-Tsan LinYu-Tsan Lin , Yen-Nien LiuYen-Nien Liu , Wei-Yu ChenWei-Yu Chen , and …

Immunosuppressive role of BDNF in therapy‐induced neuroendocrine prostate cancer

Yen‐Nien Liu, Wei‐Yu Chen, Ming‐Kun Liu, Hsiu‐Lien Yeh et autres

Prostate stromal cells play a crucial role in the promotion of tumor growth and immune evasion in the tumor microenvironment (TME) through intricate molecular alterations in their interaction with prostate cancer (PCa) cells. While the impact of these cells on establishing an …

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Correction: CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer

Yu‐Ching Wen, Van Thi Ngoc Tram, Weihao Chen, Chien‐Hsiu Li et autres

5 Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

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