Dong Fu-xing

Pyruvate alleviates traumatic brain injury by suppressing glutamate-driven ferroptosis via the xCT/GPX4 axis

Jinxia Kuai, Han-bo Zuo, X Fang, Jin-Jing Hao et autres

Traumatic brain injury (TBI) triggers toxic glutamate release and ferroptosis, contributing to neuronal death. This study investigated whether sodium pyruvate confers neuroprotection by reducing central glutamate and inhibiting ferroptosis. Using a murine TBI model, we found that pyruvate treatment rapidly lowered serum …

cn (code pays fourni par la source)

Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis

Dong Fu-xing, Zheng Lu-li, Kun Nie, Jianxin Wan

BACKGROUND Peritoneal dialysis represents one of the primary alternative therapies for end-stage renal disease. Peritoneal fibrosis (PF) may, however, develop as a consequence of the peritoneum being exposed to non-physiological peritoneal dialysis fluid over extended durations. PF is the main factor that …