Maria Garza

Neurofluid circulation changes during a focused attention style of mindfulness meditation

Bryce A. Keating, David R. Vago, Kilian Hett, Ciaran Considine et autres

Neurofluids, including cerebrospinal fluid (CSF) and interstitial fluid, circulate through regulated central nervous system pathways to clear cerebral waste and support brain health, with elevated CSF flow hyperdynamicity and regurgitation through the cerebral aqueduct associating with aging and neurodegeneration. Sleep exerts state-dependent …

us (code pays fourni par la source)

The reactivity penumbra as a novel metric of ischemic symptomatology in patients with intracranial cerebrovascular disease

Caleb Han, Wesley Richerson, Maria Garza, Melanie Leguizamon et autres

Motivation: Quantitation of cerebrovascular reactivity (CVR) impairment from hypercapnic MRI stimuli is complicated by differences in imaging parameters, stimuli, and vendors. Goal(s): To evaluate if the volume of CVR impairment represents a reactivity penumbra that correlates directly with recent ischemic symptoms. Approach: …

The Choroid Plexus Water Density in Humans Assessed from High-Spatial Resolution Proton Density MRI: Normative Values and Effect of Time of Day

Maeve Curtin, Alexander Song, Melanie Leguizamon, Maria Garza et autres

Motivation: Choroid plexus (ChP) function reflects important processes of the neurofluid circuit, but quantification of perfusion and other parameters requires quantitative knowledge of water density. Goal(s): To quantify ChP water density at high spatial resolution over the course of a day. Approach: …

An MRI investigation of the diurnal relationship between cerebral hemo-metabolic activity and bulk cerebrospinal fluid flux

Maeve Curtin, Melanie Leguizamon, Alexander Song, Kilian Hett et autres

Motivation: An improved understanding of how endogenous cerebral hemo-metabolic activity regulates neurofluid circulation and its relevance to understanding mechanisms of peptide retention and the sequelae of neurodegenerative proteinopathies. Goal(s): To investigate diurnal changes in perfusion and oxygen extraction fraction (OEF), and relate …

Diurnal regulation of cerebrospinal fluid flow dynamics assessed using cardiac-corrected phase-contrast magnetic resonance imaging

Melanie Leguizamon, Kilian Hett, Maeve Curtin, Alexander Song et autres

Motivation: Circadian regulation of cerebrospinal fluid (CSF) flow dynamics during wakefulness is incompletely understood yet has relevance to the growing number of studies of neurofluid circulation dysfunction. Goal(s): To investigate repeated changes in CSF flow kinetics through the cerebral aqueduct over the …

A Deep Learning MRI Investigation of Choroid Plexus Hypertrophy and Alzheimer’s Disease Proteinopathy

Kilian Hett, Alexander Song, Melanie Leguizamon, Maeve Curtin et autres

Motivation: To apply a deep learning MRI architecture investigating the role of ChP hypertrophy on cerebral proteinopathy and clinical progression in Alzheimer's Disease. Goal(s): To compare ChP volumes with cerebral protein retention and relevance to clinical progression. Approach: A fully convolutional neural …

Cerebrovascular Reactivity Response Times Following Revascularization Surgery in Patients with Moyamoya

Wesley Richerson, Alex A. Bhogal, Caleb Han, Maria Garza et autres

Motivation: Blood-oxygenation-level-dependent cerebrovascular reactivity (BOLD-CVR) is increasingly used to assay impairment in moyamoya disease, however BOLD-CVR response to surgery has not been fully characterized with a fixed inspiration stimulus. Goal(s): To fully characterize the temporal BOLD-CVR response to revascularization surgery in MMD …

3-Tesla Parasagittal dural space (PSD) T2 relates to PSD volume and correlates with diurnal circadian oscillation during wakefulness

Kilian Hett, Melanie Leguizamon, Colin McKnight, Alexander Song et autres

Motivation: The parasagittal dural space (PSD) has been shown to harbor meningeal lymphatic vessels and is hypothesized to play a fundamental role in CSF egress and neuroimmune functions. While PSD hypertrophy has been demonstrated with age and neurodegeneration, limited information is available …

Noninvasive MR Lymphangiography for assessing lymph fluid congestion in human lymphedema

Megan Aumann, Shannon Stark Taylor, Vanessa Crain, Maria Garza et autres

Motivation: Lymphedema is a chronic progressive disease with no curative therapies. MR lymphangiography has potential to detect lymphatic congestion and characterize fundamental properties of lymphatic fluid flow noninvasively to inform therapeutic strategies. Goal(s): Utilize non-invasive MR lymphangiography (MRL) to assess lymphatic fluid …

Neurofluid circulation changes during a focused attention style of mindfulness meditation

Bryce A. Keating, David R. Vago, Kilian Hett, Ciaran Considine et autres

Abstract Neurofluids, including cerebrospinal fluid (CSF) and interstitial fluid, circulate through regulated central nervous system pathways to clear cerebral waste and support brain health, with elevated CSF flow hyperdynamicity and regurgitation through the cerebral aqueduct associating with aging and neurodegeneration. Sleep exerts …

nl, us (code pays fourni par la source)

The choroid plexus water density

Maeve Curtin, Kilian Hett, Melanie Leguizamon, Alexander K. Song et autres

PURPOSE: To quantify normative ranges and circadian variability of the choroid plexus (ChP) water density in healthy adults. METHODS: Actigraphy assessments of circadian activity were performed for 5 days in healthy participants (n = 15; age = 28.5 ± 6.5 years) and …

us (code pays fourni par la source)

The influence of computer-controlled Motorbunny™ device use on sexual health and sleep behaviors

Manus J. Donahue, Maria Garza, Ciaran Considine

Abstract Sleep has gained much attention as a marker of cerebral health, and it is now well-established that sleep becomes disrupted in normal aging and in the setting of neurodegeneration. However, it remains less clear how sleep behaviors can be modified by …

us (code pays fourni par la source)