Cerebral Blood Flow in Children and Adults With Sickle Cell Anemia
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Le résumé fourni par la source
BACKGROUND AND OBJECTIVES: Understanding age-related changes in cerebral blood flow (CBF, rate of blood delivery to brain tissue) in sickle cell anemia (SCA) is a prerequisite to incorporating CBF as a marker of brain health. CBF decreases from school-age through adulthood in nonanemic people. In SCA, CBF is generally increased to compensate for anemia, but knowledge of age-related norms is limited. We hypothesized that age-related CBF trajectories differ for SCA vs nonanemic healthy persons: CBF increases from childhood to early adulthood in SCA to compensate for reduced blood oxygen content and then plateaus because of reduced vasodilatory capacity with older age. METHODS: ) related to CBF. RESULTS: = 96.5%, IQR = 95%-98.2%). Regression analyses, including an interaction between age and group (SCA vs control), showed that CBF increases in SCA by 5.03 mL/100 g/min per decade (95% CI 1.70-8.37) and plateaus at approximately age 30-35 years. In controls, CBF decreased by -5.20 mL/100 g/min per decade (95% CI -8.96 to -1.94). DISCUSSION: The divergent age dependency of CBF between SCA and non-anemic persons may be explained by a gradient of increasing CBF with age required to compensate for reductions in blood oxygen content in SCA, with possible exhaustion of cerebral vasodilatory abilities in the fourth decade of life. Longitudinal studies are needed.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cerebral Blood Flow in Children and Adults With Sickle Cell Anemia
- Date Crossref
- 11/11/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Vanderbilt University Medical Center Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Mayo Clinic in Arizona Department of Radiology pays non établi dans la noticeÉtablissement de santé
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Athinoula A. Martinos Center for Biomedical Imaging pays non établi dans la noticeStructure de recherche
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Massachusetts General Hospital Department of Radiology pays non établi dans la noticeÉtablissement de santé
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Rodeghier Consulting pays non établi dans la noticeInstitution
Department of Pediatrics — Vanderbilt University Medical Center, Department of Radiology — Mayo Clinic in Arizona et Athinoula A. Martinos Center for Biomedical Imaging, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.