Aleyda Benitez‐Amaro

Correction for: ApoB100 remodeling and stiffened cholesteryl ester core raise LDL aggregation in familial hypercholesterolemia patients [Journal of Lipid Research 66/1 (2025) 100703]

Maria Teresa La Chica Lhoëst, Andrea Soledad Duarte Martínez, Eduardo Garcı́a, Jany Dandurand et autres

An incomplete correlogram was originally supplied for Figure 7. A revised version of the figure has been provided, and no changes to the text were necessary. The revision does not affect the findings and conclusions presented in the article.

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Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells

Eduardo Garcı́a, Lene Claudi, Maria Teresa La Chica Lhoëst, Анна Полищук et autres

BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular tone, endothelial function, and inflammation. Our …

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LRP1 immunotherapy enhances cardiomyocyte respiration by restricting cholesteryl ester accumulation in mitochondria

Aleyda Benitez‐Amaro, Elisa Rubio-García, Maria Teresa La Chica Lhoëst, A.R. Polishchuk et autres

) of LDL receptor-related protein 1 (anti-P3 Abs) inhibit the interaction between ApoB100 in cholesteryl ester (CE)-enriched lipoproteins and the CR9 domain in LDL receptor-related protein 1, preventing intracellular CE accumulation induced by a high-fat high-cholesterol (HFHC) diet in cardiomyocytes. This study …

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ApoB100 remodeling and stiffened cholesteryl ester core raise LDL aggregation in familial hypercholesterolemia patients

Maria Teresa La Chica Lhoëst, A. Martínez, Elisa Rubio-García, Jany Dandurand et autres

Patients with familial hypercholesterolemia (FH) exhibit a significant residual cardiovascular risk. A new cardiovascular risk factor is the susceptibility of individual LDL particles to aggregation. This study examined LDL aggregation and its relationship with LDL lipid composition and biophysical properties in patients …

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Targeting LDL aggregation decreases atherosclerotic lipid burden in a humanized mouse model of familial hypercholesterolemia: Crucial role of ApoB100 conformational stabilization

Aleyda Benitez‐Amaro, Elisa Rubio-García, Maria Teresa La Chica Lhoëst, A. Martínez et autres

Background and aims Low-density lipoprotein (LDL) aggregation is nowadays considered a therapeutic target in atherosclerosis. DP3, the retro-enantio version of the sequence Gly 1127 -Cys 1140 of LRP1, efficiently inhibits LDL aggregation and foam cell in vitro formation. Here, we investigate whether …

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Increased sLRP1 and decreased atrial natriuretic peptide plasma levels in newly diagnosed T2DM patients are normalized after optimization of glycemic control

Eduardo Garcı́a, Pedro Gil, Inka Miñambres, Aleyda Benitez‐Amaro et autres

Background: Low-density lipoprotein receptor-related protein 1 (LRP1) negatively modulates circulating atrial natriuretic peptide (ANP) levels. Both molecules are involved in the regulation of cardiometabolism. Objectives: To evaluate soluble LRP1 (sLRP1) and ANP levels in people with newly diagnosed type 2 diabetes mellitus …

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Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia

V. Samouillan, Eduardo Garcı́a, Aleyda Benitez‐Amaro, Maria Teresa La Chica Lhoëst et autres

High Resolution Image Download MS PowerPoint Slide The accumulation of lipids in cardiomyocytes contributes to cardiac dysfunction. The specific blockage of cardiomyocyte cholesteryl ester (CE) loading by antibodies (Abs) against the P3 sequence (Gly 1127 –Cys 1140 ) of the LRP1 receptor …

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Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by 18F-FDG PET in patients with a recent ischemic stroke

Eduardo Garcı́a, Pol Camps‐Renom, Núria Puig, Alejandro Fernández‐León et autres

Abstract Background 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence. Aim Our aim was to evaluate the performance of soluble low-density lipoprotein receptor-related protein 1 (sLRP1) as an indicator of carotid plaque inflammation. Methods A prospective …

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Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response

Virginia Actis Dato, Aleyda Benitez‐Amaro, Eduardo Garcı́a, Lene Claudi et autres

BACKGROUND: Antibodies against the P3 sequence (Gly1127-Cys1140) of LRP1 (anti-P3 Abs) specifically block cholesteryl ester (CE) accumulation in vascular cells. LRP1 is a key regulator of insulin receptor (InsR) trafficking in different cell types. The link between CE accumulation and the insulin …

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Peptides against Low Density Lipoprotein (LDL) Aggregation Inhibit Intracellular Cholesteryl Ester Loading and Proliferation of Pancreatic Tumor Cells

Aleyda Benitez‐Amaro, Neus Martínez‐Bosch, Noemí Manero‐Rupérez, Lene Claudi et autres

Dyslipidemia, metabolic disorders and/or obesity are postulated as risk factors for pancreatic ductal adenocarcinoma (PDAC). The majority of patients with these metabolic alterations have low density lipoproteins (LDLs) with increased susceptibility to become aggregated in the extracellular matrix (ECM). LDL aggregation can …

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Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis

Aleyda Benitez‐Amaro, Angels Solanelles Curco, Eduardo Garcı́a, Josep Julve et autres

Apolipoprotein (Apo)-based mimetic peptides have been shown to reduce atherosclerosis. Most of the ApoC-II and ApoE mimetics exert anti-atherosclerotic effects by improving lipid profile. ApoC-II mimetics reverse hypertriglyceridemia and ApoE-based peptides such as Ac-hE18A-NH2 reduce cholesterol and triglyceride (TG) levels in humans. …

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Characterization of cholesteryl ester-loaded human coronary vascular smooth muscle cell secretome. A source of potential biomarkers of coronary artery disease

José-Román Escudero Rodríguez, Aleyda Benitez‐Amaro, Lene Claudi, Jianjiao Ni et autres

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