Protecting the intestinal barrier by modulating inflammatory factors to treat intestinal inflammation

Le résumé fourni par la source

The intestinal barrier is one of the body's most important defence barriers, preventing harmful substances in the intestine from crossing the intestinal mucosa into the body. Impaired intestinal barrier function is commonly seen in patients with inflammatory bowel disease (IBD) and is associated with structural and functional abnormalities in the tight junctions of intestinal epithelial cells. Modulating the expression of specific inflammatory factors can effectively reduce intestinal inflammation, promote intestinal barrier repair, and restore intestinal function. This review elucidates the role of modulating inflammatory factors in promoting intestinal barrier restoration and treating intestinal diseases. The effects of regulatory inflammatory factors on cell signaling pathways and gut microbiota were also explored. Technical references are provided for modulating inflammatory factors to restore the intestinal barrier. Finally, the limitations and deficiencies in IBD treatment with intestinal barrier damage and the challenges faced in clinical application are analysed in depth.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.