Sabine Harenkamp

Precision targeting of rhabdomyosarcoma by combining primary CAR NK cells and radiotherapy

Lisa Marie Reindl, Lida Jalili, Tobias Bexte, Sabine Harenkamp et autres

Background: Rhabdomyosarcoma (RMS) is the most common type of soft-tissue sarcoma in children, and it remains a challenging cancer with poor outcomes in high-risk and metastatic patients. This study reports the use of epidermal growth factor receptor (EGFR)-targeted chimeric antigen receptor (CAR) …

de, gb (code pays fourni par la source)

Clonal hematopoiesis landscape in frequent blood donors

Darja Karpova, Hector Huerga Encabo, Elisa Donato, Silvia Calderazzo et autres

ABSTRACT: Donor blood saves lives, yet the potential impact of recurrent large-volume phlebotomy on donor health and hematopoietic stem cells (HSCs) remains largely unexplored. In our study, we conducted a comprehensive screening of 217 older male volunteer donors with a history of …

de, us, gb, es, at (code pays fourni par la source)

CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma

Laura M. Moser, Catrin Heim, Sebastian E. Koschade, Philipp Wendel et autres

Introduction CAR-T cell therapy, though successful in hematologic malignancies, faces challenges in solid tumors due to limitations of autologous T cells. Cytokine-induced killer (CIK) cells can be given safely across allogeneic barriers and constitute alternative effector cells generated from healthy donors. CIK …

de, us (code pays fourni par la source)

Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis

Jochen T. Frueh, Julia Campe, Daniele Yumi Sunaga, Nikita A. Verheyden et autres

Interferon regulatory factor 4 (IRF4) is a master transcription factor that regulates T helper cell (Th) differentiation. It interacts with the Basic leucine zipper transcription factor, ATF-like (BATF), depletion of which in CD4+ T cells abrogates acute graft-versus-host disease (aGVHD)-induced colitis. Here, …

de (code pays fourni par la source)

Sars-Cov-2 Fails to Infect Mesenchymal Stromal Cells (MSCs) - Pre-Clinical Investigations in Support of Therapeutic Use of MSCs for Severe COVID-19

Lisa‐Marie Pfeffermann, Denisa Bojková, Joshua D. Kandler, Sabine Huenecke et autres

de (code pays fourni par la source)

Preanalytic depletion of medicinal anti-CD38 antibody from patient plasma for immunohematology testing

Elisabeth Ehrend, Patricia J. Manns, Sabine Harenkamp, Erhard Seifried et autres

Monoclonal antibodies such as daratumumab that target antigens that are also expressed on red blood cells impede blood group typing. The preferred approach to potential transfusion is to do prior extensive antigen typing of patients' red cells; however, this is not always …

de, us (code pays fourni par la source)

Adaptive Immunity and Pathogenesis of Diabetes: Insights Provided by the α4–Integrin Deficient NOD Mouse

Salim Oulghazi, Sarah K. Wegner, Gabriele Spohn, Nina Müller et autres

BACKGROUND: The spontaneously diabetic "non-obese diabetic" (NOD) mouse is a faithful model of human type-1 diabetes (T1D). METHODS: Given the pivotal role of α4 integrin (CD49d) in other autoimmune diseases, we generated NOD mice with α4-deficient hematopoiesis (NOD.α4-/-) to study the role …

de, us (code pays fourni par la source)

Hematopoietic-Extrinsic Cues Dictate Circadian Redistribution of Mature and Immature Hematopoietic Cells in Blood and Spleen

Miriam Stenzinger, Darja Karpova, Christian Unterrainer, Sabine Harenkamp et autres

Circadian oscillations in circulating leukocyte subsets including immature hematopoietic cells have been appreciated; the origin and nature of these alterations remain elusive. Our analysis of wild-type C57BL/6 mice under constant darkness confirmed circadian fluctuations of circulating leukocytes and clonogenic cells in blood …

de (code pays fourni par la source)

Wave-Complex-Dependent Actin Dynamics Controls Hematopoietic Stem Cell Bone Marrow Retention and Orderly Differentiation into Mature Hematopoietic Lineages

Eliza Wiercinska, David de Gorter, Eva Danner, Sabine Harenkamp et autres

de, se (code pays fourni par la source)

Disturbed immature hematopoiesis in mice with hematopoietic-specific wave complex deficiency

Eliza Wiercinska, David de Gorter, Eva Danner, Sabine Harenkamp et autres

de (code pays fourni par la source)

Knock out of the NADPH oxidase Nox4 has no impact on life span in mice

Flávia Rezende, Christoph Schürmann, Susanne Schütz, Sabine Harenkamp et autres

The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be …

de (code pays fourni par la source)

The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype

Ralf Peter Brandes, Sabine Harenkamp, Christoph Schürmann, Ivana Josipovic et autres

OBJECTIVE: Reactive oxygen species generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases contribute to angiogenesis and vascular repair. NADPH oxidase organizer 1 (NoxO1) is a cytosolic protein facilitating assembly of constitutively active NADPH oxidases. We speculate that NoxO1 also contributes to basal …

de (code pays fourni par la source)