Yuan Fang

Radiation-induced skin injury: a review of pathophysiology, assessment, management, and re-irradiation protocols

Jiao Cheng, Juancong Dong, Yuan Fang, Xiaoquan Zhang et autres

Background: Radiation-induced skin injury (RISI) is a common dose-limiting toxicity of radiotherapy, characterized by erythema, desquamation, fibrosis, atrophy, and ulceration. It results from DNA damage, reactive oxygen species, and dysregulated inflammation. Purpose: This review synthesizes current knowledge on the mechanisms, assessment tools, …

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Bibliometric analysis and recent trends on tyrosine kinase inhibitors in leukemia

Jiao Cheng, Yuan Fang, Juancong Dong, Xiaoquan Zhang et autres

BACKGROUND: Leukemia treatment has been revolutionized by tyrosine kinase inhibitors (TKIs), but comprehensive understanding of the global research landscape remains fragmented. This study aims to provide a systematic bibliometric analysis of TKIs research in leukemia to identify research trends, collaboration patterns, and …

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Association between fat-to-muscle ratio and diabetic kidney disease: a nationwide NHANES analysis with real-world validation

Xiaohong Zhang, Jiaqun Lin, Wenfeng Wang, Zishan Lin et autres

Background Obesity and abnormal body composition are recognized contributors to diabetic kidney disease (DKD) development. The fat-to-muscle mass ratio (FMR), an indicator of body composition, remains insufficiently studied in relation to DKD risk. Methods This study was a nationwide cohort analysis utilizing …

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Development and external validation of a prognostic model for new-onset atrial fibrillation complicating acute myocardial infarction: insights from the NOAFCAMI-China registry

Jiachen Luo, Xiaoming Qin, Yuan Fang, Xingxu Zhang et autres

AIMS: There is no specifically developed model to predict the risk of major adverse cardiac events (MACEs) in patients with new-onset atrial fibrillation (NOAF) complicating acute myocardial infarction (AMI). We aimed to develop and validate a prediction model for 5-year risk of …

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Risk prediction model for progression of type 2 diabetic nephropathy with and without metabolic syndrome: a retrospective cohort study

Yuan Fang, Siyi Rao, Yongjie Zhuo, Jiaqun Lin et autres

Objectives: To construct a risk prediction model for type 2 diabetic nephropathy (T2DN) progression in patients with and without metabolic syndrome (MetS). Methods: In this retrospective study, we enrolled 130 T2DN patients diagnosed by renal biopsy. The clinicopathological characteristics of participants were …

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Association between physiological serum total bilirubin concentrations and the progression of diabetic nephropathy

Chenhui Zhang, Yuan Fang, Zishan Lin, Yongjie Zhuo et autres

Purpose To analyze the relationship between physiological serum total bilirubin (STB) concentrations and the progression of diabetic nephropathy (DN). Methods The clinical features and pathological data of 159 patients with diabetic nephropathy confirmed by renal biopsy were retrospectively analyzed. They were divided …

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Influence of Left Ventricular Mass Index on Clinical Outcomes in Patients with Acute Myocardial Infarction

Jiachen Luo, Wentao Shi, Xingxu Zhang, Yuan Fang et autres

The aim of this study was to analyze the correlation between left ventricular mass index (LVMI) and the prognosis of patients with acute myocardial infarction (AMI).The study retrospectively analyzed the Registry of New-onset Atrial Fibrillation Complicating Acute Myocardial Infarction-Shanghai database and included …

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Association between constipation and the urine albumin-to-creatinine ratio in adults: the NHANES 2009–2010

Yuying Yang, Siyi Rao, Yongjie Zhuo, Yuan Fang et autres

Objective This study aimed to analyze the association between constipation and the urine albumin-to-creatinine ratio (ACR) using data from the National Health and Nutrition Examination Survey (NHANES) 2009–2010. Methods In this cross-sectional study, a sample of 4,282 adults aged 20 and older …

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Systemic immune-inflammation index as an independent risk factor for diabetic nephropathy: a retrospective, single-center study

Xiaohong Zhang, Yuan Fang, Mengjie Weng, Caiming Chen et autres

Purpose Systemic immune-inflammation index (SII) was an indicator which could reflect immune response and systemic inflammation. We aim to explore the relationship between SII and diabetic nephropathy (DN). Methods SII was calculated as neutrophil count × platelet count/lymphocyte count. The receiver operating …

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Prognostic implications of the 4S-AF scheme to characterize new-onset atrial fibrillation after myocardial infarction

Jiachen Luo, Zhiqiang Li, Xiaoming Qin, Xingxu Zhang et autres

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Risk Factors for Progression of CKD with and without Diabetes

Xiaohong Zhang, Yuan Fang, Zhenhuan Zou, Pianpian Hong et autres

Objective. We aim to identify independent risk factors to predict CKD progression to end stage renal disease (ESRD) in patients with or without diabetes. Methods. In this retrospective study, we enrolled CKD stage 3-4 patients between January 2013 and December 2018 and …

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Melatonin improves endometrial receptivity of adenomyosis mice via the NF-κB signaling pathway

Kunming Li, Xiaohong Guan, Dan Liu, Hong Zhou et autres

Abstract Background: Adenomyosis is a benign gynecological disorder but has detrimental effect on female fertility of childbearing age. Melatonin is a classic antioxidant and free radical scavenger to protect against tissue damage, and exerts important roles in reproductive systems. The effects of …

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