Genomic instability and molecular dysregulation in long-term residents of mining area
Rattachement africain : am, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background . Long-term residence in mining regions exposes populations to environmental contaminants such as heavy metals and natural geochemical factors, both of which may trigger genotoxic stress and disturb cellular homeostasis. The molecular mechanisms underlying these effects in human populations remain incompletely understood. This study aimed to investigate genotoxic and oxidative stress responses and their links to gene expression changes and plasma metal concentrations. Methods . Forty-three residents from mining region residents (MRRs) and 39 from non-mining areas were examined. Genotoxicity was evaluated using micronucleus assays in lymphocytes and buccal cells. Mitochondrial DNA copy number (mtDNAcn) was quantified by qPCR, oxidative stress was analysed in erythrocytes and DNA (8-OHdG). Transcriptomic data were integrated with plasma metal levels to identify associations. Results . MRR exhibited higher micronuclei frequency in lymphocytes and reduced mtDNAcn. Micronuclei frequency correlated with plasma manganese and altered CDK10 and JUN expression. mtDNAcn was negatively associated with Mn, positively with Ni, and linked to HSPA1A, IL1A, and TNF expression. Gene-level analyses revealed downregulation of DNA repair genes and upregulation of stress-responsive genes, some of which were associated with both genotoxicity biomarkers and specific metals. Conclusions . Mining-region residency is associated with genomic instability and mitochondrial compromise through dysregulated DNA repair and stress-response genes.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Genomic instability and molecular dysregulation in long-term residents of mining area
- Date Crossref
- 01/07/2026
- Éditeur
- IOP Publishing
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
National Academy of Sciences of Armenia pays non établi dans la noticeOrganisme public
-
California University of Pennsylvania pays non établi dans la noticeUniversité ou école supérieure
-
The Institute of Molecular Biology of the National Academy of Sciences of the Republic of Armenia pays non établi dans la noticeStructure de recherche
-
‘Hydrometeorology and Monitoring Center’ SNCO of the Ministry of Environment of the Republic of Armenia pays non établi dans la noticeOrganisme public
-
CANDLE Synchrotron Research Institute pays non établi dans la noticeStructure de recherche
National Academy of Sciences of Armenia, California University of Pennsylvania et The Institute of Molecular Biology of the National Academy of Sciences of the Republic of Armenia, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.