Takuya Goto

ASO Visual Abstract: SPARC Expression Induces COL1A1/COL3A1 Representing Aggressive Molecular Cancer-Associated Fibroblast Signatures and CSF1-Mediated Cancer Invasion in Colorectal Cancer

Yusuke Nie, Yoshiki Fujiyama, Shumpei Shibaki, Riku Okamoto et autres

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SPARC Induces COL1A1/COL3A1 Expressions Representing Aggressive Molecular Cancer-Associated Fibroblasts Signatures and CSF1-Mediated Cancer Invasion in Colorectal Cancer

Yusuke Nie, Yoshiki Fujiyama, Shumpei Shibaki, Riku Okamoto et autres

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Impact of Ghrelin‐Depleting Gastrectomy on Long‐Term Endocrine and Metabolic Health With a Focus on Skeletal Muscle and Bone Mineral Content

Hiroki Harada, Takuya Goto, Keishi Yamashita, Hiroyuki Minoura et autres

ABSTRACT Background Advances in diagnostic and surgical techniques have improved survival rates for gastric cancer patients. However, gastrectomy involving ghrelin‐secreting regions of the upper gastric greater curvature can lead to long‐term endocrine and metabolic disturbances, including reductions in serum ghrelin and insulin‐like …

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Healthcare-associated infections in Japanese hospitals: results from a large-scale multicenter point-prevalence survey in Aichi, 2020

Hiroshi Morioka, Yusuke Koizumi, Keisuke Oka, Masami Okudaira et autres

Abstract Objective: Healthcare-associated infections (HAIs) pose significant challenges to healthcare systems worldwide. Epidemiological data are essential for effective HAI control; however, comprehensive information on HAIs in Japanese hospitals is limited. This study aimed to provide an overview of HAIs in Japanese hospitals. …

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Less demand on stem cell marker-positive cancer cells may characterize metastasis of colon cancer

Takeshi Kaida, Yoshiki Fujiyama, Takafumi Soeno, Mitsuo Yokota et autres

BACKGROUND: CD44 and CD133 are stem cell markers in colorectal cancer (CRC). CD44 has distinctive isoforms with different oncological properties like total CD44 (CD44T) and variant CD44 (CD44V). Clinical significance of such markers remains elusive. METHODS: Sixty colon cancer were examined for …

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Short‐ and long‐term outcomes of robotic‐assisted laparoscopic surgery for rectal cancer: A single‐center retrospective cohort study

Takahiro Yamanashi, Hirohisa Miura, Toshimichi Tanaka, Akiko Watanabe et autres

INTRODUCTION: Whether rectal cancer surgery by robotic-assisted laparoscopic surgery provides beneficial advantages remains controversial. Although favorable outcomes in terms of the safety and technical feasibility of robotic-assisted laparoscopic surgery have been demonstrated for rectal cancer, long-term oncological outcomes for robotic-assisted laparoscopic surgery …

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Comparison of short‐term outcomes of robotic‐assisted and conventional laparoscopic surgery for rectal cancer: A propensity score‐matched analysis

Takahiro Yamanashi, Hirohisa Miura, Toshimichi Tanaka, Akiko Watanabe et autres

INTRODUCTION: The advantages of robotic-assisted laparoscopic surgery (RALS) for rectal cancer remain controversial. This study clarified and compared the short-term outcomes of RALS for rectal cancer with those of conventional laparoscopic surgery (CLS). METHODS: The records of 303 consecutive patients who underwent …

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Activated iNKT cells promote liver repair by acceleration of macrophage polarization

Yoshiya Ito, Takuya Goto, Masashi Satoh, Atsushi Yamashita et autres

Macrophage polarization is critical for liver tissue repair following acute liver injury. However, the underlying mechanisms of macrophage phenotype switching are not well defined. Invariant natural killer T (iNKT) cells orchestrate tissue inflammation and tissue repair by regulating cytokine production. Herein, we …

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