Yuyan Tan

The role of lactylation in breast cancer development: mechanisms, clinical translation and new strategies for treatment

Yanzhen Lu, Xiaoting Yang, Lulu Tan, Yunfei Yang et autres

Worldwide, breast cancer (BC) is a common and deadly illness that poses a serious risk to women's health. Its development is intimately associated with tumor microenvironment (TME) alteration and metabolic problems. Lactic acid, a principal byproduct of glycolysis, not only facilitates the …

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“YiJinJing, Wohu Pushi” Posture‐Voice Therapy for Dysarthria in Parkinson's Disease Patients Following Subthalamic Nucleus Deep Brain Stimulation: A Randomized Controlled Trial

Mei Yang, Xin Sun, Yan Jin, Zhitong Zeng et autres

BACKGROUND: Dysarthria in Parkinson's disease (PD) is difficult to treat, especially post-subthalamic nucleus deep brain stimulation (STN-DBS), as therapies like LSVT show variable efficacy and limited accessibility. "Yi Jin Jing, Wohu Pushi" posture-voice therapy (YJJ-WPVT), emphasizing postural coordination, offers a promising yet …

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Role of necroptosis-related genes in immune activity and prognosis of colorectal cancer

Lulu Tan, Shuaifeng Wang, Weilong Chang, Xiaoying Zhang et autres

Background: Necroptosis plays a critical role in the onset and progression of numerous malignancies, with colorectal cancer (CRC) ranking among the leading causes of cancer-related mortality worldwide. However, the relationship between necroptosis-related genes (NRGs) and CRC remains contentious. Hence, this study aims …

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Cobalt(II)-Catalyzed [4 + 2] Annulation of Indolecarboxamides with Alkenes for Regioselective Synthesis of γ-Carbolinones

Jiawei Li, Yuyan Tan, Yang Han, Jinlei Wang et autres

)-H/N-H bonds in indolecarboxamides with alkenes, facilitated by an 8-aminoquinoline directing group. This reaction represents the first example employing simple olefins as substrates to directly construct the γ-carbolinone motif. Furthermore, it exhibits broad substrate scope and excellent regioselectivity, achieving high yields with …

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Epidural spinal cord stimulation for the management of orthostatic hypotension in Parkinson's disease: A case report

Xue Zhu, Yuyan Tan, Zuxi Gu, Yuchao Yang et autres

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Protecting the intestinal barrier by modulating inflammatory factors to treat intestinal inflammation

Xiang Cheng, Xuefen Lu, Yuyan Tan, Dunkai Shen et autres

The intestinal barrier is one of the body's most important defence barriers, preventing harmful substances in the intestine from crossing the intestinal mucosa into the body. Impaired intestinal barrier function is commonly seen in patients with inflammatory bowel disease (IBD) and is …

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Bacteroides coprocola Protects Dopaminergic Neurons in Rotenone-Induced Parkinson’s disease Mice Model by Modulating Gut Microbiota Dysbiosis and Inhibiting the NLRP3 Signaling Pathway

Yimei Li, Maoxin Huang, Ziluo Chen, Shaokang Yu et autres

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Comparing the efficacy and safety of safinamide with rasagiline in China Parkinson’s disease patients with a matching adjusted indirect comparison

Yuyan Tan, Qianqian Wei, Pingyi Xu, Enxiang Tao et autres

Safinamide and rasagiline are adjuncts to levodopa for the motor fluctuations of Parkinson's Disease (PD). However, there remains a scarcity of head-to-head studies that directly compare safinamide and rasagiline. This study compared safinamide and rasagiline as adjuncts to levodopa in Chinese PD …

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BRAF V600E-mutated lung adenocarcinoma with thyroid metastasis as the initial manifestation: a case report

Yufei Liu, Hanhan Lei, Lingling Cai, Yuyan Tan et autres

Thyroid metastasis of lung adenocarcinoma is exceedingly uncommon. Here we present a case of a 72-year-old Chinese male with hoarseness, dysphagia, pain, and palpable thyroid nodules. Ultrasonography-guided thyroid fine-needle aspiration cytology (FNAC) suggested a high-grade follicular-derived thyroid carcinoma (HGFCTC). Molecular analysis identified …

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Soft X-ray prompt emission from the high-redshift gamma-ray burst EP240315a

Yuan Liu, Hui Sun, D. Xu, D. Svinkin et autres

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Cobalt(II)-Catalyzed C−H Deuteriomethoxylation of Benzamides with CD3OD

Yuyan Tan, Mao‐Gui Huang, Wei Feng, Mengyuan Niu et autres

Herein, we report a practical example of salicylaldehyde-based cobalt-catalyzed C−H deuteriomethoxylation of benzamides using deuterated methanol, facilitated by 8-aminoquinoline as a directing group. The salicylaldehyde-based cobalt catalyst is user-friendly, and the reaction exhibits broad functional group tolerance, accommodating benzene, heterocycles, and naphthalene …

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Comparative Analysis of Static and Dynamic Postural Balance Control in Multiple System Atrophy and Parkinson’s Disease Using an Intermittent Control Model

Wei Bao, Kai Chen, Yuchen Yang, Yuyan Tan et autres