Hiroyuki Minoura

Appetite-preserving gastrectomy attenuates early postoperative deterioration of bone quality after surgery in esophagogastric junction cancer

Hiroki Harada, Hiroyuki Minoura, Kota Okuno, Kaori Kawana et autres

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Comparative Oncology: Cross-Sectional Single-Cell Transcriptomic Profiling of the Tumor Microenvironment Across Seven Human Cancers

Riku Okamoto, Kota Okuno, Akiko Watanabe, Kanako Naito et autres

Background/Objectives: To elucidate the differential transcriptional and intercellular signaling features of tumor components across various cancers, we conducted a comparative analysis using single-cell RNA sequencing (scRNA-seq). This technology enables detailed characterization of tumor ecosystems and may explain variations in tumor behavior among …

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Clinical utility impact of DNA-based cytology using droplet digital methylation-specific PCR in gastric cancer

Hiroki Harada, Takafumi Soeno, Akira Ooki, Kanako Naito et autres

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ASO Visual Abstract: Exploring the Role of CDO1 in Breast Cancer: Insights into Tumor Biology and Therapeutic Potential

Shiori Fujino, Keishi Yamashita, Riku Okamoto, Shumpei Shibaki et autres

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Exploring the Role of CDO1 in Breast Cancer: Insights into Tumor Biology and Therapeutic Potential

Shiori Fujino, Keishi Yamashita, Riku Okamoto, Shumpei Shibaki et autres

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Impact of Ghrelin‐Depleting Gastrectomy on Long‐Term Endocrine and Metabolic Health With a Focus on Skeletal Muscle and Bone Mineral Content

Hiroki Harada, Takuya Goto, Keishi Yamashita, Hiroyuki Minoura et autres

ABSTRACT Background Advances in diagnostic and surgical techniques have improved survival rates for gastric cancer patients. However, gastrectomy involving ghrelin‐secreting regions of the upper gastric greater curvature can lead to long‐term endocrine and metabolic disturbances, including reductions in serum ghrelin and insulin‐like …

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Appetite-preserving gastrectomy (APG) for esophagogastric junction cancer: preserving the residual stomach as an endocrine organ

Naoki Hiki, Tadashi Higuchi, Koshi Kumagai, Kota Okuno et autres

BACKGROUND: Loss of appetite following gastric cancer surgery, particularly total gastrectomy, significantly impacts patient quality of life due to the removal of the ghrelin-secreting region. We developed appetite-preserving gastrectomy (APG), a modified total gastrectomy that preserves this region. METHODS: Ten consecutive patients …

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Cancer-Associated Fibroblasts Genes and Transforming Growth Factor Beta Pathway in Gastric Cancer for Novel Therapeutic Strategy

Hiroyuki Minoura, Riku Okamoto, Naoki Hiki, Keishi Yamashita

Background-Objective: Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment of gastric cancer (GC). Understanding the molecular characteristics of CAFs-associated genes (CAFGs) is essential for elucidating their role in tumor progression and prognosis. This review aims to summarize the current …

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Esophago-jejunal anastomosis with open approach using the parachute technique to prioritize safety after resection of esophagogastric junction cancer

Tadashi Higuchi, Masahiro Niihara, Hiroyuki Minoura, Hiroki Harada et autres

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Esophago-jejunal anastomosis with open approach using the parachute technique to prioritize safety after resection of esophagogastric junction cancer

Tadashi Higuchi, Masahiro Niihara, Hiroyuki Minoura, Hiroki Harada et autres

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Conditions for improved accuracy of noninvasive preimplantation genetic testing for aneuploidy: Focusing on the zona pellucida and early blastocysts

Hiroki Takeuchi, Midori Morishita, M Uemura, Tadashi Maezawa et autres

Purpose: Recently, noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free deoxyribonucleic acid has been developed; however, there are few reports on this and the results are inconsistent. This study was conducted to optimize the cultural environment. Methods: We used 35 blastocysts …

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Pregnancy Rates after Hysteroscopic Endometrial Polypectomy versus Endometrial Curettage Polypectomy: A Retrospective Study

Mikiko Nishioka, Tadashi Maezawa, Hiroki Takeuchi, Katsuyuki Hagiwara et autres

Background and Objectives: A relationship between endometrial polypectomy and in vitro fertilization (IVF) pregnancy outcomes has been reported; however, only a few studies have compared polyp removal techniques and pregnancy rates. We investigated whether different polypectomy techniques with endometrial curettage and hysteroscopic …

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