Zhiyu Pan

Differential expression and prognostic role of ACACA, ACLY, and FASN in schistosomiasis-associated versus hepatitis B virus-related liver cancer

Xiaoyi Wang, Yi-hui Sun, Qiong-Le Wu, Manman Liang et autres

OBJECTIVE: To investigate the clinicopathological differences between schistosomiasis-related liver cancer (Sj-LC) and hepatitis B virus-related liver cancer (HBV-LC), as well as the expression and prognostic significance of key lipid metabolism enzymes (ACACA, ACLY, FASN). METHODS: A retrospective analysis was performed on 309 …

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Multiple tail vein injections of adipose-derived mesenchymal stem cells ameliorate allergic rhinitis in mice: superior efficacy of prolonged regimens

Yutong Xie, Jiacheng Zhang, Wenhan Yang, Zhiyu Pan et autres

Background: Adipose derived mesenchymal stem cells (ADSCs) are a subset of mesenchymal stem cells (MSCs), showing broad anti allergic effects in type 2 inflammation. Their systemic efficacy in allergic rhinitis (AR) is not well defined. In this study, we tested whether prolonged …

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Precise staging of severe fever with thrombocytopenia syndrome: Integrating the extent of organ damage for prognostic and therapeutic applications

Hao Yao, Jing Sun, Qiongle Wu, Yingchun Sun et autres

OBJECTIVES: This study aimed to develop an accurate staging system for SFTS (Severe Fever with Thrombocytopenia Syndrome) based on the dynamic assessment of organ damage. This staging is intended to improve prognostication and guide treatment strategies. METHODS: Clinical data and laboratory parameters …

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Comparison of the safety and efficacy between endovenous laser ablation and radiofrequency ablation for great saphenous vein incompetence

Xianhao Su, Hongjian Ding, Zhiyu Pan, Huaqing Li et autres

Aims This multicenter retrospective study sought to compare the efficacy and safety of endovenous laser ablation (EVLA) versus radiofrequency ablation (RFA) for treating great saphenous vein (GSV) incompetence. Methods We performed propensity score matching (PSM) between 864 EVLA and 1009 RFA cases. …

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Establishment and application of a grading diagnostic model for early detection of severe fever with thrombocytopenia syndrome

Hao Yao, Yingchun Sun, Zhiyu Pan, Jing Sun et autres

OBJECTIVE: There is an urgent need to develop a reliable and efficient method for the early identification and diagnosis of severe fever with thrombocytopenia syndrome (SFTS). METHODS: This retrospective multicentre study analysed data from 363 patients with SFTS, which included general information …

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Administration Strategy-Dependent Mechanisms and Effects of Human Adipose Tissue Stem Cell Extracellular Vesicles in Mouse Allergic Rhinitis Treatment

Wenhan Yang, Zhiyu Pan, Jiacheng Zhang, Lian Y. Wang et autres

We previously found that intravenous injection of extracellular vesicles (EVs) from human adipose tissue-derived stem cells (hADSC) could ameliorate allergic rhinitis (AR) in mice through immunomodulatory effects. In clinical trials, nasal delivery has been an attractive treatment for AR. We sought to …

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Extracellular vesicles from adipose stem cells ameliorate allergic rhinitis in mice by immunomodulatory

Wenhan Yang, Zhiyu Pan, Jiacheng Zhang, Lian Y. Wang et autres

Background: Human adipose tissue-derived stem cells (hADSCs) exert potent immunosuppressive effects in the allogeneic transplantation treatment. In mouse model of allergic rhinitis (AR), ADSCs partially ameliorated AR. However, no study has evaluated the potential therapeutic effects of hADSC-derived extracellular vesicles (hADSC-EVs) on …

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Integration of pharmacodynamics, network pharmacology and metabolomics to elucidate effect and mechanism of Artemisia capillaris Thunb. in the treatment of jaundice

Qing Yang, Xubo Wu, Zhiyu Pan, Ruifang Guan et autres

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MicroRNA-342-3p loaded by human umbilical cord mesenchymal stem cells-derived exosomes attenuates deep vein thrombosis by downregulating EDNRA

Zhiyu Pan, Qian Chen, Hongjian Ding, Huaqing Li

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CircWHSC1 Promotes Breast Cancer Progression by Regulating the FASN/AMPK/mTOR Axis Through Sponging miR-195-5p

Qian Chen, Zhen Yang, Hongjian Ding, Huaqing Li et autres

Numerous studies reveal that circular RNAs (circRNAs) affect cancer progression. CircWHSC1 is a novel circRNA that accelerates ovarian cancer progression. Nevertheless, the function of circWHSC1 in regulating breast cancer (BC) is elusive. Here, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was carried out …

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Intra-Tumoral Expression of SLC7A11 Is Associated with Immune Microenvironment, Drug Resistance, and Prognosis in Cancers: A Pan-Cancer Analysis

Jiajun He, Hongjian Ding, Huaqing Li, Zhiyu Pan et autres

While many anti-cancer modalities have shown potent efficacy in clinical practices, cancer prevention, timely detection, and effective treatment are still challenging. As a newly recognized iron-dependent cell death mechanism characterized by excessive generation of lipid peroxidation, ferroptosis is regarded as a potent …

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MicroRNA-342-3p lOaded by Human Umbilical Cord Mesenchymal Stem Cells-derived Exosomes Attenuates Deep Vein Thrombosis by Downregulating EDNRA Running Title: Exosome Delivery of miR-342-3p in DVT

Zhiyu Pan, Qian Chen, Hongjian Ding, Huaqing Li

Abstract Objective: Exosomes (exos) exert biological functions to maintain the dynamic balance of cells and tissues by transferring biological cargo to recipient cells. Thus, this study explored human umbilical cord mesenchymal stem cells (hucMSCs)-derived exo transfer of microRNA (miR)-342-3p in deep vein …

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