Accès ouvert
2026
article
OpenAlex
Alan de Araujo, Hemaa Sree Kumar, Tao Yang, Emily B. Otmanowski et autres
BACKGROUND: Hypertension is a pervasive global health challenge, impacting more than 1 billion individuals worldwide. Despite strides in therapeutic strategies, a significant proportion of patients remain resistant to the currently available therapies. Although conventional treatments predominantly focus on cardiac, renal, and cerebral …
us, ru
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Accès ouvert
2026
article
OpenAlex
Basak Donertas-Ayaz, Niall P Murphy, Airam Nicole Vivanco-Estela, Matthew R. Sapio et autres
Hypertension has been associated with altered nociceptive thresholds in humans and animal models, but the relationship between blood pressure (BP) and pain sensitivity remains inconsistent. Here, we investigated trigeminal nociception in male spontaneously hypertensive rats (SHRs) compared with normotensive Wistar-Kyoto (WKY) rats …
us
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Accès ouvert
2025
article
OpenAlex
John K. Neubert, Kyle D. Allen, Tamara N. Alliston, Alejandro J. Almarza et autres
Temporomandibular disorders (TMDs) are complex conditions characterized by orofacial pain and dysfunction, affecting a significant portion of the population. TMDs may involve joint and/or muscle pain, dysfunction (e.g., noise, limited or altered jaw movements), or both, leading to a marked decrease in …
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Accès ouvert
2025
preprint
OpenAlex
Airam Nicole Vivanco-Estela, Bruna Balbino de Paula, Basak Donertas-Ayaz, Robert M. Caudle
This assay is designed as an efficient method to evaluate nociceptive behaviors and orofacial pain sensitivity in rodents through voluntary facial contact by positive reinforcement using mechanical or thermal stimuli. The protocol includes step-by-step procedures for animal habituation, training, and testing, including …
us
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Accès ouvert
2023
article
OpenAlex
Basak Donertas-Ayaz, Robert M. Caudle
Trigeminal neuralgia is the most common neuropathic pain involving the craniofacial region. Due to the complex pathophysiology, it is therapeutically difficult to manage. Noradrenaline plays an essential role in the modulation of arousal, attention, cognitive function, stress, and pain. The locus coeruleus, …
us
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2022
article
OpenAlex
Basak Donertas-Ayaz, Ariana C. Brice‐Tutt, Wendi L. Malphurs, Darrice S. Montgomery et autres
Pain has sensory and affective components. Unlike traditional, reflex-based pain assays, operant pain assays can produce more clinically relevant results by addressing the cognitive and motivational aspects of pain in rodents. This paper presents a protocol for assessing mechanical hypersensitivity following chronic …
us
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Accès ouvert
2022
article
OpenAlex
Basak Donertas-Ayaz, Ariana C. Brice‐Tutt, Wendi L. Malphurs, Darrice S. Montgomery et autres
Pain has sensory and affective components. Unlike traditional, reflex-based pain assays, operant pain assays can produce more clinically relevant results by addressing the cognitive and motivational aspects of pain in rodents. This paper presents a protocol for assessing mechanical hypersensitivity following chronic …
us
(code pays fourni par la source)