Jianxin Wan

Selective glomerular hypofiltration syndrome: a novel renal phenotype associated with cardiovascular disease and adverse outcomes in diabetic kidney disease

Yuan Fang, Xiaodan Guo, Liuting Zhong, Xinyan He et autres

INTRODUCTION: Selective glomerular hypofiltration syndrome (SGHS), defined by a low ratio of estimated glomerular filtration rate using cystatin C (eGFRcys) to estimated glomerular filtration rate using creatinine (eGFRcr), has emerged as a novel kidney dysfunction phenotype. Its role in diabetic kidney disease …

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FBP1 Is Associated with Attenuated Mitochondrial Injury in Renal Tubular Epithelial Cells of Diabetic Kidney Disease via Modulation of Lactate Metabolism

Siyi Rao, Mengjie Weng, Yongjie Zhuo, Jiaqun Lin et autres

The role of gluconeogenesis in kidney disease has increasingly drawn attention. Fructose-1,6-bisphosphatase 1 (FBP1) is a key rate-limiting enzyme in gluconeogenesis that suppresses glycolysis and reduces lactate production. In this study, we first analyzed public transcriptomic datasets of diabetic kidney disease (DKD) …

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Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis

Dong Fu-xing, Zheng Lu-li, Kun Nie, Jianxin Wan

BACKGROUND Peritoneal dialysis represents one of the primary alternative therapies for end-stage renal disease. Peritoneal fibrosis (PF) may, however, develop as a consequence of the peritoneum being exposed to non-physiological peritoneal dialysis fluid over extended durations. PF is the main factor that …

C3a/C3aR axis is involved in diabetic kidney injury by regulating podocyte mitophagy in diabetic nephropathy

Mengjie Weng, Xiaoting Wu, Siyi Rao, Kun Nie et autres

The C3a/C3aR axis has been confirmed to be associated with the pathogenesis of diabetic nephropathy (DN) and mitochondrial dysfunction; however, the exact mechanisms underlying its role in diabetic podocytopathy remain unclear. The present study investigated the involvement of C3a/C3aR signaling in regulating …

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Risk prediction model for progression of type 2 diabetic nephropathy with and without metabolic syndrome: a retrospective cohort study

Yuan Fang, Siyi Rao, Yongjie Zhuo, Jiaqun Lin et autres

Objectives: To construct a risk prediction model for type 2 diabetic nephropathy (T2DN) progression in patients with and without metabolic syndrome (MetS). Methods: In this retrospective study, we enrolled 130 T2DN patients diagnosed by renal biopsy. The clinicopathological characteristics of participants were …

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A novel encrypted traffic detection model based on detachable convolutional GCN-LSTM

Xiaogang Yuan, Jianxin Wan, Dezhi An, Huan Pei

With the widespread adoption of network encryption technologies, traditional detection methods increasingly struggle to identify malicious encrypted traffic due to their limited ability to capture structural and behavioral characteristics. To address this issue, this paper proposes a Detachable Convolutional GCN-LSTM (DC-GL) model. …

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Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy

Song Jiang, Hanying Jia, Qing Hou, Jing Li et autres

The genetic etiology of diabetic nephropathy (DN) is masked by inaccurate phenotyping and ethnic disparities. Here, we conduct a stepwise genome-wide association study (GWAS) in the Chinese Han population, using a precise phenotype of biopsy-proven DN as cases, patients with type 2 …

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0319 Impact of dupilumab on the atopic march in pediatric patients

Denise Ann Tsang, J. Takeshita, Jianxin Wan

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Development and validation of a predictive nomogram for differentiating diabetic nephropathy from non-diabetic nephropathy in patients with T2DM: a multicenter study

Zishan Lin, Tao Hong, Wenfeng Wang, Shidong Xie et autres

Background: Type 2 diabetes mellitus (T2DM) significantly exacerbates the global health burden, with diabetic nephropathy (DN) emerging as one of the most common causes of chronic kidney disease. In T2DM patients with kidney disease, it is particularly important to distinguish DN from …

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KLF15 deficiency contributes complement activation and podocyte injury in IgA nephropathy via regulating p300/ NF-κB axis

Weiyuan Lin, Shanhong Shi, Yanling Zheng, Jiong Cui et autres

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Association between physiological serum total bilirubin concentrations and the progression of diabetic nephropathy

Chenhui Zhang, Yuan Fang, Zishan Lin, Yongjie Zhuo et autres

Purpose To analyze the relationship between physiological serum total bilirubin (STB) concentrations and the progression of diabetic nephropathy (DN). Methods The clinical features and pathological data of 159 patients with diabetic nephropathy confirmed by renal biopsy were retrospectively analyzed. They were divided …

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Risk factors and predictive model for renal outcomes in autoimmune membranous nephropathy with and without acute kidney injury: a retrospective cohort study

Zhenzhou Li, Liyan Yang, Mengjie Weng, Jiaqun Lin et autres

Objective This study aimed to delineate the risk factors affecting renal outcomes in autoimmune membranous nephropathy (aMN) with or without acute kidney injury (AKI) and develop a predictive model. Methods This retrospective cohort study included 441 patients with biopsy-confirmed aMN from the …

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