Wei Zhu

NSUN6-mediated 5-methylcytosine modification of USP2-AS1 drives Wnt/β-catenin signaling in brain arteriovenous malformations

Ganglei Li, Mingjian Liu, Hongfei Zhang, Sichen Li et autres

Brain arteriovenous malformations (bAVMs) are high-risk vascular lesions prone to intracranial hemorrhage, with unclear upstream regulatory mechanisms. We integrated 5-methylcytosine (m 5 C) RNA methylation sequencing and transcriptomics in ruptured and unruptured bAVMs to identify differentially methylated non-coding RNAs. Functional validation was …

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Multi-omics analysis reveals NSUN2-mediated m5C methylation of DOCK9 regulating vascular stability in brain arteriovenous malformations

Ganglei Li, Hongfei Zhang, Biyun Wang, Junrui Chen et autres

RNA 5-methylcytosine (m5C) methylation is a key post-transcriptional modification, yet its role in vascular stability remains unclear. Through integrative m5C-RNA immunoprecipitation and transcriptomic, proteomic, and single-cell analyses of ruptured and unruptured human brain arteriovenous malformations (bAVMs), we find DOCK9 to be an …

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Network Disconnection Syndrome in Unruptured Brain Arteriovenous Malformations: A Multimodal Connectome Study

Xuchen Dong, Haojing Duan, Yingtao Liu, Zhiyuan Fan et autres

BACKGROUND: Cognitive impairment is a critical yet poorly understood complication of brain arteriovenous malformations (bAVM). While traditionally attributed to hemodynamic "steal" or focal tissue destruction, it remains unclear whether cognitive variability correlates with gross structural pathology or broader network disruption. METHODS: We …

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Examining the spatial configuration of street junctions across cities: a fractal approach on intra-urban clusters

Wei Zhu, Ding Ma, Biao He, Xiaomin Lu et autres

Urban streets form the backbone of cities, and variations in street-junction spatial configuration provide valuable insights into urban form and function, both of which exhibit fractal and scaling characteristics in their structural and statistical properties. However, these patterns emerge from the interaction …

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The value of modified time-of-flight magnetic resonance venography in evaluating anatomical variations of the internal iliac vein

Ziyu Zuo, Xiaoyu Zhang, Wei Zhu, Yong Xu et autres

Objective: To investigate the feasibility of using modified time-of-flight magnetic resonance venography (mTOF-MRV) to evaluate the anatomical variations of the internal iliac vein (IIV). Methods: This retrospective study included 158 patients suspected of iliac vein compression syndrome (IVCS) who underwent pelvic mTOF-MRV …

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Association between bone marrow adipose tissue, abdominal adipose tissue distribution, and volumetric bone mineral density in the Chinese adult population: a retrospective cohort study

Wei Zhu, Wenmin Guan, Bo-Xin Chen, Yue Lu et autres

Background Increasing studies have suggested that bone closely interacts with bone marrow adipose tissue (BMAT) and abdominal adipose tissue. However, this relationship remains debated. This study aimed to explore the association among BMAT, abdominal adipose tissue, and lumbar volumetric bone mineral density …

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Letter Re: The art of diagnosing rare skin tumors: Can DL-CNNs enhance dermatologists’ diagnostic accuracy

Lijun Ye, Wei Zhu, Yan Liang, Yingjian Ye et autres

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Erdafitinib in Patients with High- and Intermediate-risk Non–muscle-invasive Bladder Cancer: Final Analysis of THOR-2 Study

Siamak Daneshmand, Renata Zaucha, James W.F. Catto, Ben Tran et autres

BACKGROUND AND OBJECTIVE: High-risk (HR) or intermediate-risk (IR) non-muscle-invasive bladder cancer (NMIBC) carries a high probability of recurrence and/or progression. We present the final analysis results of erdafitinib in HR- or IR-NMIBC with fibroblast growth factor receptor 3/2 alterations (FGFR3/2alt) from the …

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Revisiting urban scaling through street-based hotspots across 360 Chinese cities

Ding Ma, Lili Deng, Renzhong Guo, Zhengdong Huang et autres

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Tubular epithelial cell-derived extracellular vesicles carrying serum amyloid A1 exacerbate sepsis-associated acute kidney injury by promoting NETs formation

Yang Jiao, Mei Liu, Xin Xie, Mengying Pi et autres

Introduction: Sepsis-associated acute kidney injury (SA-AKI) is a highly lethal condition with a rapid onset, and effective treatments are lacking because the molecular pathogenesis remains unclear. Tubular epithelial cells (TECs) have increasingly been recognized as driving forces in the progression of kidney …

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Integrating network pharmacology and transcriptomics to reveal the anti-hepatocellular carcinoma effects of Nigella B via activation of the P38MAPK pathway

Xiubin Jia, Zhao Wang, Runze Zhang, Wei Zhu et autres

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A multiregional multimodal machine learning model for predicting outcome of surgery for symptomatic hemorrhagic brainstem cavernous malformations

Xuchen Dong, Haohuai Gui, Kai Quan, Zongze Li et autres

OBJECTIVE: Given that resection of brainstem cavernous malformations (BSCMs) ends hemorrhaging but carries a high risk of neurological deficits, it is necessary to develop and validate a model predicting surgical outcomes. This study aimed to construct a BSCM surgery outcome prediction model …

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