Qianqian Wei

Clinical and genetic characteristics of PLA2G6-related parkinsonism in Southwest China and a comprehensive literature review

Yangfan Cheng, Yang Zhang, Yi Xiao, Shichan Wang et autres

Background Biallelic PLA2G6 mutations are associated with early onset autosomal recessive parkinsonism, exhibiting a broad spectrum of clinical heterogeneity. Objective To comprehensively characterise the clinical, imaging and genetic features of PLA2G6-related parkinsonism. Methods We report 14 new cases of PLA2G6-related parkinsonism in …

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Serum creatinine to cystatin C ratio as monitoring biomarker in Chinese adult spinal muscular atrophy: a prospective cohort study

Sihui Chen, Qiong Wang, Jiajia Fu, Qianqian Wei et autres

BACKGROUND: The creatinine to cystatin C ratio (CCR) can be used as a biomarker of muscle mass and strength, but no studies have evaluated whether it can be used as a biomarker to monitor the efficacy of treatment with nusinersen in Chinese …

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Comparing the efficacy and safety of safinamide with rasagiline in China Parkinson’s disease patients with a matching adjusted indirect comparison

Yuyan Tan, Qianqian Wei, Pingyi Xu, Enxiang Tao et autres

Safinamide and rasagiline are adjuncts to levodopa for the motor fluctuations of Parkinson's Disease (PD). However, there remains a scarcity of head-to-head studies that directly compare safinamide and rasagiline. This study compared safinamide and rasagiline as adjuncts to levodopa in Chinese PD …

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Identification of risk factors and development of a predictive nomogram for sarcopenia in Alzheimer's disease

Sihui Chen, Ruwei Ou, Qianqian Wei, Jiajia Fu et autres

INTRODUCTION: Sarcopenia, with its complex diagnostic process, is a likely independent predictor of poor prognosis in patients with Alzheimer's disease (AD). However, research on the clinical characteristics and biomarkers of AD patients with sarcopenia (ADSA) is limited. METHODS: This study included 180 …

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Comparison of spontaneous brain activity in distinguishing parkinsonian variant of multiple system atrophy from Parkinson’s disease at an early stage

Shichan Wang, Yi Xiao, Yanbing Hou, Chunyu Li et autres

Background The overlapping clinical manifestations in parkinsonian variant of multiple system atrophy (MSA-P) and Parkinson’s Disease (PD) can complicate clinical diagnostic accuracy, particularly in the early stage. The study aims to uncover the patterns of brain function in the initial phase of …

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The potential use of plasma NfL as a diagnostic and prognostic biomarker of fatigue in early Parkinson’s disease

Huifang Shang, Ning-Ning Che, Jingxuan Huang, Shichan Wang et autres

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Amyotrophic lateral sclerosis patients with various gene mutations show diverse motor phenotypes and survival in China

Qirui Jiang, Junyu Lin, Qianqian Wei, Tianmi Yang et autres

Background Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterised by progressive degeneration of motor neurons. Genetic factors have a substantial impact on ALS. Therefore, this study aimed to explore the correlation between genotype (SOD1, TARDBP, FUS, C9orf72) and phenotype in …

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KLF7 promotes adipocyte inflammation and glucose metabolism disorder by activating the PKCζ / NF‐κB pathway

Xin Yang, Maodi Liang, Yihan Tang, Dingling Ma et autres

In the obesity context, inflammatory cytokines secreted by adipocytes lead to insulin resistance and are key to metabolic syndrome development. In our previous study, we found that the transcription factor KLF7 promoted the expression of p-p65 and IL-6 in adipocytes. However, the …

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Ammonium improved cell wall and cell membrane P reutilization and external P uptake in a putrescine and ethylene dependent pathway

Chunquan Zhu, Qianqian Wei, Ya Li Kong, Qing shan Xu et autres

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Unearthing the Alleviatory Mechanisms of Brassinolide in Cold Stress in Rice

Qingshan Xu, Qianqian Wei, Yali Kong, Lianfeng Zhu et autres

Cold stress inhibits rice germination and seedling growth. Brassinolide (BR) plays key roles in plant growth, development, and stress responses. In this study, we explored the underlying mechanisms whereby BR helps alleviate cold stress in rice seedlings. BR application to the growth …

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Unearthing the alleviatory mechanisms of hydrogen sulfide in aluminum toxicity in rice

Chunquan Zhu, Qianqian Wei, Wen Jun Hu, Ya Li Kong et autres

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Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis

Huifang Shang, Qianqian Wei, Yanbing Hou, Lingyu Zhang et autres

The neutrophil-to-lymphocyte ratio (NLR) is considered a robust prognostic biomarker for predicting patient survival outcomes in many diseases. However, it remains unclear whether it can be used as a biomarker for amyotrophic lateral sclerosis (ALS). To correlate NLR with disease progression and …

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