In silico and in vitro evaluation of drug-like properties and anticancer potential of novel 5-fluorouracil derivatives
Rattachement africain : am, jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The development of more effective and safer anticancer agents remains a critical focus in cancer therapy. While biologics are gaining attention, small molecules continue to play a significant role due to their versatility and cost-effectiveness. This study investigates the potential of synthesized 5-fluorouracil derivatives to improve its drug-like properties, as well as anticancer activity in human lung cancer cells. Among the synthesized compounds, two (2c and 3a) demonstrated greater cytotoxicity and selectivity toward A549 lung cancer cells compared to 5-FU. These derivatives did not induce oxidative stress but instead affected antioxidant enzyme activity, suggesting interference with cellular metabolism. Additionally, these derivatives shifted cells toward hypodiploidy, suggesting the presence of apoptotic cells, while 5-FU significantly increased A549 cell ploidy, a trait linked to cancer progression and treatment resistance. In silico predictions revealed improved pharmacokinetic properties for the 2c derivative and a low probability of hepatotoxicity or neurotoxicity compared to 5-FU. These findings suggest that 2c and 3a derivatives warrant further research as potentially safer and more effective alternatives to 5-FU.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- In silico and in vitro evaluation of drug-like properties and anticancer potential of novel 5-fluorouracil derivatives
- Date Crossref
- 12/11/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Institute of Chemical Physics NAS RA pays non établi dans la noticeStructure de recherche
-
Japan Synchrotron Radiation Research Institute pays non établi dans la noticeStructure de recherche
-
Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry pays non établi dans la noticeStructure de recherche
-
Institute of Molecular Biology NAS of RA pays non établi dans la noticeStructure de recherche
-
CANDLE Synchrotron Research Institute pays non établi dans la noticeStructure de recherche
-
Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS of RA pays non établi dans la noticeInstitution
Institute of Chemical Physics NAS RA, Japan Synchrotron Radiation Research Institute et Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.