Eloisa Chiaramonte

Primary TSC2-/meth Cells Induce Follicular Neogenesis in an Innovative TSC Mouse Model

Clara Bernardelli, Eloisa Chiaramonte, Silvia Ancona, Silvia Maria Sirchia et autres

Cutaneous lesions are one of the hallmarks of tuberous sclerosis complex (TSC), a genetic disease in which mTOR is hyperactivated due to the lack of hamartin or tuberin. To date, novel pharmacological treatments for TSC cutaneous lesions that are benign but still …

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Differential Modulation of Matrix Metalloproteinases-2 and -7 in LAM/TSC Cells

Silvia Ancona, Emanuela Orpianesi, Clara Bernardelli, Eloisa Chiaramonte et autres

Matrix metalloproteinase (MMP) dysregulation is implicated in several diseases, given their involvement in extracellular matrix degradation and cell motility. In lymphangioleiomyomatosis (LAM), a pulmonary rare disease, MMP-2 and MMP-9 have been detected at high levels in serum and urine. LAM cells, characterized …

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Role of Prolactin Receptors in Lymphangioleiomyomatosis

Amira Alkharusi, Elena A. Lesma, Silvia Ancona, Eloisa Chiaramonte et autres

Pulmonary lymphangioleiomyomatosis (LAM) is a rare lung disease caused by mutations in the tumor suppressor genes encoding Tuberous Sclerosis Complex (TSC) 1 and TSC2. The protein product of the TSC2 gene is a well-known suppressor of the mTOR pathway. Emerging evidence suggests …

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Anti-EGFR Antibody Reduces Lung Nodules by Inhibition of EGFR-Pathway in a Model of Lymphangioleiomyomatosis

Elena A. Lesma, Eloisa Chiaramonte, Silvia Ancona, Emanuela Orpianesi et autres

EGFR belongs to the HER/ErbB family of tyrosine kinase receptors and its activation in cancer cells has been linked with increased proliferation, angiogenesis, and metastasis. Lymphangioleiomyomatosis (LAM) is a rare, low-grade neoplasm that occurs sporadically or in association with tuberous sclerosis complex …

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TSC 2 epigenetic defect in primary LAM cells. Evidence of an anchorage‐independent survival

Elena A. Lesma, Silvia Ancona, Silvia Maria Sirchia, Emanuela Orpianesi et autres

Tuberous sclerosis complex (TSC) is caused by mutations in TSC1 or TSC2 genes. Lymphangioleiomyomatosis (LAM) can be sporadic or associated with TSC and is characterized by widespread pulmonary proliferation of abnormal α-smooth muscle (ASM)-like cells. We investigated the features of ASM cells …

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Development of a Lymphangioleiomyomatosis Model by Endonasal Administration of Human TSC2−/− Smooth Muscle Cells in Mice

Elena A. Lesma, Eloisa Chiaramonte, Eleonora Isaia, Vera Grande et autres

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A Mouse LAM Model By Endonasal Administration Of Human TSC2 Deficient Smooth Muscle Cells

Elena A. Lesma, Eloisa Chiaramonte, Silvia Ancona, Vera Grande et autres