Airam Nicole Vivanco-Estela

Spontaneously hypertensive rats exhibit reduced facial pain sensitivity with altered electrophysiology and transcriptomics in the trigeminal ganglia

Basak Donertas-Ayaz, Niall P Murphy, Airam Nicole Vivanco-Estela, Matthew R. Sapio et autres

Hypertension has been associated with altered nociceptive thresholds in humans and animal models, but the relationship between blood pressure (BP) and pain sensitivity remains inconsistent. Here, we investigated trigeminal nociception in male spontaneously hypertensive rats (SHRs) compared with normotensive Wistar-Kyoto (WKY) rats …

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CRISPR Epigenome Editing of IL1R1 Expression of Neurons that Innervate the Temporomandibular Joint or Knee Causes Reduced Sensitization to Osteoarthritic Environment

Joshua D. Stover, Robby D. Bowles, Yenisel Cruz-Almeida, Robert M. Caudle et autres

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Identification of sensory fiber types in mouse temporomandibular joint tissues

J Alfaro, E. Wang, Kyle M. Allen, Alejandro J. Almarza et autres

Temporomandibular joint (TMJ) disorders (TMJDs) are linked to heightened nerve sensitivity in TMJ tissues. To set the groundwork for investigating the mechanisms governing this increased responsiveness, this study aimed to identify the types of nerves in the retrodiscal tissue (retrodisc), anterior disc, …

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An operant rodent orofacial nociceptive assay v1

Airam Nicole Vivanco-Estela, Bruna Balbino de Paula, Basak Donertas-Ayaz, Robert M. Caudle

This assay is designed as an efficient method to evaluate nociceptive behaviors and orofacial pain sensitivity in rodents through voluntary facial contact by positive reinforcement using mechanical or thermal stimuli. The protocol includes step-by-step procedures for animal habituation, training, and testing, including …

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Sex-related differences in cannabidiol's antinociceptive efficacy in a trigeminal neuralgia rodent model

Airam Nicole Vivanco-Estela, Sabine Borges da Rocha, Daniela Escobar-Espinal, Gabriela Gonçalves Bálico et autres

ABSTRACT: Trigeminal neuralgia (TN) is a severe orofacial pain condition with sex-specific differences in pain responses. Standard treatments offer limited efficacy and significant side effects. We hypothesized that cannabidiol (CBD) alleviates TN-induced allodynia more effectively than carbamazepine in a sex- and dose-dependent …

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Anti-nociceptive effects of non-antibiotic derivatives of demeclocycline and doxycycline against formalin-induced pain stimulation

Glauce Crivelaro Nascimento, Airam Nicole Vivanco-Estela, Laurent Ferrié, Bruno Figadère et autres

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Cannabidiol and it fluorinate analog PECS-101 reduces hyperalgesia and allodynia in trigeminal neuralgia via TRPV1 receptors

Daniela Maria Escobar-Espinal, Airam Nicole Vivanco-Estela, Núbia Barros, Maurício dos Santos Pereira et autres

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CANNABIDIOL HAS THERAPEUTIC POTENTIAL FOR MYOFASCIAL PAIN IN FEMALE AND MALE PARKINSONIAN RATS

Airam Nicole Vivanco-Estela, Maurício dos Santos Pereira, Francisco Silveira Guimarães, Glauce Crivelaro Nascimento

Musculoskeletal orofacial pain is a complex symptom of Parkinson’s disease (PD) resulting in stomatognathic system dysfunctions aggravated by the disease's rigidity and postural instability. We tested the effect of cannabidiol (CBD), a non-psychotomimetic constituent of Cannabis sativa, in PD-related myofascial pain. All …

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SEX-RELATED DIFFERENCES IN THE ANTINOCICEPTIVE EFFECT OF CANNABIDIOL IN A RODENT MODEL OF TRIGEMINAL NEURALGIA.

Airam Nicole Vivanco-Estela, Francisco Silveira Guimarães, Glauce Crivelaro Nascimento

Trigeminal neuralgia (TN) is a high-intensity, debilitating orofacial pain. As a chronic pain, sex-related differences are relevant factors in behavioral response and pharmacological therapy. We focus on the therapeutic potential of cannabidiol (CBD 3, 10, and 30mg/kg, intraperitoneally for 7-days after lesion …

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BRAINSTEM MODULATES PARKINSONISM-INDUCED OROFACIAL SENSORIMOTOR DYSFUNCTIONS

Daniela Escobar, Gabrielle Jacob, Bruna Araujo Milan, Gabrielli Leal-Luiz et autres

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THE NON-ANTIBIOTIC TETRACYCLINES DDMC AND DDOX REDUCE PAIN-RELATED RESPONSES IN MICE SUBJECTED TO THE FORMALIN TEST

Glauce Crivelaro Nascimento, Airam Nicole Vivanco-Estela, Laurent Ferrié, Bruno Figadère et autres

Previous studies suggested that antibiotic tetracyclines (TC) had interesting analgesic properties (Bastos et al, Eur J Pharmacol, 2007; Ahmed et al, PNAS, 2021). We tested, here, whether such properties could be found in newly synthesized TCs lacking antibiotic activity. Using the formalin-induced …

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Brainstem Modulates Parkinsonism-Induced Orofacial Sensorimotor Dysfunctions

Glauce Crivelaro Nascimento, Gabrielle Jacob, Bruna Araujo Milan, Gabrielli Leal-Luiz et autres

Parkinson's Disease (PD), treated with the dopamine precursor l-3,4-dihydroxyphenylalanine (L-DOPA), displays motor and non-motor orofacial manifestations. We investigated the pathophysiologic mechanisms of the lateral pterygoid muscles (LPMs) and the trigeminal system related to PD-induced orofacial manifestations. A PD rat model was produced …

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