Tanya Sage

Recombinant von Willebrand Factor (vonicog alfa) reduces platelet inhibition caused by antiplatelet drugs and has potential as an acute haemostatic agent

Michael Desborough, Joanne L. Mitchell, Polly Whitworth, Ashifa Al Juwaiser et autres

Not available.

gb (code pays fourni par la source)

Development of Zafirlukast Analogues for Improved Antithrombotic Activity Through Thiol Isomerase Inhibition

Justine A. Keovilay, Kaitlind C. Howard, Kirk A. Taylor, Sabeeya Khan et autres

BACKGROUND: Thiol isomerases play essential and nonredundant roles in platelet activation, aggregation, and thrombus formation. Thiol isomerase inhibitors have the potential to overcome the 2 major drawbacks of current antithrombotic therapies, as they target both arterial and venous thrombosis without enhancing bleeding …

us (code pays fourni par la source)

TRIPLE Score: GPVI and CD36 Expression Predict a Prothrombotic Platelet Function Phenotype

Alexander P. Bye, Neline Kriek, Carly Kempster, Joanne L. Dunster et autres

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Multiple myeloma and its treatment contribute to increased platelet reactivity

Joanne L. Mitchell, Dalia Khan, Neline Kriek, Amanda J. Unsworth et autres

Multiple myeloma (MM) and its precursor states, smoldering myeloma (SM) and monoclonal gammopathy of undetermined significance (MGUS) are associated with increased incidence of thrombosis, however the cause of this is unknown. Lenalidomide treatment of MM substantially improves patient survival, although significantly increases …

gb (code pays fourni par la source)

Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability

Joanne L. Mitchell, Gemma Little, Alexander P. Bye, Renato Simões Gaspar et autres

Background: -antiplasmin, to increase resistance to fibrinolysis. We have previously shown that cellular FXIII (factor XIII-A [FXIII-A]), which is abundant in the platelet cytoplasm, is externalized onto the activated membrane and cross-links extracellular substrates. The contribution of cellular FXIII-A to platelet activation …

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The rate of platelet activation determines thrombus size and structure at arterial shear

Joanne L. Mitchell, Joanne L. Dunster, Neline Kriek, Amanda J. Unsworth et autres

BACKGROUND: The response of platelets to activating stimuli and pharmaceutical agents varies greatly within the normal population. Current platelet function tests are used to measure end-point levels of platelet activation without taking the speed at which platelets activate into account, potentially missing …

jp, gb (code pays fourni par la source)

Pirtobrutinib results in reversible platelet dysfunction compared to ibrutinib and acalabrutinib

Alexander P. Bye, Neline Kriek, Tanya Sage, Suzannah J. Rawlings et autres

Not available.

gb (code pays fourni par la source)

Fully automated platelet differential interference contrast image analysis via deep learning

Carly Kempster, George B. Butler, Elina Kuznecova, Kirk A. Taylor et autres

Platelets mediate arterial thrombosis, a leading cause of myocardial infarction and stroke. During injury, platelets adhere and spread over exposed subendothelial matrix substrates of the damaged blood vessel wall. The mechanisms which govern platelet activation and their interaction with a range of …

gb, us (code pays fourni par la source)

Cucurbitacins Elicit Anti-Platelet Activity via Perturbation of the Cytoskeleton and Integrin Function

Neline Kriek, Sophie H. Nock, Tanya Sage, Badrija Khalifa et autres

Cucurbitacins are dietary compounds that have been shown to elicit a range of anti-tumour, anti-inflammatory and anti-atherosclerotic activities. Originally identified as signal transducer and activator of transcription, STAT, inhibitors, a variety of mechanisms of action have since been described, including dysregulation of …

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Multiparameter phenotyping of platelet reactivity for stratification of human cohorts

Joanne L. Dunster, Alexander P. Bye, Neline Kriek, Tanya Sage et autres

Accurate and comprehensive assessment of platelet function across cohorts of donors may be key to understanding the risk of thrombotic events associated with cardiovascular disease, and, hence, to help personalize the application of antiplatelet drugs. However, platelet function tests can be difficult …

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Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets

Alexander P. Bye, Willianne Hoepel, Joanne L. Mitchell, Sophie M. Jegouic et autres

A subset of patients with coronavirus disease 2019 (COVID-19) become critically ill, suffering from severe respiratory problems and also increased rates of thrombosis. The causes of thrombosis in severely ill patients with COVID-19 are still emerging, but the coincidence of critical illness …

gb, nl, us (code pays fourni par la source)

Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets

Alexander P. Bye, Willianne Hoepel, Joanne L. Mitchell, Sophie M. Jegouic et autres

Abstract A subset of patients with COVID-19 become critically ill, suffering from severe respiratory problems and also increased rates of thrombosis. The causes of thrombosis in severely ill COVID-19 patients are still emerging, but the coincidence of critical illness with the timing …

gb, nl (code pays fourni par la source)