Kate L. Kruczynski

Livestock production intensity and mucosal IgA and IgG responses to H5N1 highly pathogenic avian influenza A virus, North Carolina, 2021-2022

Nora Pisanic, Kathleen M. Kurowski, Timothy Carter, Bonita Salmerón et autres

Abstract Background Direct livestock exposure is a risk factor for zoonotic influenza, including H5N1 highly pathogenic avian influenza (HPAI) A virus. But whether living in regions of high poultry and swine production intensity (PPI, SPI) increases risk of exposure to zoonotic influenza …

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High in vitro activity of aztreonam/avibactam against NDM-producing Enterobacterales with emerging resistance in Escherichia coli in the United States Mid-Atlantic region

Eetu Eklund, Tyler Maruca, Kate L. Kruczynski, Heather Critchfield et autres

ABSTRACT New Delhi metallo-β-lactamase (NDM)-producing Enterobacterales represent a critical antimicrobial resistance threat with limited therapeutic options. Aztreonam/avibactam, which combines the stability of aztreonam against metallo-β-lactamases with the inhibition of serine β-lactamases by avibactam, is a promising therapeutic candidate. However, emerging resistance associated …

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Roles of children, isolation measures and socioeconomic status in SARS-CoV-2 household transmission: a retrospective cohort study in a southern US city

Jessica K. Fairley, Serena S Leung, Brianna A Binion, Kacy D Nowak et autres

Objective: There has been significant debate about both the role of children in SARS-CoV-2 community transmission as well as the potential harm or lack thereof of the virus in the paediatric population. We aimed to better understand how children are impacted by …

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Development of an enteric pathogen multiplex immunoassay to measure antibody responses in blood and saliva for integrated serology applications

Lindsay N. Avolio, Nora Pisanic, Kate L. Kruczynski, William John Moss et autres

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Swine production intensity and swine-specific fecal contamination of household surfaces at residences of industrial livestock operation workers and community residents, North Carolina, USA

Kathleen Mary Kurowski, Nora Pisanic, Kristoffer Spicer, Kate L. Kruczynski et autres

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The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization

Joshua L. Kennedy, Frances Eun-Hyung Lee, Troy J. Kemp, Lígia A. Pinto et autres

In October 2020, the National Cancer Institute (NCI) Serological Sciences Network (SeroNet) was established to study the immune response to COVID-19, and "to develop, validate, improve, and implement serological testing and associated technologies" (https://www.cancer.gov/research/key-initiatives/covid-19/coronavirus-research-initiatives/serological-sciences-network). SeroNet is comprised of 25 participating research institutions …

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Inter-laboratory harmonization of microsphere immunoassays for SARS-CoV-2 antibody detection in contrived dried blood spots and oral fluids

Kate L. DeRosa, Nora Pisanic, Kate L. Kruczynski, Christopher D. Heaney et autres

ABSTRACT Dried blood spots (DBS) and oral fluids (OF) are easily attainable biospecimen types that enabled population-scale antibody monitoring for SARS-CoV-2 exposure and vaccination. However, the degree to which the two different biospecimen types can be used interchangeably remains unclear. To address …

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Application of machine learning algorithms to identify serological predictors of COVID-19 severity and outcomes

Santosh Dhakal, Anna Yin, Marta Escarra‐Senmarti, Zoe O Demko et autres

BACKGROUND: Critically ill hospitalized patients with COVID-19 have greater antibody titers than those with mild to moderate illness, but their association with recovery or death from COVID-19 has not been characterized. METHODS: In a cohort study of 178 COVID-19 patients, 73 non-hospitalized …

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High SARS-CoV-2 secondary infection rates in households with children in Georgia, United States, Fall 2020—Winter 2021

Kai Nowak, Morgan A. Lane, Armand Mbanya, Jasmine Carter et autres

Background A wide range of household secondary infection rates has been reported, and the role of children in population transmission dynamics for SARS-CoV-2 remains ill-defined. We sought to better understand household infection early in the pandemic. Methodology A cross-sectional study of 17 …

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Inter-laboratory harmonization of microsphere immunoassays for SARS-CoV-2 antibody detection in dried blood spots and oral fluids

Kate L. DeRosa, Nora Pisanic, Kate L. Kruczynski, Christopher D. Heaney et autres

Dried blood spots (DBS) and oral fluids (OF) are easily attainable biospecimen types that have enabled population scale antibody monitoring for SARS-CoV-2 exposure and vaccination. However, the degree to which the two different biospecimen types can be used interchangeably remains unclear. To …

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Early, Robust Mucosal Secretory Immunoglobulin A but not Immunoglobulin G Response to Severe Acute Respiratory Syndrome Coronavirus 2 Spike in Oral Fluid Is Associated With Faster Viral Clearance and Coronavirus Disease 2019 Symptom Resolution

Nora Pisanic, Annukka A.R. Antar, Marissa K. Hetrich, Zoe O Demko et autres

BACKGROUND: Efforts are underway to support the development of novel mucosal coronavirus disease 2019 (COVID-19) vaccines. However, there is limited consensus about the complementary role of mucosal immunity in disease progression and how to evaluate immunogenicity of mucosal vaccines. This study investigated …

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SARS-CoV-2 antibody prevalence by industry, workplace characteristics, and workplace infection prevention and control measures, North Carolina, USA, 2021 to 2022

Carolyn Gigot, Nora Pisanic, Kristoffer Spicer, Meghan F. Davis et autres

The COVID-19 pandemic has disproportionately affected workers in certain industries and occupations, and the workplace can be a high-risk setting for SARS-CoV-2 transmission. In this study, we measured SARS-CoV-2 antibody prevalence and identified work-related risk factors in a population primarily working at …

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