Correction: The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Le résumé fourni par la source

After this article [1] was published, concerns were raised that the PNKP panel in Fig 2A appears similar to the PNKP panel in Fig 2B when the aspect ratio is adjusted.In response, the corresponding author stated that the PNKP panels in Fig 2A and 2B show apparent resemblance, but are not duplicates, and they were derived from two separate gels representing different experimental conditions and developed on the same X-ray film.The PLOS Editors consider the concern resolved following assessment of the data files (S1 File).In preparing the panel for purified full-length and individual PNKP domains in Fig 2D, a lane with purified full length PNKP was removed between lanes two and three (original Coomassie stained SDS-PAGE image is in S2 File).An updated version of Fig 2 is presented here to clearly indicate the cut position with a vertical black line.Underlying data for results reported in this article are in S1-S8 Files.The image data underlying the PNKP panels in Fig 2A-2B, Fig 2D, the autoradiographic images in Figs 3A-B and 4B, the top panel in Fig 6A, and the autoradiographic image in S6B Fig have been reviewed by PLOS.The corresponding author stated that the individual-level data underlying S6 and S9 Figs are no longer available.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.