Dalia Khan

Risks of bleeding vs. thromboembolism in patients with mechanical valves anticoagulated with warfarin

Hannah Glatzel, Heba Nashat, Dalia Khan, Lucy Wood et autres

Anticoagulation with vitamin K antagonists is recommended for prevention of thromboembolism in patients with mechanical heart valves. However, this treatment carries a notable risk of bleeding. We performed a retrospective analysis of patients with mechanical heart valves who were anticoagulated with warfarin, …

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Massive Intramuscular Haematoma Due to Acquired Factor V Deficiency

Lara Budwig, Varvara Bashkirova, S.I. Shah, David Maudgil et autres

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Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Cole‐Sinclair et autres

Are all fibrinogen concentrates the same? The effects of two fibrinogen therapies in an afibrinogenemic patient and in a fibrinogen deficient plasma model. A clinical and laboratory case report

Soutiam Goodarzi, Jeries Abu‐Hanna, Sarah Harper, Dalia Khan et autres

The choice of treatments for inherited, or acquired, fibrinogen deficient states is expanding and there are now several fibrinogen concentrate therapies commercially available. Patients with the rare inherited bleeding disorder, afibrinogenemia, commonly require life-long replacement therapy with fibrinogen concentrate to prevent hemorrhagic …

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Surgical Outcome of Metastatic Intracranial Brain Tumors in Different Location of Brain

Dr. Md. Mahamudul Haque Morshed, Avijit Dey, Dr.Mohammad Abu Sayed Miah, Dalia Khan et autres

Background: Metastatic intracranial brain tumors are among the most common types of brain tumors, often associated with poor prognosis and significant morbidity.The purpose of the study was to assess the surgical outcomes of metastatic intracranial brain tumors in different locations of the …

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Multiple myeloma and its treatment contribute to increased platelet reactivity

Joanne Mitchell, Dalia Khan, Neline Kriek, Amanda J. Unsworth et autres

Multiple myeloma (MM) and its precursor states, smoldering myeloma (SM) and monoclonal gammopathy of undetermined significance (MGUS) are associated with increased incidence of thrombosis, however the cause of this is unknown. Lenalidomide treatment of MM substantially improves patient survival, although significantly increases …

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A case of ChAdOx1 vaccine-induced thrombocytopenia and thrombosis syndrome leading to bilateral adrenal haemorrhage and adrenal insufficiency

Agathoklis Efthymiadis, Dalia Khan, Sue Pavord, Aparna Pal

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

A case of ChAdOx1 vaccine-induced thrombocytopenia and thrombosis syndrome leading to bilateral adrenal haemorrhage and adrenal insufficiency

Agathoklis Efthymiadis, Dalia Khan, Sue Pavord, Aparna Pal

Summary: Vaccine-induced thrombosis and thrombocytopenia (VITT) after vaccination against SARS-CoV-2 with the adenoviral vector-based vaccines ChAdOx1 and Ad26.COV2.S has been associated with adrenal pathology, such as bilateral adrenal vein thrombosis, adrenal cortex haemorrhage and adrenal insufficiency in 6% of patients. We report …

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A case of ChAdOx1 vaccine-induced thrombocytopaenia and thrombosis syndrome leading to bilateral adrenal haemorrhage and adrenal insufficiency

Agathoklis Efthymiadis, Dalia Khan, Sue Pavord, Aparna Pal

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Risk of thrombosis with thrombocytopenia syndrome after COVID‐19 vaccination prior to the recognition of vaccine‐induced thrombocytopenia and thrombosis: A self‐controlled case series study in England

Hannah Higgins, Nick Andrews, Julia Stowe, Gayatri Amirthalingam et autres

Background: Several studies have found increased risks of thrombosis with thrombocytopenia syndrome (TTS) following the ChAdOx1 vaccination. However, case ascertainment is often incomplete in large electronic health record (EHR)-based studies. Objectives: To assess for an association between clinically validated TTS and COVID-19 …

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Syndrome of cerebral venous sinus thrombosis and thrombocytopenia after vaccination for COVID-19

Babak Soleimani, Sanchit Turaga, Dalia Khan, Claire Davies et autres

Abstract Experience in the management of COVID-19 vaccine induced thrombosis and thrombocytopenia is currently lacking. In this case series we report the presentation and our experience in the management of cerebral venous sinus thrombosis and thrombocytopenia post ChAdOx1 nCoV-19 vaccination. Two of …

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Prospective Study Reveals Increased Platelet Function Associated with Multiple Myeloma and Its Treatment

Dalia Khan, Joanne Mitchell, Neline Kriek, Amanda J. Unsworth et autres

Background: Multiple Myeloma (MM) is a rare incurable bone marrow cancer characterised by a malignant proliferation of plasma cells. MM is usually preceded by a premalignant and benign Monoclonal Gammopathy of Undetermined Significance (MGUS). The incidence of arterial and venous thrombosis in …

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