Accès ouvert
2025
article
OpenAlex
Hisham Mazal, Franz-Ferdinand Wieser, Daniel Bollschweiler, Alexandra Schambony et autres
Investigations based on cryo-electron microscopy (cryo-EM), atomic force microscopy, and super-resolution microscopy reveal a symmetric trimer with propeller-like blades for the mechanosensitive ion channel PIEZO. However, a conclusive understanding of its conformations in the cell membrane is lacking. Here, we implement a …
de
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Stanislava Dimitrova Popova, Prabesh Bhattarai, Elanur Yılmaz, Daniela Lascu et autres
Microproteins, short functional peptides encoded by small genes, are emerging as critical regulators of cellular processes, yet their roles in mitochondrial function and neurodegeneration remain underexplored. In this study, we identify NCBP2-AS2 as an evolutionarily conserved mitochondrial microprotein with significant roles in …
de, us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Hisham Mazal, Alexandra Schambony, Vahid Sandoghdar
Abstract Despite the impressive progress in molecular biochemistry and biophysics, many questions regarding the conformational states of large (transmembrane) protein complexes persist. In the case of the PIEZO protein, investigations by cryogenic electron microscopy (Cryo-EM) and atomic force microscopy (AFM) have established …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Thuong Trinh‐Minh, Chih-Wei Chen, Cuong Tran Manh, Yinan Li et autres
Transforming growth factor β (TGF-β) signaling is a core pathway of fibrosis, but the molecular regulation of the activation of latent TGF-β remains incompletely understood. Here, we demonstrate a crucial role of WNT5A/JNK/ROCK signaling that rapidly coordinates the activation of latent TGF-β …
de, cn, tw, ch
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Cornelia Holler, Richard W. Taylor, Alexandra Schambony, Leonhard Möckl et autres
Delivery of very small amounts of reagents to the near-field of cells with micrometer spatial precision and millisecond time resolution is currently out of reach. Here we present μkiss as a micropipette-based scheme for brushing a layer of small molecules and nanoparticles …
de
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Vahid Sandoghdar, Cornelia Holler, Richard W. Taylor, Alexandra Schambony et autres
de
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Richard W. Taylor, Cornelia Holler, Reza Gholami Mahmoodabadi, Michelle Küppers et autres
The mobility of proteins and lipids within the cell, sculpted oftentimes by the organization of the membrane, reveals a great wealth of information on the function and interaction of these molecules as well as the membrane itself. Single particle tracking has proven …
de
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Lisa Ebersberger, Torben Schindler, Sonja A. Kirsch, Kristýna Pluháčková et autres
Lipids and proteins, as essential components of biological cell membranes, exhibit a significant degree of freedom for different kinds of motions including lateral long-range mobility. Due to their interactions, they not only preserve the cellular membrane but also contribute to many important …
de, fr
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Richard W. Taylor, Cornelia Holler, Reza Gholami Mahmoodabadi, Michelle Küppers et autres
The mobility of proteins and lipids within the cell, sculpted oftentimes by the organisation of the membrane, reveals a great wealth of information on the function and interaction of these molecules as well as the membrane itself. Single particle tracking has proven …
de
(code pays fourni par la source)
2020
conference-paper
OpenAlex
Peter N. Dietrich, Laura Wormser, Vanessa Fritz, Tatjana Seitz et autres
Background Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest cancer types worldwide. Due to globally increasing risk factors including metabolic disorders, the incidence rates of HCC are still rising. However, the molecular hallmarks of HCC remain poorly understood. …
de, ru, at
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Peter N. Dietrich, Laura Wormser, VALERIE K. FRITZ, Tatjana Seitz et autres
Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest cancer types worldwide. As a result of globally increasing risk factors including metabolic disorders, the incidence rates of HCC are still rising. However, the molecular hallmarks of HCC remain poorly …
de
(code pays fourni par la source)
2020
conference-paper
OpenAlex
Michelle Küppers, Anna D. Kashkanova, Jennifer J. Lühr, David Albrecht et autres
The combination of interferometric scattering microscopy (iSCAT) in wide-field and confocal detection reveals new prospects for the label-free visualization of subcellular processes and tracking of nanoscopic matter such as viruses, vesicles and lipid droplets.
de
(code pays fourni par la source)