Qiang Qiu

Cholesterol sulfate replenishment rejuvenates aged hematopoietic stem cell phenomes

Yunyu Feng, Ning Li, Nan Wang, Wei He et autres

The aging of hematopoietic stem cells (HSCs) impairs their regenerative and self-renewal capacities, contributing to immune dysfunction and hematologic diseases, yet safe and effective rejuvenation strategies remain elusive. Methods: experiments further explored the role of the nuclear receptor RORA. Results: Supplementation with …

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Rora Regulates Hematopoietic Stem Cell Phenotypes and Progression of Chronic Myelogenous Leukemia

Ning Li, Yunyu Feng, Nan Wang, Wei He et autres

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E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

Haochen Wang, Junbo Peng, Hui Li, Jing Guo et autres

E3 ubiquitin ligases are pivotal regulators within the ubiquitin-proteasome system, conferring specificity to protein ubiquitination and subsequent degradation, thereby maintaining cellular homeostasis. Their structural diversity allows for the precise control of vital processes, including the cell cycle, immune responses, and signal transduction, …

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P-selectin overexpression impairs hematopoietic stem cell homeostasis via inflammatory receptor-mediated proliferation and differentiation

Wei He, Huandi Qiu, Yunyu Feng, Qiang Qiu et autres

Hematopoietic stem cells (HSC) sustain lifelong blood and immune system homeostasis. This study identifies P-selectin as a pivotal regulator of HSC function under aging and inflammatory stress. We observed pronounced Selp upregulation in aged HSC and inflammatory contexts, which drives excessive proliferation …

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Exploring the potential toxic mechanisms of bisphenol F exposure in acute myeloid leukemia: Insights from network toxicology, molecular docking and experimental validation

Yali Tao, Biao Ran, Jinjin Wang, Qian Hu et autres

Bisphenol F (BPF), a major alternative to bisphenol A (BPA), is now widely used worldwide, posing significant risks to human health and the environment. Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy with a poor prognosis. This investigation aims to …

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Preclinical and first-in-human of purinostat mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed/refractory multiple myeloma and lymphoma

Linyu Yang, Qiang Qiu, Jie Wang, Yi Wen et autres

Abstract Simultaneously targeting key pathogenic drivers and remodeling of the tumor microenvironment represents a critical therapeutic strategy for relapsed or refractory (r/r) multiple myeloma (MM) and lymphoma. Purinostat mesylate (PM), a highly selective HDAC I/II binhibitor, exhibits excellent antitumor activity in MM …

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A blockade of leukotriene-mediated Alox5 function provides a new strategy for the treatment of JAK2V617F-induced polycythemia vera

Yi Shan, Ngoc Ho DeSouza, Noah Littman, Qiang Qiu et autres

Polycythemia vera (PV) is a hematopoietic stem cell disorder characterized by JAK2V617F, a mutation that gives rise to erythrocytosis. Our previous studies have shown that arachidonate 5-lipoxygenase (Alox5) is a critical driver in PV and the inhibition of the Alox5 pathway attenuates …

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Transcriptome profiling uncovers differentially expressed genes linked to nutritional quality in vegetable soybean

Xueyang Wang, Chunlei Zhang, Rongqiang Yuan, Xiulin Liu et autres

Vegetative soybean (maodou or edamame) serves as a nutrient-rich food source with significant potential for mitigating global nutritional deficiencies. This study undertook a thorough examination of the nutritional profiles and transcriptomic landscapes of six soybean cultivars, including three common cultivars (Heinong551, Heinong562, …

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Discovery of a Potent, Orally Active, and Long-Lasting P2X7 Receptor Antagonist as a Preclinical Candidate for Delaying the Progression of Chronic Kidney Disease

Ruijia Zhang, Kaiyue Su, Letian Yang, Huaichuan Duan et autres

Chronic kidney disease (CKD) is a condition characterized by functional deterioration with sustained inflammation and progressive fibrosis of the kidneys affecting over 800 million people worldwide. The P2X7 receptor (P2X7R) plays a key role in CKD progression. Our previous P2X7R antagonists demonstrated …

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Toxicokinetics, in vivo metabolic profiling and tissue distribution of chlorfenapyr in mice

Shunjie Zhang, Xin Wang, Xia Yang, Ziyang Ma et autres

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Exploring the Health Benefits of Boletus aereus Polysaccharides: Extraction, Structural Characterization, and Antiproliferative Properties against Non-Hodgkin’s Lymphomas (NHLs)

Haidi Wang, Linyu Yang, Qiang Qiu, Qianru Rao et autres

Boletus aereus Fr. ex Bull. stands out as a delectable edible mushroom with high nutritional and medicinal values, featuring polysaccharides as its primary nutrient composition. In our continuous exploration of its beneficial substances, a novel polysaccharide (BAPN-1) with a molecular weight of …

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Atp8a1 deletion increases the proliferative activity of hematopoietic stem cells by impairing PTEN function

Li Zheng, Cong Pan, Wanli Tian, Cailing Liang et autres

PURPOSE: The eukaryotic cell plasma membrane contains several asymmetrically distributed phospholipids, which is maintained by the P4-ATPase flippase complex. Herein, we demonstrated the biological effects and mechanisms of asymmetrical loss in hematopoietic stem cells (HSCs). METHODS: An Atp8a1 knockout mouse model was …

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