Vahid Sandoghdar

Nano–electron volt Fourier-limited transition of a single surface-adsorbed molecule

Masoud Mirzaei, Alexey Shkarin, Burak Gurlek, Johannes Zirkelbach et autres

High-resolution spectroscopy allows the probing of weak interactions and subtle phenomena. Although such measurements are routinely performed in the gas phase and in crystalline materials, studies of adsorbed species on surfaces have previously fallen short of the ultimate spectral resolution, where dephasing …

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Data for the article "Nano-electronvolt Fourier-limited transition of a single surface-adsorbed molecule"

Masoud Mirzaei, Alexey Shkarin, Burak Gurlek, Johannes Zirkelbach et autres

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Data for the article "Nano-electronvolt Fourier-limited transition of a single surface-adsorbed molecule"

Masoud Mirzaei, Alexey Shkarin, Burak Gurlek, Johannes Zirkelbach et autres

de (code pays fourni par la source)

Characterization of Nanoparticles in Suspension by Simultaneous iNTA and Fluorescence Detection with Single-Molecule Sensitivity

Shuhan Jiang, Anna D. Kashkanova, Hannarae Lee, Morgan E. C. Miller et autres

Abstract Quantitative knowledge of nanoparticle properties is desirable in a large number of scientific and technological applications, but measurements with a high degree of precision usually prove to be challenging. Among a range of available methodologies, optical techniques with single particle sensitivity …

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Cryogenic light microscopy of vitrified samples with angstrom precision

Hisham Mazal, Franz-Ferdinand Wieser, Daniel Bollschweiler, Vahid Sandoghdar

High-resolution studies in structural biology are often limited by the challenges of crystallization and low contrast in the cellular native environment. The exquisite labeling specificity of fluorescence microscopy gets around these issues and allows superresolution microscopy, but to date, these works have …

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Red blood cell-derived extracellular vesicles as biomaterials: the opportunity of freezing-induced accelerated aging

Lucia Paolini, Miriam Ramos Romano, Valentina Mangolini, Selene Tassoni et autres

Red blood cell-derived extracellular vesicles (RBC-EVs) are emerging as promising biomaterials for next-generation drug delivery, owing to their intrinsic biocompatibility, immune-evasion properties, and minimal oncogenic risk. However, their broader application is currently limited by unresolved challenges related to heterogeneity, reproducibility, and long-term …

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Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy

Carla M. Brunner, Lorenz Pietsch, Ingo vom Sondern, Michael Röhrl et autres

Over recent decades, the glycocalyx, an extracellular organelle composed of a multitude of glycolipids, glycoproteins, proteoglycans, and glycoRNA, has gained considerable interest in cellular biology. While research in this field has revealed its tremendous importance in ever more aspects of physiological and …

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Cryo–light microscopy with angstrom precision deciphers structural conformations of PIEZO1 in its native state

Hisham Mazal, Franz-Ferdinand Wieser, Daniel Bollschweiler, Alexandra Schambony et autres

Investigations based on cryo-electron microscopy (cryo-EM), atomic force microscopy, and super-resolution microscopy reveal a symmetric trimer with propeller-like blades for the mechanosensitive ion channel PIEZO. However, a conclusive understanding of its conformations in the cell membrane is lacking. Here, we implement a …

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Red blood Cell-derived Extracellular Vesicles as biomaterials: the opportunity of freezing-induced accelerated aging

Lucia Paolini, Miriam Ramos Romano, Valentina Mangolini, Selene Tassoni et autres

Abstract Red blood cell-derived extracellular vesicles (RBC-EVs) are emerging as promising biomaterials for next-generation drug delivery, due to their inherent biocompatibility, immune evasion capabilities, and minimal oncogenic risk. However, their clinical translation remains limited by unresolved challenges related to heterogeneity, reproducibility, and …

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Imaging single ion channels via their Rayleigh scattering

Vahid Sandoghdar

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Hybridization of molecules via a common photonic mode

Jahangir Nobakht, André Pscherer, Jan Renger, Stephan Götzinger et autres

Atoms and molecules usually hybridize and form bonds when they come in very close proximity of each other. In this work, we show that molecules can hybridize even through far-field electromagnetic interactions mediated by the shared mode of an optical microcavity. We …

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Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome

Leila Pourtalebi Jahromi, Benedikt Kronast, Jennifer Munkert, Lorenzo Sana et autres

Antibiotic-resistant pathogens are a global health challenge, necessitating innovative solutions beyond conventional antibiotics. This study introduces biomimetic nanocarriers - hybrids of bacteriomimetic liposomes and biocompatible Myxobacteria outer-membrane vesicles (OMVs) - as tunable platforms for targeted antibiotic delivery. Comparative analyses of their physicochemical …

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