Shiyu Deng

IFN ‐ γ ‐Responsive Microglia‐Derived Extracellular Vesicles Impair White Matter Repair After Stroke Through a miR ‐9‐5p/ NEDD4 ‐Dependent Mechanism

Dongliang Qian, Tongtong Xu, Y Guo, Shiyu Deng et autres

ABSTRACT Promoting white matter repair is crucial for functional recovery after ischemic stroke. Our previous study has identified an IFN‐ γ ‐responsive microglia phenotype in the brain after stroke. However, its role in white matter repair remains poorly understood. Herein, we find …

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Photocured Biomimetic Microtextured Hydrogels for Rewritable and Physically Unclonable Anti-counterfeiting Labels

Jinyue Xie, Shiyu Deng, Fei Liang, Huan Tang et autres

With growing demand for secure information storage and authentication, integrating static physical fingerprints with dynamic rewritable information within a single carrier remains a challenge. This study proposes a multilevel anti-counterfeiting strategy based on biomimetic microtextured polymer hydrogels (MTPHs). Soft replication of feather-derived …

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高海况两相流下S弯进气道多目标优化设计

李鑫, 刘晶, Zhou Li, Shiyu Deng et autres

针对高海况环境下掠海飞行器进气系统性能提升需求,开展了气液两相流条件下S弯进气道的多目标优化设计研究。首先,基于超椭圆截面参数化方法,构建了包含7个关键设计变量的S弯进气道模型;其次,采用最优拉丁超立方实验设计结合敏感性分析,揭示了设计参数间存在的显著非线性与交互耦合效应,其中截面超椭圆变化指数的二阶影响尤为突出。在此基础之上,结合Kriging代理模型与NSGA-Ⅱ算法,建立了高效的多目标优化设计流程,实现了总压恢复系数最大化与畸变指数最小化之间的平衡。结果显示:与基准进气道相比,优化进气道总压恢复系数提升至0.994(相对增幅0.71%),畸变指数降低24.6%;在5%~20%吞水量范围内,优化进气道展现出良好的性能鲁棒性。

Emergent Polar Metal Phase in a Van der Waals Mott Magnet

Shiyu Deng, Matthew J. Coak, Charles R. S. Haines, Hayrullo Hamidov et autres

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Interferon‐γ–Responsive Microglia‐Derived Extracellular Vesicles Inhibited Neurogenesis After Stroke via MicroRNA‐199a‐5p/ SIRT1 Axis

Tongtong Xu, Dongliang Qian, Shiyu Deng, Yiyan Guo et autres

Background Previous studies have reported the presence of interferon‐responsive microglia in the brain after central nervous system injury. However, their roles and the underlying mechanisms in neurological function recovery remain poorly understood. Methods Adult male mice were subjected to 90‐minute transient middle …

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BaFe 2 Se 3 : A quasiunidimensional noncentrosymmetric superconductor

Shiyu Deng, Aye Roll, W. G. Zheng, Geetanjali Giri et autres

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Single-Cell RNA Sequencing Characterizes Microglial Phenotypic Heterogeneity Across Different Stroke Subtypes

Yiyan Guo, Tongtong Xu, Chang Liu, Shiyu Deng et autres

Microglia-mediated neuroinflammation is a key contributor to secondary brain injury across diverse cerebrovascular pathologies, yet the precise transcriptomic diversity and temporal evolution of microglial states across different stroke subtypes remain to be fully elucidated. We utilized single-cell RNA sequencing to profile the …

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Lipid Nanoparticle-Mediated Targeted Delivery of MEGF10 siRNA to Astrocytes Reduced Synaptic Phagocytosis and Promoted Stroke Recovery in Mice

Tongtong Xu, Yan Chang, Jingjing Xu, Dongliang Qian et autres

Astrocyte-mediated synaptic phagocytosis plays a critical role in regulating brain development and disease progression. Our previous studies have demonstrated that MEGF10, a key molecule mediating astrocytic phagocytosis of synapses, is remarkably upregulated during the chronic phase of stroke, leading to synapse loss …

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Uncovering Analytical Patterns for Hazardous Components in Agricultural Production Systems

Shiyu Deng, Xinxin Wu, Yongqiang Shi, Hany S. El‐Mesery et autres

Global food safety concerns underscore the critical importance of detecting hazardous components in agricultural production. This systematic review uncovers the prevalence and health impacts of common hazardous agents in agricultural commodities, including pesticide residues, heavy metals, mycotoxins, microbial contaminants, antibiotic residues, and …

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Dual‐Functionalized Extracellular Vesicles Promote Brain Repair and Remodeling Following Ischemic Stroke in Mice

Victoria Shi, Shengju Wu, Qianyuan Lian, Rubing Shi et autres

BACKGROUND: Ischemic stroke remains a leading cause of long-term disability and mortality worldwide, with few effective treatment options. A key challenge in recovery is the brain's limited capacity to regenerate neurovascular structures after injury. To address this, we developed a dual-functionalized extracellular …

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Multilevel Intelligent Anti‐Counterfeiting Label with Spatially Selective Dynamic Aurora Response and 3D Mesoscopic Physical Unclonable Function Fingerprint

Yan Li, Shiyu Deng, Yang Li, Huan Tang et autres

Abstract With the increasing demand for anti‐counterfeiting measures, the efficient integration of multi‐level optical anti‐counterfeiting information has become a critical challenge. In this study, a novel bottom‐up self‐assembly technique is introduced for fabricating composite integrated films. This method overcomes the size limitations …

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Dome-like pressure-temperature phase diagram of the cooperative Jahn–Teller distortion in NaNiO2

Liam A. V. Nagle‐Cocco, James Mark Alexander Steele, Shiyu Deng, Xiaotian Zhang et autres

Abstract NaNiO2 is a Ni3+-containing layered material consisting of alternating triangular networks of Ni and Na cations, separated by octahedrally-coordinated O anions. At ambient pressure, it features a collinear Jahn–Teller distortion below T onset JT ≈ 480 K, which disappears in a …

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