Jörg Hennenlotter

Disease stage-dependent expression of ADC-related biomarkers in urothelial carcinoma

Steffen Rausch, Alicia Bombyk, Lena Müller, Jörg Hennenlotter et autres

Background: Biomarker-driven therapies have expanded treatment options for advanced urothelial carcinoma (UC), making reliable assessment of therapeutic targets increasingly important for patient selection and treatment sequencing. The aim of this study was to evaluate the expression of clinically relevant biomarkers [Trop2, HER2/neu, …

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Optimize human sperm cryopreservation: influence of vial sealing methods and automated freezing protocols on preserved sperm quality

Pauline Haase, Steffen Rausch, Moritz Maas, Simon Walz et autres

Background: Cryopreservation of human sperm is an essential procedure for fertility preservation in oncological patients. Despite its clinical relevance apart from the recommendations of the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen, there is yet …

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Nectin-4 Expression in Muscle-Invasive Bladder Cancer Is Associated with Growth-Related and Inflammatory Signaling Pathways

Sebastian Jersinovic, Marko Vuković, Jörg Hennenlotter, Thomas Lütfrenk et autres

Nectin-4 has emerged as a clinically relevant target in muscle-invasive bladder cancer (MIBC), primarily because of its role in antibody–drug conjugate-based therapies. However, the broader biological context of Nectin-4 expression and its association with tumor-promoting signaling pathways in MIBC remain insufficiently characterized. …

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Significant differences in CD276 (B7H3) expression between female and male bladder cancer tissue samples: An exploratory study

Niklas Harland, Lea E. Reitnauer, Bastian Amend, Veronika Bahlinger et autres

CD276 is an immune checkpoint antigen. Elevated CD276 expression is a hallmark of many malignancies and is frequently associated with poor prognosis. Elevated CD276 levels have been reported in bladder cancer (BC)[1]; however, CD276 sex disparities have not yet been investigated in …

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Topographical and stage-related expression of nectin-4 in prostate cancer

Radion Garaz, Jörg Hennenlotter, Veronika Bahlinger, Tilman Todenhöfer et autres

Introduction: Nectin-4 is a cell-adhesion molecule overexpressed in several malignancies and is a promising therapeutic target. Its expression profile and clinical relevance in prostate cancer (PCa) remain insufficiently defined. Material and methods: This retrospective study at a single tertiary referral center included …

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Drug targeting of the monocarboxylate transporter MCT4 is a novel treatment strategy for metastatic ccRCC

Lena-Sophie Menig-Benzig, Viktoria Stühler, Pascale Mazzola, H.C. Heinrich et autres

Clear cell renal cell carcinoma (ccRCC) is characterized by a metabolic shift towards enhanced aerobic glycolysis and increased lactate production. The survival rate for metastatic RCC is still poor. We evaluated the lactate monocarboxylate transporter 4 (MCT4), encoded by SLC16A3, as drug …

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Metastasis-Specific CpG Island DNA Hypermethylation of the Long Non-Coding RNA Gene 00404 in Renal Cell Carcinoma

Pouriya Faraj Tabrizi, Inga Schimansky, Inga Peters, Jörg Hennenlotter et autres

Background/Objectives: Alterations in long non-protein-coding RNAs (lncRNAs) are known to influence cellular proliferation, apoptosis, and metastasis in human cancers, including renal cell carcinoma (RCC). Methods: Using pyrosequencing, we analyzed DNA methylation (DNAm) at 23 loci within the LINC00404 CpG island across 28 …

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Results of the Prospective Randomized UroFollow Trial Comparing Marker-guided Versus Cystoscopy-based Surveillance in Patients with Low/Intermediate-risk Bladder Cancer

Bernd J. Schmitz-Dräger, E. Bismarck, Florian Roghmann, Nicolas von Landenberg et autres

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Impact of interdisciplinary tumor boards (ITB) and personalized treatment on survival outcomes in metastatic castration-resistant prostate cancer

Laura Lawaczeck, Jörg Hennenlotter, Joël Hammes, Valentina Spingler et autres

PURPOSE: Interdisciplinary tumor boards (ITB) are essential in optimizing treatment recommendations for metastatic castration-resistant prostate cancer (mCRPC) by incorporating oncology guidelines, clinical trials, and patient-specific factors to ensure individualized care. This study examines clinical parameters that influence ITB recommendations, evaluates their adherence …

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Metastasis-Specific CpG Island DNA Hypermethylation of the Long Non-Coding RNA Gene 00404 in Renal Cell Carcinoma

Jörg Hennenlotter

Impact of sociodemographic and socioeconomic factors on functional and health-related quality of life outcomes 24 months after radical prostatectomy

Steffen Rausch, Moritz Maas, Katharina Funk, Viktoria Stühler et autres

Potential impacts to human health from climate change: A comparative life-cycle assessment of single-use versus reusable devices flexible ureteroscopes

Marlene Thöne, Jan Lask, Jörg Hennenlotter, Matthias Saar et autres

Abstract Climate change poses a significant global health challenge, with medical procedures contributing substantially to CO2 emissions. Urology, as part of the broader healthcare sector, has begun integrating Planetary Health concepts to address this issue. While earlier studies have focused on Life …

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