R. Sky Jones

Clinical Applications of 7 Tesla Magnetic Resonance Imaging for Epilepsy

R. Sky Jones, Zhong Irene Wang, Stephen E. Jones, Chintan Shah

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Cerebral Blood Flow in Children and Adults With Sickle Cell Anemia

Lori C. Jordan, Wesley Richerson, Megan Aumann, Alexander K. Song et autres

BACKGROUND AND OBJECTIVES: Understanding age-related changes in cerebral blood flow (CBF, rate of blood delivery to brain tissue) in sickle cell anemia (SCA) is a prerequisite to incorporating CBF as a marker of brain health. CBF decreases from school-age through adulthood in …

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New/Enlarging T2 Lesions in a Progressive Multiple Sclerosis Trial Cohort: Computer vs Human Detection

Alexandra J. White, R. Sky Jones, Jay Constantini, Douglas L. Arnold et autres

Background: Although detection of new/enlarging multiple sclerosis (MS) lesions is a key metric in clinical practice and research, little is known about how human and automated detection methods compare. We compared findings made by a neuroradiologist to simulate routine practice to those …

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MR Fingerprinting Predicts Gait Improvement After Lumbar Cerebrospinal Fluid Drainage for Normal Pressure Hydrocephalus

R. Sky Jones, Jacqueline Chen, Doksu Moon, Mathias Nittka et autres

ABSTRACT Background Normal pressure hydrocephalus (NPH) results in gait disturbance, but clinical response to extended lumbar drainage (ELD) of cerebrospinal fluid varies. Noninvasive predictors of response are needed. Purpose To determine whether MR fingerprinting (MRF) findings have potential as a quantifiable biomarker …

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Author Response: Distribution of Silent Cerebral Infarcts in Adults With Sickle Cell Disease

Lori C. Jordan, R. Sky Jones, Michael R. DeBaun, Andria L. Ford

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Cerebral vascular shunting and oxygen metabolism in sickle cell disease

Alexander K. Song, Wesley Richerson, Megan Aumann, Spencer Waddle et autres

ABSTRACT: Patients with sickle cell disease (SCD) are at elevated risk of silent cerebral infarcts and strokes; however, they frequently lack established stroke risk factors (eg, macrovascular arterial steno-occlusion) and the mechanisms underlying such events are incompletely characterized. This study evaluated cerebral …

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In vivo CEST-Dixon MRI in axillary lymph nodes with and without carcinoma: potential for noninvasive determination of lymph node metastasis

Rachelle Crescenzi, Paula M. C. Donahue, R. Sky Jones, Chelsea Lee et autres

The overall goal of this work is to apply a CEST-Dixon MRI approach in the axillary lymph nodes (LNs) of women with breast cancer to test fundamental hypotheses about biochemical LN profiles with carcinoma. Mean z-spectra and corresponding significant differences in cohorts …

Distribution of Silent Cerebral Infarcts in Adults With Sickle Cell Disease

R. Sky Jones, Andria L. Ford, Manus J. Donahue, Slim Fellah et autres

BACKGROUND AND OBJECTIVES: Previously we demonstrated that 90% of infarcts in children with sickle cell anemia occur in the border zone regions of cerebral blood flow (CBF). We tested the hypothesis that adults with sickle cell disease (SCD) have silent cerebral infarcts …

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In vivo lymph node CEST‐Dixon MRI in breast cancer patients with metastatic lymph node involvement

Manus J. Donahue, Paula M. C. Donahue, R. Sky Jones, Maria Garza et autres

Abstract Purpose Axillary lymph nodes (LNs) often present a reservoir for metastatic breast cancer, yet metastatic LN involvement cannot be discerned definitively using diagnostic imaging. This study investigated whether in vivo CEST may discriminate LNs with versus without metastatic involvement. Methods 3T …

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Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children

Leon Y. Cai, Costin Tanase, Adam W. Anderson, Nikita Patel et autres

BACKGROUND AND PURPOSE: Type 1 diabetes affects over 200,000 children in the United States and is associated with an increased risk of cognitive dysfunction. Prior single-site, single-voxel MRS case reports and studies have identified associations between reduced NAA/Cr, a marker of neuroaxonal …

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Silent infarction in sickle cell disease is associated with brain volume loss in excess of infarct volume

R. Sky Jones, Manus J. Donahue, L. Taylor Davis, Sumit Pruthi et autres

Introduction Sickle cell disease (SCD) increases cerebral infarct risk, but reported effects on brain volume have varied. More detailed information using larger cohorts and contemporary methods could motivate the use of longitudinal brain volume assessment in SCD as an automated marker of …

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Canopy classification using LiDAR: a generalizable machine learning approach

R. Sky Jones, Racha Elkadiri, Henrique G. Momm

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