Gemma Serra‐Bardenys

LOXL 2‐mediated chromatin compaction is required to maintain the oncogenic properties of triple‐negative breast cancer cells

Gemma Serra‐Bardenys, Enrique Blanco, Carmen Escudero‐Iriarte, Queralt Serra‐Camprubí et autres

Oxidation of histone H3 at lysine 4 (H3K4ox) is catalyzed by lysyl oxidase homolog 2 (LOXL2). This histone modification is enriched in heterochromatin in triple-negative breast cancer (TNBC) cells and has been linked to the maintenance of compacted chromatin. However, the molecular …

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Author response for " LOXL 2‐mediated chromatin compaction is required to maintain the oncogenic properties of triple‐negative breast cancer cells"

Gemma Serra‐Bardenys, Enrique Blanco, Carmen Escudero‐Iriarte, Queralt Serra‐Camprubí et autres

Author response for " LOXL 2‐mediated chromatin compaction is required to maintain the oncogenic properties of triple‐negative breast cancer cells"

Gemma Serra‐Bardenys, Enrique Blanco, Carmen Escudero‐Iriarte, Queralt Serra‐Camprubí et autres

Enzymatic lysine oxidation as a posttranslational modification

Gemma Serra‐Bardenys, Sandra Peiró

Oxidoreductases catalyze oxidation-reduction reactions and comprise a very large and diverse group of enzymes, which can be subclassified depending on the catalytic mechanisms of the enzymes. One of the most prominent oxidative modifications in proteins is carbonylation, which involves the formation of …

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Maintaining oxidized H3 in heterochromatin is required for the oncogenic capacity of triple-negative breast cancer cells

Gemma Serra‐Bardenys, Tian V. Tian, Enrique Blanco, Jessica Querol et autres

SUMMARY The histone modification of H3 oxidized at lysine 4 (H3K4ox) is catalyzed by lysyl oxidase–like 2 (LOXL2) and is enriched in heterochromatin in triple-negative breast cancer (TNBC) cells. Although H3K4ox has been linked to the maintenance of compacted chromatin, the molecular …

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LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells

Joan Pau Cebrià‐Costa, Laura Pascual‐Reguant, Abel González-Pérez, Gemma Serra‐Bardenys et autres

Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) cell lines and patient-derived xenografts (PDXs) than those …

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Reduction of LOXL2-mediated H3K4 oxidation increases chromatin accessibility and promotes chemosensitivity of triple-negative breast cancer cells

Joan Pau Cebrià‐Costa, Laura Pascual‐Reguant, Abel González-Pérez, Gemma Serra‐Bardenys et autres

Abstract Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase–like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) cell lines and patient–derived xenographs (PDXs) than …

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Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains

Laura Pascual‐Reguant, Enrique Blanco, Silvia Galan, François Le Dily et autres

Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, with a yet unknown function. Here we map the …

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Lysine-Specific Histone Demethylases Contribute to Cellular Differentiation and Carcinogenesis

Gaetano Verde, Jessica Querol-Paños, Joan Pau Cebrià‐Costa, Laura Pascual‐Reguant et autres

Histone modifications regulate chromatin structure, gene transcription, and other nuclear processes. Among the histone modifications, methylation has been considered to be a stable, irreversible process due to the slow turnover of methyl groups in chromatin. However, the discovery of three different classes …

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