Accès ouvert
2026
article
OpenAlex
W Lu, Maddison Waters, Josie Larby, Sapha Shibeeb et autres
Cigarette smoking is a major driver of airway and systemic inflammation and contributes to the development and progression of chronic obstructive pulmonary disease (COPD). This study compared peripheral blood inflammatory markers and immune cell profiles in smokers with and without COPD and …
au, in
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Wenying Lu, Affan Mahmood Shahzad, Josie Larby, Maddison Waters et autres
Introduction/Aim: Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing and irreversible fibrotic disease. Obesity has been reported to contribute to inflammation and fibrotic changes in chronic lung disease, though its role in IPF remains under investigation. In this study, we present novel …
au, ws, ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Surajit Dey, Wenying Lu, Prabuddha S. Pathinayake, Maddison Waters et autres
Introduction: Asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO) is a term used to describe a patient with coexisting clinical features of asthma and COPD. We have previously reported that epithelial to mesenchymal transition (EMT) is active in the lungs of …
au
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Accès ouvert
2024
article
OpenAlex
Wenying Lu, Affan Mahmood Shahzad, Josie Larby, Maddison Waters et autres
To the editor:Idiopathic pulmonary fibrosis (IPF) is a chronically progressive and irreversible fibrosing disease with an unknown cause. The development of IPF is initiated with repetitive injury t...
au, ws, ca
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Wenying Lu, Josie Larby, Greg Haug, Sukhwinder Singh Sohal
Introduction: Smoking is a major trigger of inflammation and a key contributor to COPD pathogenesis. This study evaluated the blood inflammatory cell populations in smokers with and without COPD, providing insights into COPD management. Methodology: Blood samples from 80 consented patients with …
au
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Surajit Dey, Wenying Lu, Greg Haug, Collin Chia et autres
BACKGROUND: Although asthma and chronic obstructive pulmonary disease (COPD) are two distinct chronic airway inflammatory diseases, they often co-exist in a patient and the condition is referred to as asthma-COPD overlap (ACO). Lack of evidence regarding the inflammatory cells in ACO airways …
au
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Wenying Lu, Archana Vijay Gaikwad, Collin Chia, Josie Larby et autres
Introduction: Our previous studies have shown that aberrant arterial remodelling occurs in IPF patients, and EndMT contributes to such remodelling changes. Aim: We aim to evaluate EndMT drivers in size-based pulmonary arteries from IPF patients compared to healthy controls (HC). Methods: Lung …
au, gb, ca
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Wenying Lu, Collin Chia, Josie Larby, Greg Haug et autres
Introduction: Our previous studies have shown active EMT in smokers and COPD patients, which is central to lung cancer development in these patients. Aim: We aim to evaluate EMT changes in extensive patient groups who were diagnosed with NSCLC (adenocarcinoma and squamous …
au, gb, ca
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Wenying Lu, Surajit Dey, Archana Vijay Gaikwad, Prem Bhattarai et autres
Background: Lack of evidence on the inflammatory cell populations in ACO airways has led to their poor prognosis and treatment. Aim: To enumerate inflammatory cell changes in the airway wall of ACO and compare them with asthma (AS), COPD current smokers (CS) …
au, gb
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Samuel James Brake, Wenying Lu, Collin Chia, Greg Haug et autres
Background COPD is a common disease characterized by respiratory airflow obstruction. TGF-β1 and SMAD pathway is believed to play a role in COPD pathogenesis by driving epithelial mesenchymal transition (EMT). Methods We investigated TGF-β1 signalling and pSmad2/3 and Smad7 activity in resected …
au, ca
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Archana Vijay Gaikwad, Wenying Lu, Surajit Dey, Prem Bhattarai et autres
Background: We have previously reported arterial remodelling in patients with idiopathic pulmonary fibrosis (IPF) and suggested that endothelial-to-mesenchymal transition (EndMT) might be central to these changes. This study aims to provide evidence for active EndMT in IPF patients. Methods: Lung resections from …
au, ca
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Prem Bhattarai, Wenying Lu, Archana Vijay Gaikwad, Surajit Dey et autres
Introduction: Pulmonary vascular remodelling in chronic obstructive pulmonary disease (COPD) has detrimental consequences for lung physiology. The aim of our study was to provide a comprehensive size-based morphometric quantification of pulmonary arterial remodelling in smokers and in patients with small airway disease …
au, ca
(code pays fourni par la source)