Anna Brandt

Inflammation and limited adaptive immunity predict worse outcomes on immunotherapy in head and neck cancer

Lisa Paschold, Christoph Schultheiß, Paul Schmidt-Barbo, Konrad Klinghammer et autres

Most patients with relapsed or metastatic head and neck squamous cell carcinoma (rmHNSCC) do not experience durable responses to PD-1 immune checkpoint inhibitors. PD-L1 tissue expression is the most commonly assessed response marker, but an insufficient predictor of treatment outcome. To identify …

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Expansions of circulating plasmablasts producing commensal-reactive IgA antibodies are predictors for chronic GVHD

Katharina Habenicht, Jana Wanzek, Anna Bootz, Simon T. Schafer et autres

ABSTRACT: Chronic graft-versus-host disease (cGVHD) is characterized by dysregulation of the adaptive immune system, including an aberrant B-cell homeostasis after allogeneic hematopoietic stem cell transplantation (allo-SCT). It is uncertain, however, whether this B-cell dysregulation is a result of manifest cGVHD or develops …

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UV1 vaccination in pembrolizumab-treated patients with recurrent or metastatic head and neck cancer: A randomized multicenter phase 2 trial

Anna Brandt, Konrad Klinghammer, Christoph Schultheiß, Lisa Paschold et autres

BACKGROUND: Human telomerase reverse transcriptase is highly expressed in head and neck squamous cell carcinoma (HNSCC). The FOCUS study examines the role of the telomerase-directed vaccine UV1 in combination with pembrolizumab in patients with recurrent or metastatic (R/M) HNSCC. METHODS: HNSCC. A …

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Inflammatory signature and restriction of adaptive immunity are associated with unfavorable outcomes on immune checkpoint blockade in patients with advanced head and neck squamous cell carcinoma

Lisa Paschold, Christoph Schultheiß, Paul Schmidt-Barbo, Konrad Klinghammer et autres

ABSTRACT Background In most patients with relapsed or metastatic head and neck squamous cell carcinoma (rmHNSCC), immunotherapy with PD-1 targeting antibodies does not yield durable responses. PD-L1 tissue expression - the most commonly assessed marker for checkpoint inhibiting antibodies - is an …

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UV1 cancer vaccine in pembrolizumab-treated patients with recurrent or metastatic PD-L1 positive head and neck squamous cell carcinoma: results from the randomized phase 2 FOCUS trial

Anna Brandt, Konrad Klinghammer, Christoph Schultheiß, Lisa Paschold et autres

Abstract Background Human telomerase reverse transcriptase (hTERT) is highly expressed (75-100%) in head and neck squamous cell carcinoma (HNSCC). The FOCUS study examines the role of the hTERT-directed vaccine UV1 in combination with pembrolizumab in patients with recurrent or metastatic (R/M) HNSCC. …

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Effect of Adipose Biopsy Technique on Inflammatory Markers in Adipose Tissue

Anna Brandt, Colleen Lynch, Ethan Robbins, Toby L. Chambers et autres

Objectives: The purpose of this study was to compare adipose tissue (AT) biomarkers obtained from the Bergström and Mercedes biopsy techniques in healthy, recreationally active adults. Hypotheses: There would be no difference in expression of inflammatory and adipokine genes of interest between …

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Tolerability and efficacy of the cancer vaccine UV1 in patients with recurrent or metastatic PD-L1 positive head and neck squamous cell carcinoma planned for first-line treatment with pembrolizumab – the randomized phase 2 FOCUS trial

Anna Brandt, Christoph Schultheiß, Konrad Klinghammer, Philippe Schafhausen et autres

Background: Globally, head and neck squamous cell carcinoma (HNSCC) is the seventh most common malignancy. Despite aggressive multimodal treatment approaches, recurrent and/or metastatic (R/M) disease develops in >50% of patients. In this setting, pembrolizumab was approved for patients with PD-L1 expression. However, …

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R-00266-2023 Supplemental Tables 1-4 12.22.23.pdf

Colleen E. Lynch, Anna Brandt, Caroline Vincenty, Ethan Robbins et autres

R-00266-2023 Supplemental Tables 1-4 12.22.23

Proliferative activity of normal tissues and malignant tumors during infestation of the organism by a biotic ecopathogen

A. G. Rybka, Igor Sholomov, Anna Brandt

The article shows the role of metabolites of metacercariae and opisthorchiae in the induction of proliferative activity of somatic cells of the hepatobiliary system and other organs. The importance of cellular and tissue bioregulators in increasing the level of proliferative activity of …

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P352: PROPHYLACTIC AND PREEMPTIVE USE OF DLI COMPARE FAVOURABLY TO THEIR THERAPEUTIC USE IN ADULT ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) – RESULTS OF A MULTICENTRE RETROSPECTIVE STUDY

M.M.C. Haupt, Nadja Jäkel, Maria Wachsmuth, Michael Stadler et autres

Topic: 2. Acute lymphoblastic leukemia - Clinical Background: Relapsed ALL after allogeneic stem cell transplantation (SCT) is associated with a poor prognosis. The therapeutic use of donor lymphocyte infusion (DLI) upon clinical relapse is established, but its efficacy is limited. Preemptive (based …

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Effect of adipose biopsy technique on adipocyte size and integrity

Anna Brandt, Colleen Lynch, Gerard Boyd, Caroline Vincenty et autres

Objectives: The purpose of this study was to compare adipocyte size and integrity in adipose tissue between Mercedes and Bergström biopsy techniques in healthy, recreationally active adults. Hypothesis: There would be no difference in adipocyte size between the Mercedes and Bergström techniques. …

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Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma

Anna Brandt, Benjamin Thiele, Christoph Schultheiß, Eveline Daetwyler et autres

Tumors shed cell-free DNA (cfDNA) into the plasma. "Liquid biopsies" are a diagnostic test to analyze cfDNA in order to detect minimal residual cancer, profile the genomic tumor landscape, and monitor cancers non-invasively over time. This technique may be useful in patients …

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