Zhengying Su

Corrigendum: Honokiol ameliorates post-myocardial infarction heart failure through Ucp3-mediated reactive oxygen species inhibition

Jianyu Liu, Minghai Tang, Tao Li, Zhengying Su et autres

[This corrects the article DOI: 10.3389/fphar.2022.811682.].

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Correction to “Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity”

Linyu Yang, Wanhua Zhang, Qiang Qiu, Zhengying Su et autres

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity"Linyu YangLinyu YangMore by Linyu Yang, Wanhua ZhangWanhua ZhangMore by Wanhua Zhang, Qiang QiuQiang QiuMore by Qiang Qiu, Zhengying …

Honokiol Ameliorates Post-Myocardial Infarction Heart Failure Through Ucp3-Mediated Reactive Oxygen Species Inhibition

Jianyu Liu, Minghai Tang, Tao Li, Zhengying Su et autres

Post-myocardial infarction heart failure (post-MI HF) is one of the leading global causes of death, and current prevention and treatment methods still cannot avoid the increasing incidence. Honokiol (HK) has previously been reported to improve myocardial ischemia/reperfusion injury and reverse myocardial hypertrophy …

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Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity

Linyu Yang, Wanhua Zhang, Qiang Qiu, Zhengying Su et autres

Hydroxamic acid group is one of the characteristic pharmacophores of histone deacetylase (HDAC) inhibitors. But here, we discovered a series of hydroxamic acid-based microtubule destabilizing agents (MDAs), which were derived from shortening the length of the linker in HDAC6 inhibitor SKLB-23bb. Interestingly, …

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[Constraction of triple negative breast cancer cell model containing EGFR promoter and luciferase reporter gene].

Dandan Liang, Chunmiao Wang, Junying Li, Liangshu Qin et autres

Objective To establish a triple negative breast cancer cell line stably expressing human epidermal growth factor receptor (EGFR) promoter and luciferase (Luc) reporter gene and to preliminarily verify its application. Methods Using genetic recombination technology, the lentiviral vector carrying Luc reporter and …

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Design, synthesis and anti‐inflammatory study of novel N‐heterocyclic substituted Aloe‐emodin derivatives

Xiang Qiu, Heying Pei, Hengfan Ni, Zhengying Su et autres

Abstract A novel series of Aloe‐emodin derivatives containing N‐heterocyclic moieties was designed and synthesized. The structure‐activity relationship studies (SARs) indicated that the replacement of hydroxyethyl and benzhydryl piperazine groups could improve efficacy. Compounds 12r and 14a–14c exhibited a higher inhibitory effect on …

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Rac1: A potential radiosensitization target of human nasopharyngeal carcinoma CNE2 cells

Chunmiao Wang, Zhaoquan Li, Zhiyu Pan, Zhengying Su et autres

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β-Elemene-loaded polymeric micelles intensify anti-carcinoma efficacy and alleviate side effects

Qiaoqiao Hu, Lan Bai, Zejiang Zhu, Zhengying Su et autres

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Synthesis and Screening of Novel Anthraquinone−Quinazoline Multitarget Hybrids as Promising Anticancer Candidates

Dandan Liang, Zhengying Su, Wei Tian, Junying Li et autres

Aim: The EGF receptor (EGFR) is overexpressed in multiple epithelial-derived cancers and is considered to be a vital target closely associated with cancer therapy. In this study, a series of novel anthraquinone−quinazoline hybrids targeting several vital sites for cancer therapy were designed …

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Anti-Tumor Study of H6, a 4-Substituted Coumarins Derivative, Loaded Biodegradable Self-Assembly Nano-Micelles In Vitro and In Vivo

Zejiang Zhu, Zhengying Su, Jianhong Yang, Huili Liu et autres

In our previous study, we identified a class of 4-substituted coumarins as a powerful microtubule inhibitors binding to the colchicine site of β-tubulin. H6 showed potent anti-proliferative ability with IC50 values from 7 to 47 nM, and remarkable ability to reduce tumor …

Novel Anthraquinone Compounds Induce Cancer Cell Death through Paraptosis

Wei Tian, Junying Li, Zhengying Su, Lan Fu et autres

Novel anthraquinone compounds that induce ER stress and paraptosis-like cell death were designed and synthesized. Compound 4a is the first organic micromolecule to kill tumor cells by only paraptosis, and its mechanism of action has been further explored. Paraptosis does not appear …

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A novel Rhein derivative: Activation of Rac1/NADPH pathway enhances sensitivity of nasopharyngeal carcinoma cells to radiotherapy

Zhengying Su, Zhaoquan Li, Chunmiao Wang, Wei Tian et autres

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