Accès ouvert
2026
article
OpenAlex
Keiko Yasuda, Junichi Aoki, Kotaro Tanaka, Shintaro Shichinohe et autres
The innate immune response to viral infection needs to be tightly regulated to ensure effective pathogen clearance while avoiding excessive immune activation. During SARS-CoV-2 infection, however, the immune system often fails to elicit appropriate responses, resulting in cytokine-release syndrome in patients with …
jp
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2026
article
OpenAlex
Victoria Simanihuruk, Yurie Kida, K. Takada, Harumi Yamaguma et autres
) values and favorable selectivity indices. GBF1-targeting ASOs thus represent a promising host-directed antiviral approach for controlling respiratory RNA viruses.
jp
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2026
article
OpenAlex
Nao Gojo, Yu Usami, Katsutoshi Hirose, Satoru Toyosawa et autres
The nose and mouth are the primary entry points for upper respiratory severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, the influence of different entry routes on viral spread remains unclear. Oral and nasal infection routes in terms of viral distribution …
jp
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Accès ouvert
2025
article
OpenAlex
Nantaporn Kaewaroon, S Yoshimoto, Luthfi Muawan, Shintaro Shichinohe et autres
Influenza A and B viruses cause annual epidemics and continue to pose global public health concerns. The most effective approach to preventing or mitigating the severity of influenza is vaccination. Inactivated split influenza HA vaccines are commonly used worldwide due to their …
th, jp
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2025
article
OpenAlex
Shintaro Shichinohe, Takahiro Hiono, Yasushi Itoh, K. Takada et autres
ABSTRACT H5N1 high pathogenicity avian influenza virus (HPAIV) has spread in wild birds and poultry worldwide. H5N1 HPAIV belonging to the currently predominant clade 2.3.4.4b has infected not only birds but also mammals (wild and domestic animals), with several human infections also …
jp, kh
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2025
preprint
OpenAlex
Shintaro Shichinohe, Hikaru Sugimoto, Masako Yamasaki, Rina Hashimoto et autres
Summary The H5N1 high pathogenicity avian influenza virus (HPAIV) of clade 2.3.4.4b, which spreads globally via wild birds, has become a major public health concern because it can infect a variety of mammals, including humans. In 2024, infection of dairy cattle with …
jp, vn
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2025
article
OpenAlex
Atsushi Kawai, Taro Shimizu, Hiroki Tanaka, Shintaro Shichinohe et autres
Kawai A., Shimizu T., Tanaka H., et al. Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 influenza virus with reduced adverse reactions. Molecular Therapy 33, 529 (2025); https://doi.org/10.1016/j.ymthe.2024.12.032.
jp, vn
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2024
article
OpenAlex
Atsushi Kawai, Taro Shimizu, Hiroki Tanaka, Shintaro Shichinohe et autres
Messenger RNA vaccines based on lipid nanoparticles (mRNA-LNPs) are promising vaccine modalities. However, mRNA-LNP vaccines frequently cause adverse reactions such as swelling and fever in humans, partly due to the inflammatory nature of LNP. Modification of the ionizable lipids used in LNPs …
jp, vn
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2024
article
OpenAlex
Itsuki Anzai, Junso Fujita, Chikako Ono, Y Kosaka et autres
ABSTRACT Although the global crisis caused by the coronavirus disease 2019 (COVID-19) pandemic is over, the global epidemic of the disease continues. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, initiates infection via the binding of the receptor-binding domain (RBD) …
jp
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2024
article
OpenAlex
Yohei Kurosaki, Ken‐Ichi Hanaki, Shuetsu Fukushi, Masayuki Shimojima et autres
Biosafety Level 4 facilities have been established in our country to promote research and development and national capacity of diagnostic test systems for infectious diseases, including highly pathogenic viruses. In particular, the operation of a suit-type laboratory requiring positive pressure protective suits …
jp
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2023
article
OpenAlex
Shintaro Shichinohe, Tokiko Watanabe
The numerous influenza infections that occur every year present a major public health problem. Influenza vaccines are important for the prevention of the disease; however, their effectiveness against infection can be suboptimal. Particularly in the elderly, immune induction can be insufficient, and …
jp
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Accès ouvert
2023
article
OpenAlex
K. Takada, Mahoko Takahashi Ueda, Shintaro Shichinohe, Yurie Kida et autres
Coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), encode a proofreading exonuclease, nonstructural protein 14 (nsp14), that helps ensure replication competence at a low evolutionary rate compared with other RNA viruses. In the current pandemic, SARS-CoV-2 has accumulated diverse genomic mutations …
jp
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