Nelly Babayan

Laser-Generated Ultrashort Pulsed Electron Beams Induce p53-Related Alteration of DNA Repair and Cell Death Pathways in Non-Small Cell Lung Cancer Cells

Margarita Pustovalova, Polina Pugacheva, Natalia Vorobyeva, Nelly Babayan et autres

Laser-driven accelerated particle beams have significantly advanced cancer treatment by facilitating the delivery of exceptionally high dose rates of radiation to solid tumors within femto- to picosecond timescales. This investigation compared the radiobiological effectiveness of ultrashort pulsed electron beams, generated by the …

ru, am (code pays fourni par la source)

AREAL facility as a source of ultrashort pulsed electron beams and its contribution to radiobiological studies

Lyudmila Nersesova, Елена В. Калита, Bagrat Grigoryan, A. Vardanyan et autres

Purpose The purpose of this review was to summarize recent studies on the radiobiological effects of ultra-short pulsed electron beams and to determine whether intra-pulse parameters, such as dose-per-pulse and pulse width, may underlie the FLASH effect more than mean dose-rate. The …

ua, am (code pays fourni par la source)

Genomic instability and molecular dysregulation in long-term residents of mining area

Arpine Minasyan Minasyan, Hovsep Ghazaryan, Suren Davitavyan, Yeva Bareghamyan et autres

Abstract Background . Long-term residence in mining regions exposes populations to environmental contaminants such as heavy metals and natural geochemical factors, both of which may trigger genotoxic stress and disturb cellular homeostasis. The molecular mechanisms underlying these effects in human populations remain …

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Laser-Driven Utrashort Electron Beams Cause p53-Dependent Alteration of DNA Repair and Cell Death in Non-Small-Cell Lung Cancer Cells

Margarita Pustovalova, Polina Pugacheva, Natalia Vorobyeva, Nelly Babayan et autres

Laser-driven accelerated particle beams have revolutionized the field of cancer treatment by enabling the delivery of extremely high dose-rates of radiation to solid tumors in a matter of femto- to picoseconds. In this study, radiobiological effectiveness of ultrashort pulsed electron beams generated …

Isolation, Characterization, and Anti-Cancer Properties of Microalgal Monogalactosyldiacylglycerol (MGDG)

Baghish Harutyunyan, Anna Zakoyan, Ani Aghabekyan, Angelina Sayadyan et autres

Glycoglycerolipids are amphiphilic compounds found in thylakoid membranes of cyanobacteria, algae, and plants, attracting interest for their therapeutic potential, especially anticancer applications. They interact with biological molecules and show anticancer, antiviral, and anti-inflammatory properties. Among them, monogalactosyldiacylglycerol (MGDG) inhibits cancer cell proliferation …

am (code pays fourni par la source)

Silicone elastomer films loaded with 5-fluorouracil for time-dependent drug release

Mari Atabekyan, Zoya Farmazyan, Nelly Avagyan, Vigen Topuzyan et autres

Silicone elastomer composite films loaded with the antitumor drug 5-fluorouracil (5-FU) were developed for controlled release applications. Polydimethylsiloxane (PDMSOH) films were crosslinked using tetraethoxysilane and room-temperature vulcanization catalysts, with glycerol incorporated as a hydrophilic modifier to regulate permeability of the hydrophobic silicone …

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raw data of generated dose-response curves

Margarita Malakyan, Nelly Babayan, Ruzanna Grigoryan, Natalya Sarkisyan et autres

Schiff bases and their metal-complexes are versatile compounds exhibiting a broad range of biological activities and thus actively used in the drug development process. The aim of the present study was the synthesis and characterization of new Schiff bases and their copper …

Rwanda, am (code pays fourni par la source)

In silico and in vitro evaluation of drug-like properties and anticancer potential of novel 5-fluorouracil derivatives

Kristine Harutyunyan, Л. С. Нерсесова, Violetta Ayvazyan, E. M. Avagyan et autres

The development of more effective and safer anticancer agents remains a critical focus in cancer therapy. While biologics are gaining attention, small molecules continue to play a significant role due to their versatility and cost-effectiveness. This study investigates the potential of synthesized …

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Study of the Anti-Cancer Effect of Glycoglycerolipids Isolated from Microalgae

Baghish Harutyunyan, Anna Zakoyan, Ani Aghabekyan, Angelina Sayadyan et autres

Glycoglycerolipids are amphiphilic compounds found in cyanobacteria, algae, and plants that have attracted significant attention for their therapeutic potential, particularly as anticancer agents. These lipids, primarily located in the thylakoid membranes of chloroplasts, selectively interact with biological molecules, exhibiting anticancer, antiviral, and …

am (code pays fourni par la source)

Consensus Modeling Strategies for Predicting Transthyretin Binding Affinity from Tox24 Challenge Data

Thalita Cirino, L. Masfarre Pinto, Mateusz Iwan, Alexis Dougha et autres

Transthyretin (TTR) is a key transporter of the thyroid hormone thyroxine, and chemicals that bind to TTR, displacing the hormone, can disrupt the endocrine system, even at low concentrations. This study evaluates computational modeling strategies developed during the Tox24 Challenge, using a …

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AI/ML modeling to enhance the capability of in vitro and in vivo tests in predicting human carcinogenicity

Ani Tevosyan, Hrach Yeghiazaryan, Gohar Tadevosyan, Lilit Apresyan et autres

am, de (code pays fourni par la source)

Synthesis, in silico, and in vitro pharmacological evaluation of norbornenylpiperazine derivatives as potential ligands for nuclear hormone receptors

K. S. Badalyan, Nelly Babayan, Natalya Sarkisyan, Ruzanna Grigoryan et autres

Piperazine, norbornene, and their derivatives are valuable scaffolds in rational drug design, with promising therapeutic applications in various diseases, including cancer. Given that hybridization of privileged structures is a highly effective strategy in drug development, we synthesized piperazine derivatives containing a norbornenyl …

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