Silvia Ancona

Jagged-dependent Notch signaling governs extracellular vesicle bioactivity in multiple myeloma

Domenica Giannandrea, Valentina Citro, Natalia Platonova, M. Colombo et autres

it (code pays fourni par la source)

Identification of ICAM-1–targeting DNA aptamers as a host-directed strategy to inhibit Human Rhinovirus infection

Jessica Dellavedova, Chiara Campera, Silvia Ancona, Monica Rebecchi et autres

Abstract Exacerbations of respiratory viral infections significantly contribute to morbidity and healthcare burden. Among these viruses, Human Rhinoviruses (HRVs) are the most frequent causative agents of upper respiratory tract infections. To date, over 150 HRV serotypes have been identified, classified into three …

it, us (code pays fourni par la source)

Roseburia-Associated Gut–Brain Axis Alterations in Relapsing–Remitting Multiple Sclerosis: Evidence from a Household-Matched Case–Control Study

Alen Zollo, Matteo Domenico Marsiglia, Andrea Corona, Emerenziana Ottaviano et autres

Background/Objectives: Gut microbiota (GM) dysbiosis has been implicated in multiple sclerosis (MS) pathogenesis, influencing inflammation and neurodegeneration, but findings remain inconsistent due to environmental and methodological variability. This study aimed to identify possible microbial biomarkers of MS status and disease severity by …

it, us (code pays fourni par la source)

Correction: Gut microbiota signatures in tuberous sclerosis complex and epilepsy: a pilot study

Emerenziana Ottaviano, Matteo Domenico Marsiglia, Camilla Ceccarani, Silvia Ancona et autres

A correction refers to a change to their article that the author wishes to publish after publication. The publication of this article is subject to Frontiers' editorial approval.• Please read through all the templates before choosing • Pick the most relevant text …

it, us (code pays fourni par la source)

Gut Microbiota and Metabolic Modulation by Slow-Release Protein Substitutes in Phenylketonuria: Findings from the PREMP Study

Martina Tosi, Matteo Domenico Marsiglia, Emerenziana Ottaviano, Sara Parolisi et autres

Background/Objectives: Phenylketonuria (PKU) is an inherited metabolic disorder requiring early and lifelong dietary management through a low-phenylalanine (Phe) diet supplemented with Phe-free protein substitutes (PS). Recently developed slow-release PS formulations aim to mimic natural protein absorption, enhancing metabolic stability and tolerability. The …

it, us (code pays fourni par la source)

Gut microbiota signatures in tuberous sclerosis complex and epilepsy: a pilot study

Emerenziana Ottaviano, Matteo Domenico Marsiglia, Camilla Ceccarani, Silvia Ancona et autres

Objective Tuberous sclerosis complex (TSC) presents with a broad clinical spectrum. While some individuals exhibit mild symptoms, most experience seizures and neuropsychiatric comorbidities. Emerging evidence suggests that both genetic and environmental factors, including gut microbiota, may influence epilepsy susceptibility. The microbiota–gut–brain axis …

it, us (code pays fourni par la source)

p300 inhibition delays premature cellular senescence

Elisabetta Di Fede, Esi Taci, Silvia Castiglioni, Stefano Rebellato et autres

Cellular senescence represents a permanent state of cell cycle arrest, also observed in neurodegenerative disorders. As p300 has been identified as an epigenetic driver of replicative senescence, we aimed to investigate whether in vitro p300 inhibition could rescue the stress-induced premature senescence …

it, us (code pays fourni par la source)

Effectiveness of Anti-SARS-CoV-2 monoclonal antibodies in real-life: RNAemia and clinical outcomes in high-risk COVID-19 patients

Matteo Domenico Marsiglia, Silvia Bianchi, Francesca Bai, Camilla Tincati et autres

BACKGROUND: Anti-SARS-CoV-2 neutralizing monoclonal antibodies (mAbs) have been shown to have clinical benefits in treating high-risk patients with mild-moderate COVID-19. SARS-CoV-2 RNA in serum (RNAemia), is usually associated with severe disease and deaths. This study evaluates real-life data on the effectiveness of …

it, us (code pays fourni par la source)

Pilocarpine inhibits Candida albicans SC5314 biofilm maturation by altering lipid, sphingolipid, and protein content

Emerenziana Ottaviano, Michele Dei, Silvia Ancona, Francesca Triva et autres

ABSTRACT Candida albicans filamentation and biofilm formation are key virulence factors tied to tissue invasion and antifungal tolerance. Pilocarpine hydrochloride (PHCl), a muscarinic receptor agonist, inhibits biofilm maturation, although its mechanism remains unclear. We explored PHCl effects by analyzing sphingolipid and lipid …

it (code pays fourni par la source)

Expanding the clinical spectrum of PPP3CA variants - alternative isoforms matter

Silvia Castiglioni, Laura Pezzoli, Lidia Pezzani, Antonella Lettieri et autres

BACKGROUND: the protein phosphatase 3 catalytic subunit alpha (PPP3CA) gene encodes for the alpha isoform of the calcineurin catalytic subunit, which controls the phosphorylation status of many targets. Currently, 23 pathogenic variants of PPP3CA are known, with clinical manifestations varying by mutation …

it (code pays fourni par la source)

POS0767 CLINICAL AND SEROLOGICAL FEATURES OF PAEDIATRIC SJOGREN’S DISEASE AND COMPARISON WITH ADULT PATIENTS: A MULTICENTRE ITALIAN STUDY

F. Riccio, Silvia Ancona, Saviana Gandolfo, Angela Pistorio et autres

it (code pays fourni par la source)

Dysfunction in IGF2R Pathway and Associated Perturbations in Autophagy and WNT Processes in Beckwith–Wiedemann Syndrome Cell Lines

Silvana Pileggi, Elisa Adele Colombo, Silvia Ancona, Roberto Quadri et autres

upregulation in BWS, focusing on insulin-like growth factor pathways, which are poorly known in this syndrome. We examined the IGF2R, the primary receptor of IGF2, WNT, and autophagy/lysosomal pathways in BWS patient-derived lymphoblastoid cell lines, showing different genetic and epigenetic defects. The …

it (code pays fourni par la source)