Nicole M. Ashpole

Early Life Exposure to Δ 9 -Tetrahydrocannabinol Causes Persistent Growth, Behavior, and Bioenergetic Outcomes in Zebrafish

Zacharias Pandelides, Cammi Thornton, Jason J. Paris, Nicole M. Ashpole et autres

Introduction: Although classified in the United States as Schedule I drugs, medical and recreational cannabis and Δ 9 -tetrahydrocannabinol (THC) are becoming increasingly consumed by pregnant women. Determining the potential adverse effects following exposure during early development is essential for risk communication. …

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Sex differences in the capacity of minor phytocannabinoids to attenuate nociceptive insults in HIV-1 Tat-expressing mice

Alaa N. Qrareya, Emaya M. Moss, Fakhri Mahdi, Mohammed Salahuddin et autres

Objecives: Approximately 80 % of people living with HIV (PLWH) develop chronic pain and preclinical studies support the involvement of the HIV-1 regulatory protein, trans-activator of transcription (Tat). Phytocannabinoids may attenuate pain in PLWH; however, these data are controversial, and the biological …

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Insulin-like growth factor-1 and cognitive health: Exploring cellular, preclinical, and clinical dimensions

Cellas A. Hayes, Miguel A. De Leon, Michelle C. Odden, Nicole M. Ashpole

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Visualization and Quantification of Intraepidermal Nerve Fibers (IENFs) in Mouse Epidermis via PGP9.5 Labeling and Confocal Microscopy v1

M Wilford De Leon, Anna Weimer, Nicole M. Ashpole

Intraepidermal nerve fibers (IENFs) are thin, unmyelinated nerve fibers that extend from the dermis into the epidermis. Consisting mostly of C-fibers and some Aδ-fibers, these fibers are involved in sensory transduction processes, including pain (nociception), thermosensation, and itch. Due to these roles, …

Cannabinoid Receptor Type II Ligands from Sandalwood Oil and Synthetic α-Santalol Derivatives

Pradeep Paudel, Pankaj Pandey, Jason J. Paris, Nicole M. Ashpole et autres

Bioassay-guided fractionation of the essential oil of Santalum album led to the identification of α-santalol ( 1 ) and β-santalol ( 2 ) as new chemotypes of cannabinoid receptor type II (CB 2 ) ligands with K i values of 10.49 and …

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Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage

Cellas A. Hayes, Nyah I. Morgan, Kamryn C. Thomas, M. Jake Pushie et autres

Ischemic stroke is a leading cause of death and disability, as therapeutic options for mitigating the long-term deficits precipitated by the event remain limited. Acute administration of the neuroendocrine modulator insulin-like growth factor-1 (IGF-1) attenuates ischemic stroke damage in preclinical models, and …

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Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice

Alaa N. Qrareya, Fakhri Mahdi, Marc J. Kaufman, Nicole M. Ashpole et autres

In the U.S. about half of the HIV-infected individuals are aged 50 and older. In men living with HIV, secondary hypogonadism is common and occurs earlier than in seronegative men, and its prevalence increases with age. While the mechanisms(s) are unknown, the …

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Safety and Pharmacokinetics of Intranasally Administered Heparin

Hannah M. Harris, Katherine L. Boyet, Hao Liu, Rohini Dwivedi et autres

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6,5‐Fused Ring, C2‐Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects**

Nicholas S. Akins, Nisha Kant Mishra, Hannah M. Harris, Narendar Reddy Dudhipala et autres

Current common analgesics are mediated through the mu or kappa opioid receptor agonism. Unfortunately, selective mu or kappa receptor agonists often cause harmful side effects. However, ligands exhibiting dual agonism to the opioid receptors, such as to mu and kappa, or to …

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Identification of an Orally Bioavailable, Brain-Penetrant Compound with Selectivity for the Cannabinoid Type 2 Receptor

Meirambek Ospanov, Suresh Ponnayyan Sulochana, Jason J. Paris, John M. Rimoldi et autres

Modulation of the endocannabinoid system (ECS) is of great interest for its therapeutic relevance in several pathophysiological processes. The CB2 subtype is largely localized to immune effectors, including microglia within the central nervous system, where it promotes anti-inflammation. Recently, a rational drug …

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Insulin-Like Growth Factor-1 Differentially Modulates Glutamate-Induced Toxicity and Stress in Cells of the Neurogliovascular Unit

Cellas A. Hayes, Brandon G. Ashmore, Akshaya Vijayasankar, Jessica P. S. Marshall et autres

The age-related reduction in circulating levels of insulin-like growth factor-1 (IGF-1) is associated with increased risk of stroke and neurodegenerative diseases in advanced age. Numerous reports highlight behavioral and physiological deficits in blood-brain barrier function and neurovascular communication when IGF-1 levels are …

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Adulthood Deficiency of the Insulin-like Growth Factor-1 Receptor in Hippocampal Neurons Impairs Cell Structure and Spatial Learning and Memory in Male and Not Female Mice

Cellas A. Hayes, Erik L. Hodges, Jessica P. S. Marshall, Sreemathi Logan et autres

ABSTRACT Reductions in insulin-like growth factor-1 (IGF-1) are associated with cognitive impairment and increased risk of neurodegenerative disease in advanced age. In mouse models, reduced IGF-1 early-in-life leads to memory impairments and synaptic dysfunction; however, these models are limited by systemic reductions …

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