Yang Jiao

Bioinspired Spatiotemporal‐Responsive Nanoparticles Synergistically Regulate Mitochondrial Repair and Inhibit Fibrosis in Acute Myocardial Infarction Treatment

Yinuo Yang, Jian Shen, Keyi Huang, Haimang Wang et autres

Cardiovascular diseases, particularly acute myocardial infarction (AMI), have posed a significant global health burden due to the high morbidity and mortality rates. Current treatment methods are compromised by a narrow therapeutic window, risk of ischemia-reperfusion injury, rapid systemic drug clearance, and inadequate …

cn (code pays fourni par la source)

High‐Concentrated Reactive Oxygen Species from Chiral Thyroxine for Piezocatalytic Antitumor Therapy

Zhilin Yang, Nan Yuan, Yang Jiao, Najun Li et autres

Abstract Piezocatalytic therapy based on piezoelectric nanomaterials has emerged as an effective strategy to induce the generation of reactive oxygen species (ROS) for tumor inhibition. But the biocompatibility and toxicity risks during treatment and metabolic processes of the inorganic piezoelectric materials are …

cn (code pays fourni par la source)

MicroRNA biomarkers in cerebrospinal fluid and plasma predicting cognitive decline in Alzheimer's disease

Yang Jiao, Yanfei Ding, Ningdi Luo, Mengyue Niu et autres

BackgroundMicroRNAs (miRNAs) have emerged as key regulators in Alzheimer's disease (AD), yet their function as biomarkers remains uncertain due to inconsistent findings in blood and cerebrospinal fluid (CSF).ObjectiveWe aimed to identify miRNAs that track disease progression, providing valuable insights into AD pathophysiology.MethodsThis …

cn (code pays fourni par la source)

Tubular epithelial cell-derived extracellular vesicles carrying serum amyloid A1 exacerbate sepsis-associated acute kidney injury by promoting NETs formation

Yang Jiao, Mei Liu, Xin Xie, Mengying Pi et autres

Introduction: Sepsis-associated acute kidney injury (SA-AKI) is a highly lethal condition with a rapid onset, and effective treatments are lacking because the molecular pathogenesis remains unclear. Tubular epithelial cells (TECs) have increasingly been recognized as driving forces in the progression of kidney …

cn (code pays fourni par la source)

Effect of gate oxide thickness on gate latent damage induced by heavy ion in SiC power MOSFETs

Shiwei Zhao, Yuzhu Liu, Xiaoyu Yan, Peipei Hu et autres

cn (code pays fourni par la source)

A comparative study of human norovirus and human sapovirus contamination in oysters (Crassostrea gigas) tissues from physical markets and e-commerce platforms in Guangzhou, China

Junshan Gao, Yijing Li, Yang Jiao, Weicheng Cai et autres

cn (code pays fourni par la source)

MicroRNA biomarkers in cerebrospinal fluid and plasma are associated with reduced cognitive decline in Alzheimer's Disease

Yang Jiao, Yanfei Ding, Mengyue Niu, Ningdi Luo et autres

Abstract Background Despite the promising prospects of using microRNAs in Alzheimer's disease (AD) research, several challenges remain unresolved. Method Our study analyzed the changes in microRNA expression levels in cerebrospinal fluid (CSF) and plasma samples and their association with concurrent cognitive decline …

cn (code pays fourni par la source)

Annexin 1 Reduces Dermatitis-Induced Itch and Cholestatic Itch through Inhibiting Neuroinflammation and Iron Overload in the Spinal Dorsal Horn of Mice

Li Tang, Lingyue Hu, Chao Qin, Yuanjie Li et autres

The unclear pathogenesis of chronic itch originating from several systemic disorders poses challenges to clinical intervention. Recent studies recapitulate the spinal neurocircuits associated with neuroinflammation and synaptic plasticity responsible for pruriceptive sensations. The resolution of nociception and inflammation by Annexin 1 (ANXA1) …

cn (code pays fourni par la source)

Euchromatin histone-lysine N-methyltransferase 2 regulates the expression of potassium-sodium-activated channel subfamily T member 1 in primary sensory neurons and contributes to remifentanil-induced pain sensitivity

Qiang Zhang, Ran Ding, Yuanjie Li, Dan Qiao et autres

Intraoperative remifentanil administration has been linked to increased postoperative pain sensitivity. Recent studies have identified the involvement of euchromatic histone-lysine N-methyltransferase 2 (Ehmt2/G9a) in neuropathic pain associated with the transcriptional silencing of many potassium ion channel genes. This study investigates whether G9a …

cn (code pays fourni par la source)

Transcriptome-wide analysis of the differences between MCF7 cells cultured in DMEM or αMEM

Yang Jiao, Hongbo Zhao, Linlin Lu, Xiangyu Zhao et autres

MCF7 cells have been used as an experimental model for breast cancer for decades. Typically, a culture medium is designed to supply cells with the nutrients essential for their continuous proliferation. Each medium has a specific nutritional composition. Therefore, cells cultured in …

cn (code pays fourni par la source)

An integrated analysis of bulk and single-cell sequencing data reveals that EMP1+/COL3A1+ fibroblasts contribute to the bone metastasis process in breast, prostate, and renal cancers

Haoyuan Du, Hua Wang, Yuwei Luo, Yang Jiao et autres

Introduction: Bone metastasis (BoM) occurs when cancer cells spread from their primary sites to a bone. Currently, the mechanism underlying this metastasis process remains unclear. Methods: In this project, through an integrated analysis of bulk-sequencing and single-cell RNA transcriptomic data, we explored …

cn (code pays fourni par la source)

Ubiquitin-specific peptidase 47 (USP47) regulates cutaneous oxidative injury through nicotinamide nucleotide transhydrogenase (NNT)

Xiaoqian Li, Kun Qian, Yuehua Zhang, Yining Zhang et autres

cn (code pays fourni par la source)