Wenfeng Wang

Analytical performance evaluation of MAGLUMI HBeAg and anti-HBe chemiluminescence immunoassays and comparison with the Abbott assays

Jingfeng Zeng, Xin Zhao, Wenfeng Wang, Ju Wang et autres

Background: Hepatitis B e antigen (HBeAg) and its corresponding antibody (anti-HBe) serve as critical serological markers in the evaluation and therapeutic management of Hepatitis B virus (HBV) infection. Study design: This retrospective study was designed to evaluate the performance of the newly …

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Zingerone alleviates diabetic nephropathy by interrupting the ER stress-inflammation-apoptosis cascade in streptozotocin-induced diabetic mice

Bi Ke, xiaojing xiong, Chen Wang, Xiuyuan Feng et autres

Endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate the protective effects of zingerone on the kidney and elucidate the underlying mechanisms in streptozotocin (STZ)-induced diabetic mice. Diabetic mice were …

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Multimodal Mixture-of-Experts: From Sparse Scaling to Conditional Specialization

Cheng Xu, Jiacheng Liu, Xinfeng Xia, Haozhe Wei et autres

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Chromosome-level genome assembly of predatory ladybug Coccinella transversoguttata

Dong Xiang, Jinge Yuan, Zhen Wang, Mengmeng Zhao et autres

Coccinella transversoguttata is a crucial beneficial insect within Coccinellidae, playing a significant role in biological pest control and maintaining ecological balance. Given its adaptability to agricultural ecosystems and natural regulation of pest populations, C. transversoguttata could serve as a valuable model for …

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A Metastasis-competent CAF Subpopulation Defined by MFAP5⁺THY1⁺ Co-expression Drives Prostate Cancer Metastasis via EMT Activation

Yongqiang Huang, Yu Wang, Wei Zhang, Wenfeng Wang et autres

BACKGROUND: The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), contributes to prostate cancer (PCa) metastasis, however, the role of CAF heterogeneity remains incompletely characterized. The study aims to identify and functionally characterize a metastasis-competent CAF subpopulation in PCa and evaluate its potential as …

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Protection against H9N2 challenge in chickens via Salmonella with a focA mutation delivered by a dendritic cell-targeted avian influenza virus NA protein tetramer

Chongbo Ge, Yan Sun, Qiyu Guo, Gerui Zhang et autres

ABSTRACT Vaccination is considered one of the most effective methods for preventing avian influenza. The influenza neuraminidase (NA) enzyme is a promising candidate for a conserved influenza vaccine, offering long-term and effective cross-protection against the disease. The aim of this study is …

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MoE-Prism: Disentangling Monolithic Experts for Elastic MoE Services via Model-System Co-Designs

Xinfeng Xia, Xiaofeng Hou, Jiacheng Liu, Peng Tang et autres

Mixture-of-Experts (MoE) scales model capacity through sparse activation, and is becoming an important architecture for large language models (LLMs). However, existing MoE serving systems typically execute all requests under a fixed routing configuration, limiting their ability to exploit heterogeneous computation requirements across …

Effect of Accelerators on Hydrothermal Anaerobic Digestion of Platanus Orientalis Linn Fallen Leaves

Hui Min Tan, Hongyu Huo, Jun Zhou, Mingjing Li et autres

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TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis

Han Yao, Yichao Hou, Kun Zhou, Liang Yu et autres

Disrupting DNA replication has been employed for treating cancers. In the present study, we found that Tripartite motif containing 21 (TRIM21) was highly expressed in colorectal cancer (CRC) and could be valuable for predicting the prognosis of CRC patients. Further study demonstrated …

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M1-like macrophages regulate T cell infiltration in colorectal cancer through P2X4 receptor

Kun Zhou, Xintian Zhang, Liang Yu, Han Yao et autres

but also augmented T cell responses in a syngeneic CRC mouse model. Clinically, reduced P2X4 expression in CRC tissues correlated with poorer prognosis. In conclusion, these findings identify the P2X4R as a key regulator of M1-like TAM polarization, representing a promising target …

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Effect of hydrothermal pretreatment on the biogas production performance of co-digestion of Chlorella and sludge

M. Li, Minghui Zhou, Lei Gong, Jiahui Zhu et autres

To address growing energy demand and promote environmental sustainability, the development of diverse biomass-based renewable energy is crucial. Co-digestion of Chlorella and sludge has been recognized as an effective strategy to improve methane production efficiency from biomass. This study aimed to explore …

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Enhanced protective efficacy of a dendritic cell-targeting truncated F protein delivery via minicircle DNA vaccine against genotype VII newcastle disease virus in chickens

Meiying Bao, Wenfeng Wang, Yan Sun, Yuhang Zhang et autres

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