Shanshan Shen

HSPA1A promotes immune-evasive colorectal liver metastasis through post-transcriptional stabilization of APP mRNA

Ying Wan, Zhifei Cao, Shanshan Shen, Ruidong Zuo et autres

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Antimicrobial Peptide BSN-37 Enhances Macrophage Immune Activation Through the circBptf–Rbm14-Mediated Regulatory Axis

Xiaojing Xia, Xujie Zhao, Yanhe Lv, Bingze Jiao et autres

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Analysis of HIV Antibody Testing Results in Huaian District, Huaian City from 2019 to 2023

Shanshan Shen

Purpose: To analyze the HIV antibody confirmation test results of our center from January 2019 to October 2023. There are a total of 33,836 cases of data. Based on the analyzed results and data, provide reliable data support and a scientific basis …

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Short- and long-term outcomes for early large esophageal carcinoma patients treated via double- and single-tunnel super minimally invasive surgery: a multicentre, retrospective cohort study

Qianqian Chen, Shuai Tian, Shanshan Shen, Yu Bao et autres

Background and study aim Super minimally invasive surgery (SMIS) via endoscopic submucosal tunnel dissection (ESTD) has shown promising preliminary efficacy for the treatment of large early esophageal cancer (EEC). This study reports the short- and long-term outcomes of both single- and double-tunnel …

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Macrophage Extracellular Traps Modulate the Compensatory Anti-inflammatory Response Syndrome through IL-33/ST2 Signaling in Severe Acute Pancreatitis

Quan Zhou, Zhao Shi, Xuan Wang, Kun Liu et autres

Severe acute pancreatitis (SAP) is characterized by biphasic systemic inflammation, progressing from initial pro-inflammatory systemic inflammatory response syndrome (SIRS) to subsequent immunosuppressive compensatory anti-inflammatory response syndrome (CARS), which increases infection risks and predicts poor prognosis. Using a pancreatic duct ligation and caerulein-induced …

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Endoscopic ultrasound—guided duodenojejunostomy for a duodenal duplication cyst presenting with duodenal obstruction

Shuang Nie, Lei Wang, Shanshan Shen

Background and Aims: Duodenal duplications are rare congenital anomalies that can cause gastrointestinal obstruction. Although surgical resection is the standard treatment, endoscopic alternatives are increasingly being explored. Endoscopic ultrasound (EUS)-guided anastomosis techniques have shown promise in treating gastrointestinal obstructions. However, their application …

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TAF15 in tumor-associated macrophages enhances protumorigenic polarization and promotes cholangiocarcinoma progression

Yu Liu, Bing Xu, Tianming Zhao, Hong‐Wen Liu et autres

Background & Aims Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and aggressive cancer. Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), where they facilitate the malignant progression of ICC and reshape the TME. TATA-binding protein-associated factor 15 (TAF15), a protein …

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Secondary endoscopic ultrasound-guided gastroenterostomy to solve stent dysfunction and prolong lifetime in malignant gastric outlet obstruction

Xintong Zhang, Lei Wang, Shanshan Shen

Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is effective and safe to relieve gastric outlet obstruction (GOO) [ 1 ]. Long-term stent dysfunction, including stent occlusion, migration, and delamination, could be resolved by food disimpaction, stent exchanges, or an overlapping stent [ 2 ] [ …

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Survival and pathological response in pancreatic ductal adenocarcinoma after preoperative therapy with PD-1 blockade plus chemoradiotherapy followed by surgical resection

Elyar Abaydulla, Qi Li, Jialing Li, Defu Hu et autres

Background Neoadjuvant PD-1 blockade plus chemoradiotherapy has resulted in improved clinical response in pancreatic ductal adenocarcinoma (PDAC); however, the effects on pathological response (PR) and survival remain unknown. This study was to identify the survival and PR of patients with PDAC undergoing …

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Enhancing PD‐1 Inhibitor Efficacy in Cholangiocarcinoma by Reprogramming Tumor‐Associated Neutrophils With CAF‐Derived Extracellular Vesicles Loaded with Ruxolitinib

Qi Chen, Yue Zhou, Xudong Zhu, Lei Xu et autres

Abstract Tumor‐associated neutrophils (TANs), particularly the N2 phenotype, contribute to T cell exhaustion in cholangiocarcinoma (CCA), leading to low response rates to PD‐1 inhibitor therapy. To address this issue, cancer‐associated fibroblast (CAF)‐derived extracellular vesicles loaded with ruxolitinib (CEVs@Ru) are developed to selectively …

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A case of intraductal papillary neoplasm of the bile duct arising in Lynch syndrome resected under an endoscope

Shanshan Shen, Shuang Nie, Lei Wang

A 65-year-old female found a hilar bile duct mass with associated biliary dilation under CT and MRI during routine surveillance. Notably, the patient had a complex medical history, receiving segmental liver resection 8 years ago for intraductal papillary neoplasm of the bile …

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Endoscopic management of a nasobiliary drain migrated into the gallbladder

Jiaqi Shi, Shuang Nie, Shanshan Shen, Wen Li et autres

Background and Aims: Endoscopic gallbladder-preserving cholecystolithotomy is a potential alternative to laparoscopic cholecystectomy for patients desiring gallbladder preservation and meeting biliary lithotripsy indications. This article reports a case of initial endoscopic failure requiring multiple interventions, highlighting the importance of individualized decision-making and …

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