Itsuki Anzai

A divergent betacoronavirus with a functional furin cleavage site in South American bats

K. Takada, Nicholas Yamahoki, Jonathon C. O. Mifsud, Itsuki Anzai et autres

Abstract Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus , including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome virus (MERS-CoV), have attracted particular attention due to their recent zoonotic …

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iEvac-Z, an Inactivated Ebola Vaccine — Phase 1 Study in Japan

Tokiko Watanabe, Michiko Koga, Masanori Nojima, Minako Kono et autres

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Senescence-like cells recruit γδ T cells to drive prolonged hyposmia after SARS-CoV-2 infection in mice

Shunya Tsuji, Sosuke Nakano, Koyu Ito, Shohei Minami et autres

Persistent hyposmia is a hallmark of post COVID-19 conditions, yet the mechanisms sustaining olfactory dysfunction after viral clearance remain poorly understood. Here, using mouse models of SARS-CoV-2 infection, we show that virus-induced senescence-like changes in uninfected olfactory mucosal fibroblasts persist long after …

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Broad-spectrum antiviral activity of antisense oligonucleotides targeting GBF1 against SARS-CoV-2 and influenza viruses

Victoria Simanihuruk, Yurie Kida, K. Takada, Harumi Yamaguma et autres

) values and favorable selectivity indices. GBF1-targeting ASOs thus represent a promising host-directed antiviral approach for controlling respiratory RNA viruses.

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Innenrücktitelbild: Synthesis of Low‐Molecular‐Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS‐CoV‐2 Infection (Angew. Chem. 6/2025)

Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba et autres

A newly designed and synthesized low-molecular-weight fucoidan analogue was found to inhibit not only heparanase activity but also infection by the SARS-CoV-2 Wuhan strain and two Omicron subvariants, BA.2 and BA.5, as reported by Kazunobu Toshima, Daisuke Takahashi, and co-workers in their …

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Inside Back Cover: Synthesis of Low‐Molecular‐Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS‐CoV‐2 Infection (Angew. Chem. Int. Ed. 6/2025)

Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba et autres

A newly designed and synthesized low-molecular-weight fucoidan analogue was found to inhibit not only heparanase activity but also infection by the SARS-CoV-2 Wuhan strain and two Omicron subvariants, BA.2 and BA.5, as reported by Kazunobu Toshima, Daisuke Takahashi, and co-workers in their …

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Synthesis of Low‐Molecular‐Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS‐CoV‐2 Infection

Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba et autres

Heparan sulfate (HS) is ubiquitous on cell surfaces and is used as a receptor by many viruses including SARS-CoV-2. However, increased activity of the inflammatory enzyme heparanase (HPSE), which hydrolyses HS, in patients with COVID-19 not only increases the severity of symptoms …

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Synthesis of Low‐Molecular‐Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS‐CoV‐2 Infection

Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba et autres

Abstract Heparan sulfate (HS) is ubiquitous on cell surfaces and is used as a receptor by many viruses including SARS‐CoV‐2. However, increased activity of the inflammatory enzyme heparanase (HPSE), which hydrolyses HS, in patients with COVID‐19 not only increases the severity of …

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Characterization of a neutralizing antibody that recognizes a loop region adjacent to the receptor-binding interface of the SARS-CoV-2 spike receptor-binding domain

Itsuki Anzai, Junso Fujita, Chikako Ono, Y Kosaka et autres

ABSTRACT Although the global crisis caused by the coronavirus disease 2019 (COVID-19) pandemic is over, the global epidemic of the disease continues. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, initiates infection via the binding of the receptor-binding domain (RBD) …

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Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation

Rahmi dianty, Junki Hirano, Itsuki Anzai, Yuta Kanai et autres

It is essential to employ efficient measures to prevent the transmission of pathogenic agents during a pandemic. One such method involves using hypochlorous acid (HClO) solution. The oxidative properties of HClO water (HAW) can contribute to its ability to eliminate viral particles. …

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Epoxidized graphene grid for highly efficient high-resolution cryoEM structural analysis

Junso Fujita, Fumiaki Makino, Haruyasu Asahara, Maiko Moriguchi et autres

Abstract Functionalization of graphene is one of the most important fundamental technologies in a wide variety of fields including industry and biochemistry. We have successfully achieved a novel oxidative modification of graphene using photoactivated ClO 2 · as a mild oxidant and …

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Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein

Ryota Otsubo, Takeharu Minamitani, Kouji Kobiyama, Junso Fujita et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Variants of concern (VOCs) such as Delta and Omicron have developed, which continue to spread the pandemic. It has been reported that these VOCs reduce vaccine efficacy and evade many …

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