RAJ KUMAR PANDITA

Impact of Transposable Elements on DNA Double-Strand Break Repair and Genomic Stability

Mohd Iqbal Bhat, RAJ KUMAR PANDITA, Arjamand Mushtaq, Ulfat S. Mir et autres

Transposable elements (TEs) are indispensable components of eukaryotic genomes, mechanistically linked to carcinogenesis, aging and other degenerative diseases. The ability of TEs to self-propagate and cause deletions, inversions or insertions within the genome poses a real threat to the fidelity of genomic …

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Correction: β2-spectrin depletion impairs DNA damage repair

Nobuo Horikoshi, RAJ KUMAR PANDITA, Kalpana Mujoo, Shashank Hambarde et autres

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HP1β recruits RING1A to ubiquitinate histone H2A for BRCA1-mediated resection of double-stand breaks

Vijaya Charaka, RAJ KUMAR PANDITA, Chi-Lin Tsai, Xiaoyan Aria Wang et autres

Efficient DNA double-strand break (DSB) repair by homologous recombination (HR), as initiated by BRCA1 recruitment orchestrated by histone and non-histone proteins, is critical to genome stability, replication, transcription, and cancer avoidance. Here we reveal Heterochromatin Protein1 beta (HP1β) promotes BRCA1 enrichment at …

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A predictive chromatin architecture nexus regulates transcription and DNA damage repair

Audesh Bhat, Sonali Bhan, Aindrila Kabiraj, RAJ KUMAR PANDITA et autres

Genomes are blueprints of life essential for an organism's survival, propagation, and evolutionary adaptation. Eukaryotic genomes comprise of DNA, core histones, and several other nonhistone proteins, packaged into chromatin in the tiny confines of nucleus. Chromatin structural organization restricts transcription factors to …

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HP1β Recruits HP1β to Ubiquitinate Histone H2A for BRCA1 Mediated Resection of Double-Stand Breaks

Vijay Charaka, RAJ KUMAR PANDITA, Chi-Lin Tsai, Xiaoyan Wang et autres

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Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons

Subrata Pradhan, Keegan M. Bush, Nan Zhang, RAJ KUMAR PANDITA et autres

SUMMARY Persistent DNA double-strand breaks (DSBs) are enigmatically implicated in neurodegenerative diseases including Huntington’s disease (HD), the inherited late-onset disorder caused by CAG repeat elongations in Huntingtin (HTT). Here we combine biochemistry, computation and molecular cell biology to unveil a mechanism whereby …

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The future of cancer treatment: combining radiotherapy with immunotherapy

Gunjan Dagar, Ashna Gupta, Abhishek Shankar, Ravi Chauhan et autres

Radiotherapy (RT) and immunotherapy (IT) are the powerful tools for cancer treatment which act through the stimulation of immune response, and evidence suggest that combinatorial actions of these therapies may augment each other's beneficial effect through complex synergistic mechanisms. These molecular strategies …

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Correction: The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Arpita Chatterjee, Saikat Saha, Anirban Chakraborty, Anabela Silva‐Fernandes et autres

After this article [1] was published, concerns were raised that the PNKP panel in Fig 2A appears similar to the PNKP panel in Fig 2B when the aspect ratio is adjusted.In response, the corresponding author stated that the PNKP panels in Fig …

Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression

Ravi Chauhan, Ashna Gupta, Lakshay Malhotra, Ajaz Ahmad Bhat et autres

BACKGROUND: Osteosarcoma is a type of bone cancer that predominantly affects young individuals, including children and adolescents. The disease progresses through heterogeneous genetic alterations, and patients often develop pulmonary metastases even after the primary tumors have been surgically removed. Ubiquitin-specific peptidases (USPs) …

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Data from CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Mayur A. Gadhikar, Jiexin Zhang, Li Shen, Xiayu Rao et autres

Abstract Checkpoint kinase inhibitors (CHKi) exhibit striking single-agent activity in certain tumors, but the mechanisms accounting for hypersensitivity are poorly understood. We screened a panel of 49 established human head and neck squamous cell carcinoma (HNSCC) cell lines and report that nearly …

Figure S5 from CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Mayur A. Gadhikar, Jiexin Zhang, Li Shen, Xiayu Rao et autres

This file contains data showing impact of roscovitine co-treatment on the cell cycle responses of hypersensitive cells following Chk1 inhibition and a theoretical model explaining basis for prexasertib sensitivity in HNSCC cells. This file is linked to main figure 6.

Figure S4 from CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Mayur A. Gadhikar, Jiexin Zhang, Li Shen, Xiayu Rao et autres

This file contains data showing relationship between cdk2 activity and Chk1 inhibition in hypersensitive UMSCC1-mVenus and least sensitive HN31-mVenus cells. This file is linked to main figure 5.