Profiling inflammatory cell populations in endobronchial biopsies from patients with asthma COPD overlap (ACO)
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Le résumé fourni par la source
Background: Lack of evidence on the inflammatory cell populations in ACO airways has led to their poor prognosis and treatment. Aim: To enumerate inflammatory cell changes in the airway wall of ACO and compare them with asthma (AS), COPD current smokers (CS) and ex-smokers (ES), normal lung function smokers (NLFS) and non-smoker controls (HC). Methods: A total of 144 immunohistochemically stained endobronchial biopsy tissues from pathological groups and HC were evaluated for macrophages (MPs), neutrophils (NLs), eosinophils, mast cells (MCs), CD4+, and CD8+ T cells in the epithelium (EPI), reticular basement membrane (RBM), and lamina propria (LP) up to 120 µM deep using Image-Pro Plus 7 software. Results: We found that the number of MPs in ACO tissue was much higher in the EPI and RBM than in HC (p<0.001 for both), COPD-ES (p<0.001 for both), and -CS (p<0.05 and <0.0001, respectively). The ACO LP MPs were substantially higher than COPD-CS (p<0.05). MCs in ACO were significantly lower than NLFS (p<0.05) in the EPI; lower than COPD (p<0.05) and NLFS (p<0.001) in RBM; and lower than HC (p<0.05) in LP. We noted reduced eosinophils in the ACO LP than HC (p<0.05) and the lowest NLs in ACO and asthma. Furthermore, CD8+ cells increased in the ACO RBM compared to HC (p<0.05), COPD-ES (p<0.05), and NLFS (p<0.01); however, they were similar in the epithelium and LP across groups. CD4+ cells remained lower across all regions and groups. Conclusion: These results show that the inflammatory cellular profile of ACO airway tissue was different from that of asthma and COPD, with MPs being the predominant cell type.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Profiling inflammatory cell populations in endobronchial biopsies from patients with asthma COPD overlap (ACO)
- Date Crossref
- 09/09/2023
- Éditeur
- European Respiratory Society
- Type
- proceedings-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Tasmania pays non établi dans la noticeUniversité ou école supérieure
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Launceston General Hospital Department of Respiratory Medicine pays non établi dans la noticeÉtablissement de santé
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North West Regional Hospital Lung Function Unit pays non établi dans la noticeÉtablissement de santé
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Hunter Medical Research Institute pays non établi dans la noticeStructure de recherche
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John Hunter Hospital pays non établi dans la noticeÉtablissement de santé
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School of Health Sciences Department of Laboratory Medicine pays non établi dans la noticeUniversité ou école supérieure
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North-West Hospital Department of Respiratory Medicine pays non établi dans la noticeÉtablissement de santé
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University of Newcastle Hunter Medical Research Institute pays non établi dans la noticeUniversité ou école supérieure
University of Tasmania, Department of Respiratory Medicine — Launceston General Hospital et Lung Function Unit — North West Regional Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.