Elena Lesma

Jagged-dependent Notch signaling governs extracellular vesicle bioactivity in multiple myeloma

Domenica Giannandrea, Valentina Citro, Natalia Platonova, M. Colombo et autres

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Interleukin-8 and extracellular vesicles spread senescence in Lymphangioleiomyomatosis microenvironment

Clara Bernardelli, Piera Selvaggio, Giorgia Cappello, Elisabetta Di Fede et autres

The Senescence-Associated Secretory Phenotype (SASP), a hallmark of cellular senescence, is characterized by the presence of pro-inflammatory molecules, small Extracellular Vesicles (sEVs), and proteins that remodel the extracellular matrix. For this reason, SASP might contribute to the detrimental effects of senescence by …

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Exploring the uncharted role of cell senescence in rare diseases

Piera Selvaggio, Esi Taci, Alessandra Barassi, Valentina Massa et autres

BACKGROUND: Cellular senescence is a biological process in which the cell cycle is arrested in response to DNA damage caused by different endogenous and exogenous stimuli. In senescent cells, activation of intracellular cascade induces epigenetic, morphological and metabolic changes. Among them, senescent …

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p300 inhibition delays premature cellular senescence

Elisabetta Di Fede, Esi Taci, Silvia Castiglioni, Stefano Rebellato et autres

Cellular senescence represents a permanent state of cell cycle arrest, also observed in neurodegenerative disorders. As p300 has been identified as an epigenetic driver of replicative senescence, we aimed to investigate whether in vitro p300 inhibition could rescue the stress-induced premature senescence …

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Corrigendum to “Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells” [J Hazard Mater (2024) 462 132717]

Domenica Giannandrea, Marco Parolini, Valentina Citro, Beatrice De Felice et autres

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Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.

Domenica Giannandrea, Marco Parolini, Beatrice De Felice, Giulia Sauro et autres

We live in a plastic world: every day, a wide array of plastics of different compositions, shapes, and sizes contaminate the environment and enter the food chain, profoundly affecting our lives and human health. Nanoplastics (NPs) are emerging as one of our …

Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.

Domenica Giannandrea, Marco Parolini, Beatrice De Felice, Giulia Sauro et autres

We live in a plastic world: every day, a wide array of plastics of different compositions, shapes, and sizes contaminate the environment and enter the food chain, profoundly affecting our lives and human health. Nanoplastics (NPs) are emerging as one of our …

Dysfunction in IGF2R Pathway and Associated Perturbations in Autophagy and WNT Processes in Beckwith–Wiedemann Syndrome Cell Lines

Silvana Pileggi, Elisa Adele Colombo, Silvia Ancona, Roberto Quadri et autres

upregulation in BWS, focusing on insulin-like growth factor pathways, which are poorly known in this syndrome. We examined the IGF2R, the primary receptor of IGF2, WNT, and autophagy/lysosomal pathways in BWS patient-derived lymphoblastoid cell lines, showing different genetic and epigenetic defects. The …

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Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells

Domenica Giannandrea, Marco Parolini, Valentina Citro, Beatrice De Felice et autres

Our world is made of plastic. Plastic waste deeply affects our health entering the food chain. The degradation and/or fragmentation of plastics due to weathering processes result in the generation of nanoplastics (NPs). Only a few studies tested NPs effects on human …

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Dysregulated lipid metabolism in lymphangioleiomyomatosis pathogenesis as a paradigm of chronic lung diseases

Clara Bernardelli, Anna Caretti, Elena Lesma

A chronic inflammatory condition characterizes various lung diseases. Interestingly, a great contribution to inflammation is made by altered lipids metabolism, that can be caused by the deregulation of the mammalian target of rapamycin complex-1 (mTORC1) activity. There is evidence that one of …

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Primary TSC2-/meth Cells Induce Follicular Neogenesis in an Innovative TSC Mouse Model

Clara Bernardelli, Eloisa Chiaramonte, Silvia Ancona, Silvia Maria Sirchia et autres

Cutaneous lesions are one of the hallmarks of tuberous sclerosis complex (TSC), a genetic disease in which mTOR is hyperactivated due to the lack of hamartin or tuberin. To date, novel pharmacological treatments for TSC cutaneous lesions that are benign but still …

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LAM Cells as Potential Drivers of Senescence in Lymphangioleiomyomatosis Microenvironment

Clara Bernardelli, Silvia Ancona, Melania Lazzari, Antonella Lettieri et autres

Senescence is a stress-response process characterized by the irreversible inhibition of cell proliferation, associated to the acquisition of a senescence-associated secretory phenotype (SASP), that may drive pathological conditions. Lymphangioleiomyomatosis (LAM) is a rare disease in which LAM cells, featuring the hyperactivation of …

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